Nature,
Год журнала:
2022,
Номер
609(7926), С. 327 - 334
Опубликована: Авг. 24, 2022
Abstract
In
the
hippocampus,
spatial
maps
are
formed
by
place
cells
while
contextual
memories
thought
to
be
encoded
as
engrams
1–6
.
Engrams
typically
identified
expression
of
immediate
early
gene
Fos
,
but
little
is
known
about
neural
activity
patterns
that
drive,
and
shaped
by,
in
behaving
animals
7–10
Thus,
it
unclear
whether
Fos-expressing
hippocampal
neurons
also
encode
correlates
with
affects
specific
features
code
11
Here
we
measured
CA1
calcium
imaging
monitoring
induction
mice
performing
a
hippocampus-dependent
learning
task
virtual
reality.
We
find
high
form
ensembles
highly
correlated
activity,
exhibit
reliable
fields
evenly
tile
environment
have
more
stable
tuning
across
days
than
nearby
non-Fos-induced
cells.
Comparing
neighbouring
without
function
using
sparse
genetic
loss-of-function
approach,
disrupted
less
decreased
selectivity
lower
across-day
stability.
Our
results
demonstrate
Fos-induced
contribute
codes
encoding
accurate,
spatially
uniform
itself
has
causal
role
shaping
these
codes.
may
therefore
link
two
key
aspects
function:
for
underlie
cognitive
maps.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Май 20, 2021
Abstract
When
exploring
new
environments
animals
form
spatial
memories
that
are
updated
with
experience
and
retrieved
upon
re-exposure
to
the
same
environment.
The
hippocampus
is
thought
support
these
memory
processes,
but
how
this
achieved
by
different
subnetworks
such
as
CA1
CA3
remains
unclear.
To
understand
hippocampal
representations
emerge
evolve
during
familiarization,
we
performed
2-photon
calcium
imaging
in
mice
running
virtual
compared
trial-to-trial
dynamics
of
place
cells
over
days.
We
find
fields
rapidly
tend
shift
backwards
from
remap
environment
a
day
later.
In
contrast,
gradually
show
more
stable
day-to-day
dynamics.
These
results
reflect
roles
processing
familiarization
constrain
potential
mechanisms
them.
Cells
in
the
hippocampus
tuned
to
spatial
location
(place
cells)
typically
change
their
tuning
when
an
animal
changes
context,
a
phenomenon
known
as
remapping.
A
fundamental
challenge
understanding
remapping
is
fact
that
what
counts
‘‘context
change’’
has
never
been
precisely
defined.
Furthermore,
different
phenomena
have
classified
on
basis
of
how
much
after
types
and
degrees
context
change,
but
relationship
between
these
variables
not
clear.
We
address
ambiguities
by
formalizing
terms
hidden
state
inference.
According
this
view,
does
directly
reflect
objective,
observable
properties
environment,
rather
subjective
beliefs
about
environment.
show
framework
can
resolve
number
puzzles
nature
Nature,
Год журнала:
2022,
Номер
609(7926), С. 327 - 334
Опубликована: Авг. 24, 2022
Abstract
In
the
hippocampus,
spatial
maps
are
formed
by
place
cells
while
contextual
memories
thought
to
be
encoded
as
engrams
1–6
.
Engrams
typically
identified
expression
of
immediate
early
gene
Fos
,
but
little
is
known
about
neural
activity
patterns
that
drive,
and
shaped
by,
in
behaving
animals
7–10
Thus,
it
unclear
whether
Fos-expressing
hippocampal
neurons
also
encode
correlates
with
affects
specific
features
code
11
Here
we
measured
CA1
calcium
imaging
monitoring
induction
mice
performing
a
hippocampus-dependent
learning
task
virtual
reality.
We
find
high
form
ensembles
highly
correlated
activity,
exhibit
reliable
fields
evenly
tile
environment
have
more
stable
tuning
across
days
than
nearby
non-Fos-induced
cells.
Comparing
neighbouring
without
function
using
sparse
genetic
loss-of-function
approach,
disrupted
less
decreased
selectivity
lower
across-day
stability.
Our
results
demonstrate
Fos-induced
contribute
codes
encoding
accurate,
spatially
uniform
itself
has
causal
role
shaping
these
codes.
may
therefore
link
two
key
aspects
function:
for
underlie
cognitive
maps.
