Lipid metabolism around the body clocks DOI Creative Commons

Volodymyr Petrenko,

Flore Sinturel, Howard Riezman

и другие.

Progress in Lipid Research, Год журнала: 2023, Номер 91, С. 101235 - 101235

Опубликована: Май 15, 2023

Lipids play important roles in energy metabolism along with diverse aspects of biological membrane structure, signaling and other functions. Perturbations lipid are responsible for the development various pathologies comprising metabolic syndrome, obesity, type 2 diabetes. Accumulating evidence suggests that circadian oscillators, operative most cells our body, coordinate temporal homeostasis. In this review we summarize current knowledge on regulation digestion, absorption, transportation, biosynthesis, catabolism, storage. Specifically, focus molecular interactions between functional clockwork biosynthetic pathways major classes cholesterol, fatty acids, triacylglycerols, glycerophospholipids, glycosphingolipids, sphingomyelins. A growing body epidemiological studies associate a socially imposed misalignment common modern society incidence disorders, however disruption rhythms connection has only been recently revealed. Here, highlight recent unravel mechanistic link intracellular clocks, homeostasis diseases based animal models clock innovative translational humans. We also discuss perspectives manipulating oscillators as potentially powerful approach preventing managing disorders human patients.

Язык: Английский

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes DOI Creative Commons
Dongyin Guan, Ying Xiong,

Patrícia Cristine Borck

и другие.

Cell, Год журнала: 2018, Номер 174(4), С. 831 - 842.e12

Опубликована: Июль 26, 2018

Overnutrition disrupts circadian metabolic rhythms by mechanisms that are not well understood. Here, we show diet-induced obesity (DIO) causes massive remodeling of enhancer activity in mouse liver, triggering synchronous high-amplitude both fatty acid (FA) synthesis and oxidation. SREBP expression was rhythmically induced DIO, leading to FA and, surprisingly, oxidation (FAO). DIO similarly caused a rhythm PPARα, which also required for FAO. Provision pharmacological activator PPARα abrogated the requirement FAO (but synthesis), suggesting indirectly controls via production endogenous ligands. The imparted time-of-day-dependent responsiveness lipid-lowering drugs. Thus, acquisition rhythmicity non-core clock components SREBP1 remodels gene transcription response overnutrition enables chronopharmacological approach disorders.

Язык: Английский

Процитировано

184
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging DOI Creative Commons
Daniel C. Levine,

Hee‐Kyung Hong,

Benjamin J. Weidemann

и другие.

Molecular Cell, Год журнала: 2020, Номер 78(5), С. 835 - 849.e7

Опубликована: Май 4, 2020

Язык: Английский

Процитировано

150
Circadian Entrainment Triggers Maturation of Human In Vitro Islets DOI Creative Commons
Juan R. Alvarez‐Dominguez,

Julie Donaghey,

Niloofar Rasouli

и другие.

Cell stem cell, Год журнала: 2019, Номер 26(1), С. 108 - 122.e10

Опубликована: Дек. 12, 2019

Язык: Английский

Процитировано

148
Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities DOI Creative Commons
Runyu Miao, Xinyi Fang, Yanjiao Zhang

и другие.

Cell Death and Disease, Год журнала: 2023, Номер 14(3)

Опубликована: Март 8, 2023

Abstract The maintenance of iron homeostasis is essential for proper endocrine function. A growing body evidence suggests that imbalance a key factor in the development several diseases. Nowadays, ferroptosis, an iron-dependent form regulated cell death, has become increasingly recognized as important process to mediate pathogenesis and progression type 2 diabetes mellitus (T2DM). It been shown ferroptosis pancreas β cells leads decreased insulin secretion; liver, fat, muscle induces resistance. Understanding mechanisms concerning regulation metabolism T2DM may lead improved disease management. In this review, we summarized connection between metabolic pathways molecular T2DM. Additionally, discuss potential targets treating analysis current limitations future directions these novel treatment targets.

Язык: Английский

Процитировано

90
Lipid metabolism around the body clocks DOI Creative Commons

Volodymyr Petrenko,

Flore Sinturel, Howard Riezman

и другие.

Progress in Lipid Research, Год журнала: 2023, Номер 91, С. 101235 - 101235

Опубликована: Май 15, 2023

Lipids play important roles in energy metabolism along with diverse aspects of biological membrane structure, signaling and other functions. Perturbations lipid are responsible for the development various pathologies comprising metabolic syndrome, obesity, type 2 diabetes. Accumulating evidence suggests that circadian oscillators, operative most cells our body, coordinate temporal homeostasis. In this review we summarize current knowledge on regulation digestion, absorption, transportation, biosynthesis, catabolism, storage. Specifically, focus molecular interactions between functional clockwork biosynthetic pathways major classes cholesterol, fatty acids, triacylglycerols, glycerophospholipids, glycosphingolipids, sphingomyelins. A growing body epidemiological studies associate a socially imposed misalignment common modern society incidence disorders, however disruption rhythms connection has only been recently revealed. Here, highlight recent unravel mechanistic link intracellular clocks, homeostasis diseases based animal models clock innovative translational humans. We also discuss perspectives manipulating oscillators as potentially powerful approach preventing managing disorders human patients.

Язык: Английский

Процитировано

58