Frontiers in Cellular Neuroscience,
Год журнала:
2020,
Номер
14
Опубликована: Апрель 15, 2020
Initially
developed
with
the
aim
of
generating
new
treatments
for
epilepsy,
gabapentin
and
pregabalin
("gabapentinoids")
were
engineered
to
mimic
action
GABA
modulate
metabolism.
Rather
than
their
intended
pharmacological
on
neurotransmission,
instead
they
exhibit
a
high
affinity
α2δ-1and
-2
subunits
voltage-activated
calcium
channels,
wherein
binding
gabapentinoids
inhibits
cellular
influx
attenuates
neurotransmission.
Despite
lack
activity
levels,
are
effective
at
suppressing
seizures
subsequently
approved
as
class
antiepileptic
therapy
partial-onset
epilepsy.
Through
same
hypothesized
molecular
mechanism
by
controlling
neuronal
hyperexcitability,
demonstrate
clear
efficacy
in
pain
management,
which
has
arguably
been
most
extensively
prescribed
application
date.
In
this
review,
we
focus
second-generation
gabapentinoid
widely
employed
treatment
variety
conditions.
We
also
discuss
wider
functional
roles
contributions
that
might
play
affecting
physiological
pathophysiological
processes.
Journal of Neuroscience,
Год журнала:
2020,
Номер
41(5), С. 855 - 865
Опубликована: Ноя. 25, 2020
Chronic
pain,
encompassing
conditions,
such
as
low
back
arthritis,
persistent
post-surgical
fibromyalgia,
and
neuropathic
pain
disorders,
is
highly
prevalent
but
remains
poorly
treated.
The
vast
majority
of
therapeutics
are
directed
solely
at
neurons,
despite
the
fact
that
signaling
between
immune
cells,
glia,
neurons
now
recognized
indispensable
for
initiation
maintenance
chronic
pain.
This
review
highlights
recent
advances
in
understanding
fundamental
neuroimmune
mechanisms
novel
therapeutic
targets
rodent
models
We
further
discuss
new
technological
developments
to
study,
diagnose,
quantify
contributions
patient
populations.
Pain,
Год журнала:
2018,
Номер
159(7), С. 1185 - 1197
Опубликована: Апрель 11, 2018
Abstract
Itch
and
pain
share
numerous
mechanistic
similarities.
Patients
with
chronic
itch
conditions
(for
instance
atopic
dermatitis
or
neuropathic
itch)
often
experience
symptoms
such
as
mechanical
alloknesis
hyperknesis.
These
dysesthesias
are
analogous
to
the
pain-associated
phenomena
allodynia
hyperalgesia,
which
observed,
for
example,
in
conditions.
Mechanical
represent
abnormal
sensory
states
(caused
by
neuroplastic
changes),
wherein
considerable
is
evoked,
light
cutaneous
stimuli
from
clothing
(alloknesis),
where
increased
perceived
response
normally
itch-evoking
(hyperknesis).
sensitization
have
been
explored
experimental
human
studies,
observed
patients,
animal
models
of
itch.
Limited
attention
has
paid
these
clinical
it
unknown
how
they
respond
antipruritics.
Psychophysical
quantitative
testing
can
quantify
presence,
severity,
spatial
extent
providing
a
proxy
measurement
sensitization.
This
review
outlines
current
assessment
techniques,
knowledge
on
mechanisms
hyperknesis,
presents
diverse
results
derived
studies
exploring
presence
patients.
A
key
role
neuronal
patients
accepted
used
assessments.
However,
precise
potential
implications
remain
be
evaluated.
The American Journal of Chinese Medicine,
Год журнала:
2020,
Номер
48(01), С. 1 - 16
Опубликована: Янв. 1, 2020
Pain
is
an
unpleasant
sensory
and
emotional
experience
in
many
diseases
often
caused
by
intense
or
damaging
stimuli.
negatively
affects
the
quality
of
life
increases
high
health
expenditures.
Drugs
with
analgesic
properties
are
commonly
used
to
relieve
pain,
but
these
Western
medications
could
be
overwhelmed
side
effects
including
tolerance
addiction.
Herbal
medicines
may
provide
alternative
measures
for
pain
management.
In
this
review
paper,
after
introduction
Chinese
medicine
theory
treatment
modality,
emphasis
placed
on
application
herbs
herbal
formulations
Three
most
herbs,
i.e.,
Corydalis
yanhusuo,
Ligusticum
chuanxiong,
Aconitum
carmichaeli,
reviewed.
Subsequently,
using
ancient
medical
remedy,
formulation
treating
common
conditions
associated
such
as
headache/migraine,
chest
abdominal
low
back
neuropathic
osteoarthritis,
cancer
presented.
considered
a
complementary
integrative
approach
modern
armamentarium
combating
pain.
Biology of Sex Differences,
Год журнала:
2021,
Номер
12(1)
Опубликована: Фев. 10, 2021
Sensory
perception
and
emotional
disorders
are
disproportionally
represented
in
men
women
thus
thought
to
be
modulated
by
different
sex
hormones
various
conditions.
Among
the
most
important
perceived
affect
sensory
processing
transduction
is
estrogen.
Numerous
previous
researchers
have
endeavored
demonstrate
that
estrogen
capable
of
modulating
activity
neurons
peripheral
central
sites
female,
male,
or
castrated
animals.
However,
underlying
mechanisms
its
modulation
neuronal
somewhat
unclear.
In
present
review,
we
discuss
possible
cellular
molecular
involved
nociception
Frontiers in Cellular Neuroscience,
Год журнала:
2020,
Номер
14
Опубликована: Апрель 15, 2020
Initially
developed
with
the
aim
of
generating
new
treatments
for
epilepsy,
gabapentin
and
pregabalin
("gabapentinoids")
were
engineered
to
mimic
action
GABA
modulate
metabolism.
Rather
than
their
intended
pharmacological
on
neurotransmission,
instead
they
exhibit
a
high
affinity
α2δ-1and
-2
subunits
voltage-activated
calcium
channels,
wherein
binding
gabapentinoids
inhibits
cellular
influx
attenuates
neurotransmission.
Despite
lack
activity
levels,
are
effective
at
suppressing
seizures
subsequently
approved
as
class
antiepileptic
therapy
partial-onset
epilepsy.
Through
same
hypothesized
molecular
mechanism
by
controlling
neuronal
hyperexcitability,
demonstrate
clear
efficacy
in
pain
management,
which
has
arguably
been
most
extensively
prescribed
application
date.
In
this
review,
we
focus
second-generation
gabapentinoid
widely
employed
treatment
variety
conditions.
We
also
discuss
wider
functional
roles
contributions
that
might
play
affecting
physiological
pathophysiological
processes.
