The cognitive impact of light: illuminating ipRGC circuit mechanisms

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(3), P. 159 - 175

Published: Jan. 26, 2024

Language: Английский

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Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Alzheimer's disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms treatments remain elusive. Here we report therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model disease. Our findings reveal that treatment prevents memory decline 4-month-old mice motivation loss 14-month-old mice, accompanied restoration glial water channel aquaporin-4 polarity, improved brain drainage efficiency, reduction hippocampal lipid accumulation. We further demonstrate beneficial effects are mediated through activation vLGN/IGL-Re visual circuit. Notably, concomitant use anti-Aβ antibody with demonstrates soluble Aβ clearance performance mice. These offer functional evidence on Aβ-related pathologies suggest its as supplementary strategy to augment efficacy antibody-based therapy. Treatments for (AD) limited. Here, authors show activates circuit boost glymphatic drainage, enhances memory, motivation, therapy AD.

Language: Английский

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Mood variation under dual regulation of circadian clock and light

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: Jan. 22, 2025

The intricate relationship between circadian rhythms and mood is well-established. Disturbances in sleep often precede the development of disorders, such as major depressive disorder (MDD), bipolar (BD), seasonal affective (SAD). Two primary factors, intrinsic clocks light, drive natural fluctuations throughout day, mirroring patterns sleepiness wakefulness. Nearly all organisms possess that coordinate daily rhythms, with light serving environmental cue to synchronize these internal timekeepers 24-hour cycle. Additionally, directly influences states. Disruptions those caused by jet lag, shift work, or reduced daylight hours, can trigger exacerbate symptoms. complex subtle connections disruptions dysregulation suggest focusing solely on individual clock genes insufficient fully understand their etiology progression. Instead, instability may arise from systemic misalignments external cycles synchronization clocks. Here, we synthesize past research independent contributions regulation, drawing particularly insights animal studies illuminate fundamental mechanisms relevant human health.

Language: Английский

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Circadian-independent light regulation of mammalian metabolism

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(6), P. 1000 - 1007

Published: June 3, 2024

Language: Английский

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Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 29, 2024

Abstract While light can affect emotional and cognitive processes of the medial prefrontal cortex (mPFC), no light-encoding was hitherto identified in this region. Here, extracellular recordings awake mice revealed that over half studied mPFC neurons showed photosensitivity, diminished by inhibition intrinsically photosensitive retinal ganglion cells (ipRGCs), or upstream thalamic perihabenular nucleus (PHb). In 15% neurons, firing rate changed monotonically along light-intensity steps gradients. These light-intensity-encoding comprised four types, two enhancing suppressing their with increased intensity. Similar types were PHb, where they exhibited shorter latency sensitivity. Light suppressed prelimbic activity but boosted infralimbic activity, mirroring regions’ contrasting roles fear-conditioning, drug-seeking, anxiety. We posit photosensitivity represents a substrate light-susceptible, mPFC-mediated functions, which could be ultimately as therapeutical target psychiatric addiction disorders.

Language: Английский

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Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expression

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 18, 2025

Mitochondria absorb short wavelengths around 420 nm. This is associated with reduced ATP and restricted mobility. The 420–450 nm range a significant element of LED lighting computer monitors. Here we expose freely moving mice to show rapidly weight gain within week. may be due mitochondrial demand for circulating carbohydrates. Both groups displayed marked shifts in serum cytokines. Open field mobility was examined. distance travelled similar between both experimental their controls. However, showed avoidance central regions consistent anxiety-like behaviours. the group whose wavelength exposure closer peak absorbance. These data demonstrate potential hazards specific visual now common built environment. Data are wider literature on systemic problems arising from light.

Language: Английский

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Lateral habenula astroglia modulate the potentiating antidepressant-like effects of bright light stimulation in intractable depression

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Beside image vision, light plays a pivotal role in regulating diverse non-visual functions, including affective behaviors. Recently, bright stimulation (BLS) was revealed to be beneficial for treating non-seasonal depression, although its mechanism of action is not fully understood. We developed novel mouse model refractory induced through social isolation and chronic despair during the active (dark) phase animal, we have tested if antidepressant treatments, BLS, could protect against anxio-depressive-like behavior. report that anxiety- depressive-like behaviors are resistant BLS as well both conventional new antidepressants, ketamine. Remarkably, unveil potentiates effect this mediated via rod retinal photoreceptors. Furthermore, demonstrate chemogenetic activation lateral habenula (LHb) astroglia serotonin (5-HT) depletion prevent potentiating on despair. These results reveal, first time, enhances efficacy antidepressants an unexpectedly circuit involving rods, LHb 5-HT.

