Progress in Lipid Research,
Год журнала:
2023,
Номер
91, С. 101235 - 101235
Опубликована: Май 15, 2023
Lipids
play
important
roles
in
energy
metabolism
along
with
diverse
aspects
of
biological
membrane
structure,
signaling
and
other
functions.
Perturbations
lipid
are
responsible
for
the
development
various
pathologies
comprising
metabolic
syndrome,
obesity,
type
2
diabetes.
Accumulating
evidence
suggests
that
circadian
oscillators,
operative
most
cells
our
body,
coordinate
temporal
homeostasis.
In
this
review
we
summarize
current
knowledge
on
regulation
digestion,
absorption,
transportation,
biosynthesis,
catabolism,
storage.
Specifically,
focus
molecular
interactions
between
functional
clockwork
biosynthetic
pathways
major
classes
cholesterol,
fatty
acids,
triacylglycerols,
glycerophospholipids,
glycosphingolipids,
sphingomyelins.
A
growing
body
epidemiological
studies
associate
a
socially
imposed
misalignment
common
modern
society
incidence
disorders,
however
disruption
rhythms
connection
has
only
been
recently
revealed.
Here,
highlight
recent
unravel
mechanistic
link
intracellular
clocks,
homeostasis
diseases
based
animal
models
clock
innovative
translational
humans.
We
also
discuss
perspectives
manipulating
oscillators
as
potentially
powerful
approach
preventing
managing
disorders
human
patients.
Journal of Molecular Endocrinology,
Год журнала:
2019,
Номер
63(4), С. R93 - R102
Опубликована: Сен. 26, 2019
The
mammalian
circadian
clock
has
evolved
as
an
adaptation
to
the
24-h
light/darkness
cycle
on
earth.
Maintaining
cellular
activities
in
synchrony
with
of
organism
(such
eating
and
sleeping)
helps
different
tissue
organ
systems
coordinate
optimize
their
performance.
full
extent
mechanisms
by
which
cells
maintain
are
still
under
investigation,
but
involve
a
core
set
genes
that
regulate
large
networks
gene
transcription
both
direct
transcriptional
activation/repression
well
recruitment
proteins
modify
chromatin
states
more
broadly.
Annual Review of Nutrition,
Год журнала:
2019,
Номер
39(1), С. 291 - 315
Опубликована: Июнь 10, 2019
Molecular
clocks
are
present
in
almost
every
cell
to
anticipate
daily
recurring
and
predictable
changes,
such
as
rhythmic
nutrient
availability,
adapt
cellular
functions
accordingly.
At
the
same
time,
nutrient-sensing
pathways
can
respond
acute
imbalance
modulate
orient
metabolism
so
cells
optimally
a
declining
or
increasing
availability
of
nutrients.
Organismal
circadian
rhythms
coordinated
by
behavioral
activity-rest
feeding-fasting
cycles
temporally
orchestrate
sequence
physiological
processes
optimize
metabolism.
Basic
research
has
largely
focused
on
functioning
self-sustaining
molecular
oscillator,
while
nutrition
science
yielded
insights
into
responses
caloric
deprivation
specific
macronutrients.
Integration
these
two
fields
actionable
new
concepts
timing
food
intake
led
emerging
practice
time-restricted
eating.
In
this
paradigm,
is
restricted
consistent
window
8-12
h.
This
paradigm
pervasive
benefits
multiple
organ
systems.
Endocrine Reviews,
Год журнала:
2021,
Номер
43(2), С. 405 - 436
Опубликована: Сен. 22, 2021
Time-restricted
feeding
(TRF,
animal-based
studies)
and
time-restricted
eating
(TRE,
humans)
are
an
emerging
behavioral
intervention
approach
based
on
the
understanding
of
role
circadian
rhythms
in
physiology
metabolism.
In
this
approach,
all
calorie
intake
is
restricted
within
a
consistent
interval
less
than
12
hours
without
overtly
attempting
to
reduce
calories.
This
article
will
summarize
origin
TRF/TRE
starting
with
concept
chronic
rhythm
disruption
increasing
risk
for
metabolic
diseases.
Circadian
usually
perceived
as
sleep-wake
cycle
dependent
arising
from
central
nervous
system.
However,
recent
discovery
peripheral
organs
plasticity
these
response
changes
nutrition
availability
raised
possibility
that
adopting
daily
short
window
can
sustain
robust
rhythm.
Preclinical
animal
studies
have
demonstrated
proof
identified
potential
mechanisms
driving
TRF-related
benefits.
Pilot
human
reported
promising
results
reducing
obesity,
diabetes,
cardiovascular
Epidemiological
indicated
maintaining
long
overnight
fast,
which
similar
TRE,
significantly
risks
Despite
early
successes,
more
clinical
mechanistic
needed
implement
TRE
alone
or
adjuvant
lifestyle
prevention
management
Human Molecular Genetics,
Год журнала:
2017,
Номер
26(R2), С. R128 - R138
Опубликована: Июль 11, 2017
Circadian
rhythms
are
24-h
in
physiology
and
behaviour
generated
by
molecular
clocks,
which
serve
to
coordinate
internal
time
with
the
external
world.
The
circadian
system
is
a
master
regulator
of
nearly
all
its
disruption
has
major
consequences
on
health.
Sleep
rhythm
(SCRD)
ubiquitous
feature
today's
24/7
society,
studies
shift-workers
have
shown
that
SCRD
can
lead
not
only
cognitive
impairment,
but
also
metabolic
syndrome
psychiatric
illness
including
depression
(1,2).
Mouse
models
clock
mutants
recapitulate
these
deficits,
implicating
mechanistic
causal
links
between
disease
pathophysiology
(3-5).
Importantly,
treating
reverses
attenuates
adverse
health
states
animal
(6,7),
thus
establishing
as
novel
therapeutic
target.
Significantly,
clock-controlled
gene
mutations
recently
been
identified
Genome-Wide
Association
Studies
(GWAS)
aetiology
sleep,
mental
disorders.
This
review
will
focus
upon
genetics
sleep
