Distinction of lymphoid and myeloid clonal hematopoiesis

Nature Medicine, Год журнала: 2021, Номер 27(11), С. 1921 - 1927

Опубликована: Окт. 18, 2021

Язык: Английский

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Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure

Circulation Research, Год журнала: 2020, Номер 128(2), С. 216 - 228

Опубликована: Ноя. 6, 2020

Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase 3a) is associated with increased incidence cardiovascular disease and poor prognosis patients chronic heart failure (HF) aortic stenosis. Although experimental studies suggest that clonal hematopoiesis-driver may enhance inflammation, specific signatures inflammatory cells in humans are missing.To define subsets immune mediating inflammation using single-cell RNA sequencing.Transcriptomic profiles peripheral blood mononuclear were analyzed n=6 HF harboring n=4 no sequencing. Monocytes carrying demonstrated a significantly expression genes compared monocytes derived from without mutations. Among the upregulated prototypic IL (interleukin) IL1B (interleukin 1B), IL6, IL8, inflammasome NLRP3, macrophage proteins CCL3 CCL4 as well resistin, which augments monocyte-endothelial adhesion. Silencing induced paracrine proinflammatory activation adhesion to endothelial cells. Furthermore, classical monocyte subset mutation carriers showed T-cell stimulating immunoglobulin superfamily members CD300LB, CD83, SIGLEC12, CD2 ligand cell molecule CD58, all be involved monocyte-T-cell interactions. further characterized alpha receptor constant chain changes T helper 1, 2, 17, CD8+ effector, CD4+ memory, regulatory T-cell-specific signatures.This study demonstrates circulating exhibit highly inflamed transcriptome, contribute aggravation HF.

Язык: Английский

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Biomarkers of aging

Science China Life Sciences, Год журнала: 2023, Номер 66(5), С. 893 - 1066

Опубликована: Апрель 11, 2023

Язык: Английский

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Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer

Cancer Cell, Год журнала: 2020, Номер 38(6), С. 818 - 828.e5

Опубликована: Окт. 23, 2020

Язык: Английский

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Acute myeloid leukaemia

The Lancet, Год журнала: 2023, Номер 401(10393), С. 2073 - 2086

Опубликована: Апрель 15, 2023

Язык: Английский

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Clonal expansion in non-cancer tissues

Nature reviews. Cancer, Год журнала: 2021, Номер 21(4), С. 239 - 256

Опубликована: Фев. 24, 2021

Язык: Английский

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Common and rare variant associations with clonal haematopoiesis phenotypes

Nature, Год журнала: 2022, Номер 612(7939), С. 301 - 309

Опубликована: Ноя. 30, 2022

Язык: Английский

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Inflammation-Induced Tumorigenesis and Metastasis

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(11), С. 5421 - 5421

Опубликована: Май 21, 2021

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms is now recognized as hallmark of cancer an attractive therapeutic target cancer. In this review, we discuss recent advances molecular how inflammation promotes suppresses anti-tumor immunity types solid tumors, including esophageal, gastric, colorectal, liver, pancreatic well hematopoietic malignancies.

Язык: Английский

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Circulating tumour cells for early detection of clinically relevant cancer

Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(7), С. 487 - 500

Опубликована: Июнь 2, 2023

Язык: Английский

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Embracing cancer complexity: Hallmarks of systemic disease

Cell, Год журнала: 2024, Номер 187(7), С. 1589 - 1616

Опубликована: Март 1, 2024

Язык: Английский

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