Detecting
glutathione
S-transferases
(GSTs)
in
cardiovascular
diseases
is
crucial
for
understanding
oxidative
stress
and
its
role
disease
progression,
but
it
remains
challenging
due
to
GST's
dynamic
expression
interactions
with
other
cellular
components.
In
this
study,
the
CS-GST
optical
probe
was
developed
monitor
GST
activity.
The
demonstrated
unique
properties,
fluorescence
intensity
increasing
photoacoustic
signals
decreasing
upon
interacting
GST.
It
showed
excellent
sensitivity
selectivity,
strong
correlations
between
concentration.
vivo
experiments,
effectively
tracked
activity
foam
cell
models
mice,
showing
potential
as
a
biomarker
diseases.
Overall,
highly
sensitive,
selective,
stable
tool
promising
applications
research,
offering
noninvasive
method
real-time
monitoring
of
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(47)
Опубликована: Июль 31, 2024
Abstract
Near‐infrared
photosensitizers
are
valuable
tools
to
improve
treatment
depth
in
photodynamic
therapy
(PDT).
However,
their
low
singlet
oxygen
(
1
O
2
)
generation
ability,
indicated
by
quantum
yield,
presents
a
formidable
challenge
for
PDT.
To
overcome
this
challenge,
the
heptamethine
cyanine
was
decorated
with
biocompatible
S
Scy7
and
Se
Secy7
atom.
We
observe
that
exhibits
redshift
main
absorption
~840
nm
an
ultra‐efficient
capacity.
The
emergence
of
strong
intramolecular
charge
transfer
effect
between
atom
polymethine
chain
considerably
narrows
energy
gap
(0.51
eV),
heavy
strengthens
spin–orbit
coupling
(1.44
cm
−1
),
both
which
greatly
improved
high
triplet
state
yield
(61
%),
determines
.
Therefore,
demonstrated
excellent
capacity,
is
~24.5‐fold
indocyanine
green,
~8.2‐fold
IR780,
~1.3‐fold
methylene
blue
under
low‐power‐density
850
irradiation
(5
mW
−2
).
considerable
phototoxicity
toward
cancer
cells
buried
12
mm
tissue.
Nanoparticles
formed
encapsulating
within
amphiphilic
polymers
lecithin,
promising
antitumor
anti‐pulmonary
metastatic
effects,
exhibiting
remarkable
potential
advancing
PDT
deep
tissues.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101027 - 101027
Опубликована: Март 16, 2024
Multimodal
imaging,
which
combines
the
strengths
of
two
or
more
imaging
modalities
to
provide
complementary
anatomical
and
molecular
information,
has
emerged
as
a
robust
technology
for
enhancing
diagnostic
sensitivity
accuracy,
well
improving
treatment
monitoring.
Moreover,
application
multimodal
in
guiding
precision
tumor
can
prevent
under-
over-treatment,
thereby
maximizing
benefits
patients.
In
recent
years,
several
intriguing
magneto-optical
nanosystems
with
both
magnetic
optical
properties
have
been
developed,
leading
significant
breakthroughs
field
image-guided
therapy.
These
advancements
pave
way
precise
medicine.
This
review
summarizes
various
types
developed
recently
describes
their
applications
probes
agents
therapeutic
interventions.
Finally,
future
research
development
prospects
are
discussed
along
an
outlook
on
further
biomedical
field.
Frontiers in Cardiovascular Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Июль 12, 2024
The
research
progress
of
endoplasmic
reticulum
(ER)
stress
in
atherosclerosis
(AS)
is
great
concern.
ER,
a
critical
cellular
organelle,
plays
role
important
biological
processes
including
protein
synthesis,
folding,
and
modification.
Various
pathological
factors
may
cause
ER
stress,
sustained
or
excessive
triggers
the
unfolded
response,
ultimately
resulting
apoptosis
disease.
Recently,
researchers
have
discovered
importance
onset
advancement
AS.
contributes
to
occurrence
AS
through
different
pathways
such
as
apoptosis,
inflammatory
oxidative
autophagy.
Therefore,
this
review
focuses
on
mechanisms
development
related
therapeutic
targets,
which
will
contribute
deeper
understanding
disease's
pathogenesis
provide
novel
strategies
for
preventing
treating
Nano Letters,
Год журнала:
2024,
Номер
24(22), С. 6743 - 6752
Опубликована: Май 24, 2024
Lipid
nanoparticles
(LNPs)
represent
the
forefront
of
mRNA
delivery
platforms,
yet
achieving
precise
to
specific
cells
remains
a
challenge.
The
current
targeting
strategies
complicate
formulation
and
impede
regulatory
approval
process.
Here,
through
straightforward
regulation
helper
lipids
within
LNPs,
we
introduce
an
engineered
LNP
designed
for
targeted
into
hepatocytes
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
treatment.
optimized
LNP,
supplied
with
POPC
as
lipid,
exhibits
2.49-fold
increase
in
transfection
efficiency
compared
that
FDA-approved
LNPs.
CTP:phosphocholine
cytidylyltransferase
α
is
selected
system
self-calibration
phosphatidylcholine
levels
prevent
lipid
droplet
expansion
MAFLD.
This
strategy
effectively
regulates
homeostasis,
while
demonstrating
proven
biosafety.
Our
results
present
therapy
MAFLD
open
new
avenue
discovering
potent
enabling
cells.
ACS Sensors,
Год журнала:
2024,
Номер
9(2), С. 962 - 970
Опубликована: Янв. 31, 2024
In
this
work,
a
photoacoustic
(PA)
probe,
HDS-GGT,
was
developed
for
the
in
vivo
imaging
of
cardiovascular
diseases
by
monitoring
γ-glutamyl
transferase
(GGT)
dynamics.
HDS-GGT
exhibited
stable
PA
signal
with
auxiliary
absorbance
and
NIRF
variation
after
trigger
GGT.
all
three
modalities
absorbance,
NIRF,
PA,
could
quantitatively
reflect
GGT
level.
modality,
indicated
practical
advantages
including
high
sensitivity,
stability,
specificity.
living
oxidized
low-density
lipoprotein-induced
RAW264.7
cells,
proper
capability
plaques
visualizing
Moreover,
during
model
mice,
achieved
to
distinguish
from
healthy
blood
vessels
via
multiview
presentation.
also
suggest
severity
extracted
aorta
which
consistent
histological
staining
results.
The
information
herein
might
be
useful
future
investigations
on
diseases.
