Chemical Engineering Journal, Год журнала: 2024, Номер 499, С. 155904 - 155904
Опубликована: Сен. 17, 2024
Язык: Английский
Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)
Опубликована: Май 30, 2024
Язык: Английский
Процитировано
79
Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(10), С. 849 - 868
Опубликована: Июль 18, 2024
Язык: Английский
Процитировано
71
Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(13), С. 1515 - 1522
Опубликована: Март 9, 2024
Comprehensive Summary We have compiled eight promising strategies for enhancing the specificity and selectivity of nanozymes, as depicted in comprehensive summary above. Enzymes exhibit intricate sophisticated structures, including substrate channels active sites, which can inform design nanozymes. Replication these structural features application facet engineering/doping techniques significantly enhance catalytic Alternatively, use Molecularly Imprinted Polymers (MIPs) to coat nanozymes represents an effective approach impart specificity. Furthermore, several straightforward stopgap been devised improve nanozyme analytical applications, such integration biorecognition elements sensor arrays through surface modification. image Key Scientists
Язык: Английский
Процитировано
37
Advanced Materials, Год журнала: 2024, Номер 36(33)
Опубликована: Июнь 14, 2024
Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.
Язык: Английский
Процитировано
18
Nature, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
The global spread of multidrug-resistant pathogenic fungi presents a serious threat to human health, necessitating the discovery antifungals with unique modes action1. However, conventional activity-based screening for previously undescribed antibiotics has been hampered by high-frequency rediscovery known compounds and lack new antifungal targets2. Here we report polyene antibiotic, mandimycin, using phylogeny-guided natural-product platform. Mandimycin is biosynthesized mand gene cluster, evolved in distinct manner from macrolide modified three deoxy sugars. It demonstrated potent broad-spectrum fungicidal activity against wide range fungal pathogens both vitro vivo settings. In contrast that target ergosterol, mandimycin mode action involves targeting various phospholipids cell membranes, resulting release essential ions cells. This ability bind multiple targets gives it robust as well capability evade resistance. identification strategy represents an important advancement uncovering antimicrobial action, which could be developed combat pathogens. Mandimycin, macrolide, exhibits strong possesses other this class.
Язык: Английский
Процитировано
5
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 28, 2025
Abstract Reducing L‐lactate levels in tumors is crucial for alleviating immunosuppression and enhancing treatment efficacy. Recently, bacteria have great potential improving lactate the tumor microenvironment due to their physiological properties, tropism, immunogenicity. However, developing bacterial‐based regulation platforms still facing challenges bacterial modification impacts on activity, macrophage phagocytosis, complex microenvironment. Herein, an engineered Lactobacillus acidophilus (LH@LA) developed, armed with a polymeric stealth coating that co‐loads oxidase (LOx) horseradish peroxidase (HRP). This protects from maintaining activity deep drug delivery. And then, LOx HRP can consume much site through enzyme cascade reaction improve immunosuppressive environment, while causing oxidative stress reduced ATP supply, thereby reversing AKT‐mTOR metabolic pathway activation inhibit growth. More interestingly, LA not only acts as natural enzyme's carrier, but also induces anti‐inflammatory M2 macrophages polarize into pro‐inflammatory M1 by secreting D‐lactate, antitumor immunotherapy. probiotic design provides new idea building safe efficient live delivery platform, providing reference cancer strategies clinical translation prospects.
Язык: Английский
Процитировано
3
Nano Letters, Год журнала: 2024, Номер 24(7), С. 2289 - 2298
Опубликована: Фев. 11, 2024
Antibiotic therapeutics to combat intestinal pathogen infections often exacerbate microbiota dysbiosis and impair mucosal barrier functions. Probiotics are promising strategies, because they inhibit colonization improve imbalance. Nevertheless, their limited targeting ability susceptibility oxidative stress have hindered therapeutic potential. To tackle these challenges, Ces3 is synthesized by in situ growth of CeO2 nanozymes with positive charges on probiotic spores, facilitating electrostatic interactions negatively charged pathogens possessing a high reactive oxygen species (ROS) scavenging activity. Importantly, can resist the harsh environment gastrointestinal tract. In mice S. Typhimurium-infected acute gastroenteritis, shows potent anti-S. Typhimurium activity, thereby alleviating dissemination into other organs. Additionally, owing its O2 deprivation capacity, promotes proliferation anaerobic probiotics, reshaping healthy microbiota. This work demonstrates promise combining antibacterial, anti-inflammatory, content regulation properties for gastroenteritis therapy.
Язык: Английский
Процитировано
13
Biomedical Journal, Год журнала: 2024, Номер 47(4), С. 100699 - 100699
Опубликована: Янв. 24, 2024
The development of nanotechnology has brought about groundbreaking advancements in diseases' diagnostics and therapeutics. Among them, multifunctional nanomaterials with enzyme-like activities (i.e., nanozymes) featured high stability, large surface area for bioconjugation, easy storage, offer unprecedented opportunities disease treatment. Recent years have witnessed the great progress nanozyme-based theranostics. To highlight these achievements, this review first introduces recent on nanozymes biosensing diagnostics. Then, it summarizes applications therapeutics including anti-tumor antibacterial treatment, anti-inflammatory other diseases In addition, several targeted strategies to improve therapeutic efficacy nanozyme are discussed. Finally, challenges field diagnosis therapy summarized.
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 301, С. 140431 - 140431
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
2
Fundamental Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1