Lipid metabolism around the body clocks DOI Creative Commons

Volodymyr Petrenko,

Flore Sinturel, Howard Riezman

et al.

Progress in Lipid Research, Journal Year: 2023, Volume and Issue: 91, P. 101235 - 101235

Published: May 15, 2023

Lipids play important roles in energy metabolism along with diverse aspects of biological membrane structure, signaling and other functions. Perturbations lipid are responsible for the development various pathologies comprising metabolic syndrome, obesity, type 2 diabetes. Accumulating evidence suggests that circadian oscillators, operative most cells our body, coordinate temporal homeostasis. In this review we summarize current knowledge on regulation digestion, absorption, transportation, biosynthesis, catabolism, storage. Specifically, focus molecular interactions between functional clockwork biosynthetic pathways major classes cholesterol, fatty acids, triacylglycerols, glycerophospholipids, glycosphingolipids, sphingomyelins. A growing body epidemiological studies associate a socially imposed misalignment common modern society incidence disorders, however disruption rhythms connection has only been recently revealed. Here, highlight recent unravel mechanistic link intracellular clocks, homeostasis diseases based animal models clock innovative translational humans. We also discuss perspectives manipulating oscillators as potentially powerful approach preventing managing disorders human patients.

Language: Английский

Circadian clock genes and the transcriptional architecture of the clock mechanism DOI Open Access
Kimberly H. Cox, Joseph S. Takahashi

Journal of Molecular Endocrinology, Journal Year: 2019, Volume and Issue: 63(4), P. R93 - R102

Published: Sept. 26, 2019

The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with of organism (such eating and sleeping) helps different tissue organ systems coordinate optimize their performance. full extent mechanisms by which cells maintain are still under investigation, but involve a core set genes that regulate large networks gene transcription both direct transcriptional activation/repression well recruitment proteins modify chromatin states more broadly.

Language: Английский

Citations

360
Medicine in the Fourth Dimension DOI Creative Commons
Christopher R. Cederroth, Urs Albrecht, Joseph Bass

et al.

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(2), P. 238 - 250

Published: Aug. 1, 2019

Language: Английский

Citations

314
Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases DOI Open Access
Amandine Chaix, Emily N. C. Manoogian, Girish C. Melkani

et al.

Annual Review of Nutrition, Journal Year: 2019, Volume and Issue: 39(1), P. 291 - 315

Published: June 10, 2019

Molecular clocks are present in almost every cell to anticipate daily recurring and predictable changes, such as rhythmic nutrient availability, adapt cellular functions accordingly. At the same time, nutrient-sensing pathways can respond acute imbalance modulate orient metabolism so cells optimally a declining or increasing availability of nutrients. Organismal circadian rhythms coordinated by behavioral activity-rest feeding-fasting cycles temporally orchestrate sequence physiological processes optimize metabolism. Basic research has largely focused on functioning self-sustaining molecular oscillator, while nutrition science yielded insights into responses caloric deprivation specific macronutrients. Integration these two fields actionable new concepts timing food intake led emerging practice time-restricted eating. In this paradigm, is restricted consistent window 8-12 h. This paradigm pervasive benefits multiple organ systems.

Language: Английский

Citations

313
Circadian rhythm as a therapeutic target DOI
Wei Ruan, Xiaoyi Yuan, Holger K. Eltzschig

et al.

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(4), P. 287 - 307

Published: Feb. 15, 2021

Language: Английский

Citations

299
Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy DOI
Robert Dallmann, Alper Okyar,

Francis Lévi

et al.

Trends in Molecular Medicine, Journal Year: 2016, Volume and Issue: 22(5), P. 430 - 445

Published: April 5, 2016

Language: Английский

Citations

238
Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock DOI Open Access
Zhen Dong, Guoxin Zhang, Meng Qu

et al.

Cancer Discovery, Journal Year: 2019, Volume and Issue: 9(11), P. 1556 - 1573

Published: Aug. 27, 2019

Abstract Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSC). Here, we show that GSCs, differentiated (DGC), and nonmalignant brain cultures all displayed robust circadian rhythms, yet GSCs alone exquisite dependence on core clock transcription factors, BMAL1 CLOCK, for optimal cell growth. Downregulation of or CLOCK in induced cell-cycle arrest apoptosis. Chromatin immunoprecipitation revealed preferentially bound metabolic genes was associated with active chromatin regions compared neural cells. Targeting attenuated mitochondrial function reduced expression tricarboxylic acid cycle enzymes. Small-molecule agonists two independent BMAL1–CLOCK negative regulators, the cryptochromes REV-ERBs, downregulated factors GSC Combination cryptochrome REV-ERB synergistic antitumor efficacy. Collectively, these findings co-opt regulators beyond canonical circuitry to promote stemness maintenance metabolism, offering novel therapeutic paradigms. Significance: Cancer malignant tumor-cell populations. We demonstrate selectively depend increased binding promoting tumor metabolism. Supporting clinical relevance, pharmacologic targeting networks specifically disrupted cancer growth self-renewal. This article is highlighted In Issue feature, p. 1469

Language: Английский

Citations

237
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes DOI Creative Commons
Joan Camuñas-Soler,

Xiao-Qing Dai,

Yan Hang

et al.

Cell Metabolism, Journal Year: 2020, Volume and Issue: 31(5), P. 1017 - 1031.e4

Published: April 16, 2020

Language: Английский

Citations

237
Melatonin in type 2 diabetes mellitus and obesity DOI
Angeliki Karamitri, Ralf Jockers

Nature Reviews Endocrinology, Journal Year: 2018, Volume and Issue: 15(2), P. 105 - 125

Published: Dec. 7, 2018

Language: Английский

Citations

226
Time-restricted Eating for the Prevention and Management of Metabolic Diseases DOI Open Access
Emily N. C. Manoogian, Lisa S. Chow, Pam R. Taub

et al.

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 43(2), P. 405 - 436

Published: Sept. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Language: Английский

Citations

208
The genetics of circadian rhythms, sleep and health DOI Creative Commons
Aarti Jagannath, Lewis Taylor,

Zeinab Wakaf

et al.

Human Molecular Genetics, Journal Year: 2017, Volume and Issue: 26(R2), P. R128 - R138

Published: July 11, 2017

Circadian rhythms are 24-h in physiology and behaviour generated by molecular clocks, which serve to coordinate internal time with the external world. The circadian system is a master regulator of nearly all its disruption has major consequences on health. Sleep rhythm (SCRD) ubiquitous feature today's 24/7 society, studies shift-workers have shown that SCRD can lead not only cognitive impairment, but also metabolic syndrome psychiatric illness including depression (1,2). Mouse models clock mutants recapitulate these deficits, implicating mechanistic causal links between disease pathophysiology (3-5). Importantly, treating reverses attenuates adverse health states animal (6,7), thus establishing as novel therapeutic target. Significantly, clock-controlled gene mutations recently been identified Genome-Wide Association Studies (GWAS) aetiology sleep, mental disorders. This review will focus upon genetics sleep

Language: Английский

Citations

204