Advanced Materials Technologies,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Abstract
Nasopharyngeal
cancer
(NPC)
is
a
challenging
malignancy
with
poor
prognosis
due
to
late
diagnosis
and
resistance
conventional
treatments.
Nanotechnology
offers
promising
solutions
address
these
limitations
by
enabling
targeted
drug
delivery,
enhancing
therapeutic
efficacy,
facilitating
multimodal
treatment
strategies.
By
leveraging
the
unique
properties
of
nanomaterials
nanocarrier
systems,
innovative
approaches
for
early
detection,
treatment,
therapy
can
be
developed,
paving
way
more
effective
personalized
management
NPC.
This
review
provides
comprehensive
overview
recent
developments
applications
nanotechnology
in
NPC
therapy,
focusing
on
improving
stability,
biodistribution,
delivery
tumors.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 21, 2025
In
this
study,
a
novel
cascade
nano
delivery
system,
Cur/Gox@LCOF,
was
developed
for
enhanced
breast
cancer
therapy.
The
system
loads
curcumin
(Cur)
and
glucose
oxidase
(Gox)
into
lipid
copper-based
organic
framework
(LCOF)
carrier
tumor
nanoparticles
were
characterized
by
X-ray
diffraction
(XRD),
transmission
electron
microscopy
(TEM),
dynamic
light
scattering
(DLS),
which
showed
that
they
had
uniform
spherical
morphology
with
an
average
particle
size
of
about
80
nm,
displaying
stable
colloidal
properties.
excellent
stability
under
simulated
physiological
conditions
exhibited
pH-responsive
drug
release
properties,
contributing
to
the
controlled
Cur
Gox.
results
in
vitro
cellular
experiments
Cur/Gox@LCOF
significantly
production
reactive
oxygen
species
(ROS),
leading
significant
cytotoxicity
cells.
addition,
also
demonstrated
therapeutic
efficacy
good
biocompatibility
mouse
model.
Thus,
study
nanocarrier
platform
triple
synergistic
chemokinetic/chemotherapy/starvation
therapy,
has
promising
applications
efficient
treatment
tumors.
Bionano
robots
have
been
recognized
as
a
tumor-selective
and
effective
platform
for
therapeutic
outcomes
they
synergize
the
merits
of
living
organisms
nanoparticles.
Here,
we
construct
self-mineralized
system
(denoted
SO@FeS)
by
employing
facultative
anaerobic
bacterium
Shewanella
oneidensis
MR-1
to
biosynthesize
FeS
NPs
cancer
therapy
with
dual
cell
death
pathways.
Biogenic
are
embedded
into
surface
inherent
photothermal
conversion
ability
low
crystallinity
tend
simultaneously
release
Fe2+
hydrogen
sulfide
(H2S)
in
an
acidic
environment.
As
result,
obtained
SO@FeS
hybrid
can
couple
versatility
nanoparticles
respiration
tumor-targeting
capacities
bacterium,
ultimately
leading
collaborative
clearance
tumor
cells.
Specifically,
cryo-soft
X-ray
tomography
(cryo-SXT)
is
near-native
3D
imaging
modality
that
directly
displays
trafficking
pathway
More
importantly,
cryo-SXT
captures
maps
SO@FeS-initiated
ferroptosis
apoptosis,
evidenced
remodeling
cytoplasmic
organelles.
This
work
offers
valuable
theoretical
insights
from
perspective
organelle
morphology,
links
subcellular
reorganization
pathways,
facilitates
design
nanoplatforms
integrate
multiple
therapies.
The
design
of
nanozymes
with
controlled
properties
and
well-defined
mechanisms
holds
significant
promise
for
advancing
next-generation
functional
biomaterials
tumor
theranostics.
Here,
we
develop
a
metal-organic
framework
(MOF)-derived
bimetallic
sulfide
nanozyme,
FCS,
ferrotherapy
via
combined
photothermal
catalytic
therapies.
FCS
is
synthesized
by
vulcanizing
the
zeolitic
imidazolate
framework-67
(ZIF-67)
into
cobalt
(Co3S4,
CS),
followed
ferrous
cation
exchange,
resulting
in
enhanced
near-infrared
II
conversion
superior
Fenton-like
activity.
Theoretical
calculations
attribute
these
enhancements
to
Fe
doping,
which
narrows
band
gap,
promotes
electron
transfer
H2O2,
lowers
energy
barrier
active
oxygen
species
generation.
effectively
induces
ferroptosis
through
lipid
peroxidation,
while
supporting
T2-weighted
magnetic
resonance
imaging.
This
study
presents
robust
strategy
MOF
transformation
multifunctional
theranostic
agents,
highlighting
role
metal
ion
doping
optimizing
nanozyme
performance.
Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
Ferroptosis,
as
novel
type
of
regulated
cell
death
that
has
garnered
widespread
attention
over
the
past
decade,
witnessed
continuous
discovery
an
increasing
number
regulatory
mechanisms.
Trace
metal
elements
play
a
multifaceted
and
crucial
role
in
oncology.
Interestingly,
it
been
increasingly
evident
these
elements,
such
copper,
are
involved
regulation
iron
accumulation,
lipid
peroxidation
antiferroptotic
systems,
suggesting
existence
“nonferrous”
mechanisms
ferroptosis.
In
this
review,
comprehensive
overview
composition
mechanism
ferroptosis
is
provided.
The
interaction
between
copper
metabolism
(including
cuproptosis)
cancer,
well
roles
other
trace
(such
zinc,
manganese,
cobalt,
molybdenum)
specifically
focused.
Furthermore,
applications
nanomaterials
based
on
metals
cancer
therapy
also
reviewed
potential
strategies
for
co‐targeting
cuproptosis
explored.
