Science,
Год журнала:
2015,
Номер
350(6265), С. 1199 - 1204
Опубликована: Дек. 3, 2015
Research
into
stem
cells
and
aging
aims
to
understand
how
maintain
tissue
health,
what
mechanisms
ultimately
lead
decline
in
cell
function
with
age,
the
regenerative
capacity
of
somatic
can
be
enhanced
promote
healthy
aging.
Here,
we
explore
effects
on
different
tissues.
Recent
research
has
focused
ways
that
genetic
mutations,
epigenetic
changes,
extrinsic
environmental
milieu
influence
functionality
over
time.
We
describe
each
these
three
factors,
which
they
interact,
interactions
decrease
health
are
optimistic
a
better
understanding
changes
will
uncover
potential
strategies
enhance
increase
resiliency
old
age.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2016,
Номер
8(5), С. a021873 - a021873
Опубликована: Май 1, 2016
The
transforming
growth
factor-β
(TGF-β)
is
the
prototype
of
TGF-β
family
and
differentiation
factors,
which
encoded
by
33
genes
in
mammals
comprises
homo-
heterodimers.
This
review
introduces
reader
to
with
its
complexity
names
biological
activities.
It
also
as
best-studied
factor
among
proteins,
diversity
roles
control
cell
proliferation
differentiation,
wound
healing
immune
system,
key
pathology,
for
example,
skeletal
diseases,
fibrosis,
cancer.
Science,
Год журнала:
2014,
Номер
344(6184), С. 630 - 634
Опубликована: Май 6, 2014
In
the
adult
central
nervous
system,
vasculature
of
neurogenic
niche
regulates
neural
stem
cell
behavior
by
providing
circulating
and
secreted
factors.
Age-related
decline
neurogenesis
cognitive
function
is
associated
with
reduced
blood
flow
decreased
numbers
cells.
Therefore,
restoring
functionality
should
counteract
some
negative
effects
aging.
We
show
that
factors
found
in
young
induce
vascular
remodeling,
culminating
increased
improved
olfactory
discrimination
aging
mice.
Further,
we
GDF11
alone
can
improve
cerebral
enhance
neurogenesis.
The
identification
slow
age-dependent
deterioration
mice
may
constitute
basis
for
new
methods
treating
age-related
neurodegenerative
neurovascular
diseases.
Cell Transplantation,
Год журнала:
2015,
Номер
24(3), С. 339 - 347
Опубликована: Март 1, 2015
The
human
umbilical
cord
is
a
promising
source
of
mesenchymal
stem
cells
(HUCMSCs).
Unlike
bone
marrow
cells,
HUCMSCs
have
painless
collection
procedure
and
faster
self-renewal
properties.
Different
derivation
protocols
may
provide
different
amounts
populations
cells.
Stem
cell
also
been
reported
in
other
compartments
the
cord,
such
as
lining,
perivascular
tissue,
Wharton's
jelly.
are
noncontroversial
sources
compared
to
embryonic
They
can
differentiate
into
three
germ
layers
that
promote
tissue
repair
modulate
immune
responses
anticancer
Thus,
they
attractive
autologous
or
allogenic
agents
for
treatment
malignant
nonmalignant
solid
soft
cancers.
HUCMCs
be
feeder
layer
pluripotent
Regarding
their
therapeutic
value,
storage
banking
system
should
established
immediately.
This
review
critically
evaluates
challenges,
future
directions
clinical
applications.
Frontiers in Physiology,
Год журнала:
2017,
Номер
8
Опубликована: Дек. 12, 2017
Many
physiological
changes
occur
with
ageing.
These
often,
directly
or
indirectly,
result
in
a
deterioration
of
the
quality
life
and
even
shortening
expectancy.
Besides
increased
levels
reactive
oxygen
species,
DNA
damage
cell
apoptosis,
another
important
factor
affecting
ageing
process
involves
systemic
chronic
low-grade
inflammation.
This
condition
has
already
been
shown
to
be
interrelated
several
(sub)clinical
conditions,
such
as
insulin
resistance,
atherosclerosis
Alzheimer's
disease.
Recent
evidence,
however,
shows
that
inflammation
also
contributes
loss
muscle
mass,
strength
functionality,
referred
sarcopenia,
it
affects
both
protein
breakdown
synthesis
through
signaling
pathways.
Classic
interventions
counteract
age-related
wasting
mainly
focus
on
resistance
training
and/or
supplementation
overcome
anabolic
inflexibility
from
which
elderly
suffer.
Although
benefit
these
classic
interventions,
therapeutic
potential
anti-inflammatory
strategies
is
great
interest,
might
add
up
to/support
effect
exercise
supplementation.
In
this
review,
molecular
interaction
between
inflammation,
sensitivity
metabolism
sarcopenic
will
addressed.