Language: Английский

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U-shaped association between myeloperoxidase levels and anxiety risk: a cross-sectional study in a Chinese population

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 7, 2025

Objective This study investigates the association between myeloperoxidase (MPO) levels and anxiety risk in Chinese adults explores potential effect modifiers, with implications for neuroinflammatory biomarker-guided prevention strategies. Methods Using cross-sectional data from 30,418 undergoing routine health examinations (July 2020–June 2021), severity was assessed via Self-Rating Anxiety Scale (SAS; score ≥ 50 as clinically relevant). Plasma MPO quantified by ELISA. Multivariate logistic regression, restricted cubic splines (RCS), threshold analysis, subgroup interactions were conducted to evaluate nonlinear associations. Results A U-shaped relationship identified. In fully adjusted models, participants lowest (Q1: ≤29.77 ng/mL, OR = 1.15, 95% CI: 1.03–1.28, p 0.01) highest quintiles (Q5: ≥47.3 1.17, 1.05–1.31, 0.004) exhibited significantly elevated risks compared reference quintile (Q2: 29.8–34.7 ng/mL). RCS analysis confirmed a ( nonlinearity < 0.01), an inflection point at 30 ng/mL: below this threshold, each 1 ng/mL increase reduced (OR 0.982, 0.970–0.994), while above it heightened 1.004, 1.001–1.008). Diabetes mellitus modified -interaction 0.028), diabetic individuals showing amplified higher plasma (Q5 1.84 vs. non-diabetic Q5 1.15). Conclusion demonstrates independent of cardiometabolic confounders. Diabetic exhibit susceptibility MPO-related anxiety, suggesting synergistic pathways. Monitoring may aid stratification personalized interventions, particularly populations diabetes.

Language: Английский

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Effects of chronic light cycle disruption during adolescence on circadian clock, neuronal activity rhythms, and behavior in mice

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: June 17, 2024

The advent of artificial lighting, particularly during the evening and night, has significantly altered predictable daily light dark cycles in recent times. Altered environments disrupt biological clock negatively impact mood cognition. Although adolescents commonly experience chronic changes light/dark cycles, our understanding how adolescents’ brain adapts to remains limited. Here, we investigated cycle disruption (LCD) adolescence, exposing adolescent mice 19 h 5 darkness for days 12 L:12D 2 per week (LCD group) 4 weeks. We showed that LCD exposure did not affect circadian locomotor activity but impaired memory increased avoidance response mice. Clock gene expression neuronal rhythms analysis revealed disrupted local molecular dentate gyrus (DG) medial amygdala (MeA) pacemaker (SCN). In addition, characterized photoresponsiveness MeA somatostatin neurons are affected by acute aberrant adolescence. Our research provides new evidence highlighting potential consequences pubertal development on physiology behaviors.

Language: Английский

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Turn off that night light! Light-at-night as a stressor for adolescents

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 31, 2024

Light-at-night is known to produce a wide variety of behavioral outcomes including promoting anxiety, depression, hyperactivity, abnormal sociability, and learning memory deficits. Unfortunately, we all live in 24-h society where people are exposed light-at-night or light pollution through night-shift work - the need for all-hours emergency services as well building street-lights, making exposure practically unavoidable. Additionally, increase screentime (tvs smart devices) during night also contributes poorer sleep impairments. Compounding these factors fact that adolescents tend be "night owls" prefer an evening chronotype compared younger children adults, so teenagers will have higher likelihood being light-at-night. Making matters worse prevalence high-school start times 8 am earlier combination too early school times, night, preference chronotypes recipe reduced sleep, which can contribute increased susceptibility issues this population. As such, mini-review show, using both human rodent model studies, how affects stress responses, connecting photic signaling circadian timing system hypothalamic-pituitary adrenal axis. review demonstrate more likely exhibit behavior response due changes development hormone regulation time period, discuss potential interventions help mitigate negative effects.

Language: Английский

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