Nevertheless,
light
intricate
ambiguous
nature
interactions,
ongoing
research
essential
to
further
elucidate
ferroptosis,
thereby
facilitating
development
therapeutic
targets
approaches
treatment.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Abstract
The
risk
of
disease
highlights
the
necessity
point‐of‐care
testing.
Here,
a
ternary
hybrid
(MAP)
combining
metal–organic
frameworks
(MOFs),
aggregate‐induced
emission
luminogens,
and
Pt
nanoparticles
is
introduced.
MAP
demonstrates
greater
fluorescence
quantum
yield
(62.1%)
anti‐photobleaching
ability
than
conventional
fluorescent
MOFs
organic
fluorophores,
as
well
2214‐fold
16‐fold
increase
in
catalytic
capacity
over
those
horseradish
peroxidase
nanoparticles,
respectively.
exhibited
slight
attenuation
after
180
days
at
room
temperature
signal
intensity.
Polydopamine‐coated
polystyrene
microsphere‐enabled
microchips
are
economical,
user‐friendly,
portable.
combination
allows
for
determination
using
fluorescence/colorimetric
mode
different
scenarios.
Compared
with
enzyme‐linked
immunosorbent
assay,
41.9‐fold
sensitivity,
94.2%
decrease
time,
an
80.7%
cost.
accuracy
clinical
samples
reached
100%,
specificity
96.2%.
Chloramphenicol
enrofloxacin
serve
small
molecule
targets,
demonstrating
versatility
this
strategy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 19, 2024
Abstract
The
fabrication
of
synergistic
multifunctional
anti‐tumor
nanoplatforms
is
challenging
due
to
the
urgent
requirement
activate
different
therapeutic
modalities.
Although
multi‐modal
treatments
can
be
achieved
by
carrying
out
activation
with
exogenous
and
endogenous
stimulations
in
sequence,
this
tedious
manner
not
applicable
ideal
cancer
treatment.
Herein,
a
simple
heterojunction
Cu
2
O/Cu
2‐x
S
modified
gambogic
acid
hyaluronic
(CCS@GA@HA)
ingeniously
fabricated
for
treatment
combining
photothermal
therapy
(PTT),
photocatalytic
(PCT),
chemodynamic
(CDT)
potential
ferroptosis
just
activated
single
near
infrared
(NIR)
light
irradiation.
heterostructure
(CCS)
promoted
separation
transfer
efficiency
photogenerated
charge
carriers
exhibits
excellent
performance.
intervention
(GA)
downregulates
overexpression
heat
shock
protein
90
(HSP90),
which
make
it
possible
execute
mild
PTT.
And
CDT
performance
efficiently
improved
generated
from
Specifically,
CCS
appears
accelerate
accumulation
lipid
peroxides
(LPO)
inactivate
glutathione
peroxidase
4
(GPX4)
that
directly
induce
ferroptosis.
In
brief,
CCS@GA@HA
prominent
NIR‐triggered
effect
involving
PCT,
PTT,
enhanced
an
effective
tumor
Biomarker Research,
Год журнала:
2024,
Номер
12(1)
Опубликована: Окт. 31, 2024
Copper
is
an
important
trace
element
for
maintaining
key
biological
functions
such
as
cellular
respiration,
nerve
conduction,
and
antioxidant
defense.
Maintaining
copper
homeostasis
critical
human
health,
its
imbalance
has
been
linked
to
various
diseases,
especially
cancer.
Cuproptosis,
a
novel
mechanism
of
copper-induced
cell
death,
provides
new
therapeutic
opportunities
metal
ion
regulation
interact
with
fate.
This
review
insights
into
the
complex
mechanisms
metabolism,
molecular
basis
cuproptosis,
association
cancer
development.
We
assess
role
cuproptosis-related
genes
(CRGs)
associated
tumorigenesis,
their
importance
prognostic
indicators
targets,
impact
on
tumor
microenvironment
(TME)
immune
response.
Ultimately,
this
highlights
interplay
between
copper,
immunotherapy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
The
other
functions
of
bacterial
membrane
vesicles
(BMVs)
except
serving
as
immune
adjuvants
and
vaccine
platforms
are
yet
to
be
further
explored.
This
study
investigates
the
photothermal
properties
Rhodobacter
sphaeroides‐derived
BMVs
(RMVs)
beyond
their
immunostimulatory
properties.
A
multifunctional
nano‐biohybrid,
termed
CuM@RR,
is
constructed
by
encapsulating
Cu‐based
metal–organic
framework
(CuM)
nanoparticles
into
DSPE‐PEG
2000
‐RGD‐functionalized
RMVs,
leveraging
functionalization
cargo
capacity
BMVs.
‐RGD
modification
facilitates
targeted
delivery
CuM@RR
tumor
sites.
CuM
core
within
decomposes
in
acid
microenvironment,
releasing
Cu
2+
inducing
cell
cuproptosis.
Under
808
nm
near‐infrared
irradiation,
effect‐induced
apoptosis
synergizes
with
copper
ions
overload‐induced
cuproptosis,
causing
irreversible
mitochondrial
damage
cells
triggering
strong
immunogenic
death
(ICD).
released
damage‐associated
molecular
patterns
(DAMPs)
tumor‐associated
antigens
(TAAs)
during
ICD,
along
inherent
immunoadjuvant
elicit
robust
anti‐tumor
responses.
In
vivo
experiments
confirm
that
significantly
suppresses
growth
prevents
rechallenge
without
obvious
systemic
toxicity
under
synergistic
effects
therapy,
immunotherapy,
suggesting
great
potential
this
nano‐biohybrid
developing
safe
effective
multi‐therapeutic
strategies.
