Distinction of lymphoid and myeloid clonal hematopoiesis

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(11), P. 1921 - 1927

Published: Oct. 18, 2021

Language: Английский

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Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure

Circulation Research, Journal Year: 2020, Volume and Issue: 128(2), P. 216 - 228

Published: Nov. 6, 2020

Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase 3a) is associated with increased incidence cardiovascular disease and poor prognosis patients chronic heart failure (HF) aortic stenosis. Although experimental studies suggest that clonal hematopoiesis-driver may enhance inflammation, specific signatures inflammatory cells in humans are missing.To define subsets immune mediating inflammation using single-cell RNA sequencing.Transcriptomic profiles peripheral blood mononuclear were analyzed n=6 HF harboring n=4 no sequencing. Monocytes carrying demonstrated a significantly expression genes compared monocytes derived from without mutations. Among the upregulated prototypic IL (interleukin) IL1B (interleukin 1B), IL6, IL8, inflammasome NLRP3, macrophage proteins CCL3 CCL4 as well resistin, which augments monocyte-endothelial adhesion. Silencing induced paracrine proinflammatory activation adhesion to endothelial cells. Furthermore, classical monocyte subset mutation carriers showed T-cell stimulating immunoglobulin superfamily members CD300LB, CD83, SIGLEC12, CD2 ligand cell molecule CD58, all be involved monocyte-T-cell interactions. further characterized alpha receptor constant chain changes T helper 1, 2, 17, CD8+ effector, CD4+ memory, regulatory T-cell-specific signatures.This study demonstrates circulating exhibit highly inflamed transcriptome, contribute aggravation HF.

Language: Английский

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Biomarkers of aging

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

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Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer

Cancer Cell, Journal Year: 2020, Volume and Issue: 38(6), P. 818 - 828.e5

Published: Oct. 23, 2020

Language: Английский

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Clonal expansion in non-cancer tissues

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(4), P. 239 - 256

Published: Feb. 24, 2021

Language: Английский

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Acute myeloid leukaemia

The Lancet, Journal Year: 2023, Volume and Issue: 401(10393), P. 2073 - 2086

Published: April 15, 2023

Language: Английский

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Common and rare variant associations with clonal haematopoiesis phenotypes

Nature, Journal Year: 2022, Volume and Issue: 612(7939), P. 301 - 309

Published: Nov. 30, 2022

Language: Английский

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Inflammation-Induced Tumorigenesis and Metastasis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(11), P. 5421 - 5421

Published: May 21, 2021

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms is now recognized as hallmark of cancer an attractive therapeutic target cancer. In this review, we discuss recent advances molecular how inflammation promotes suppresses anti-tumor immunity types solid tumors, including esophageal, gastric, colorectal, liver, pancreatic well hematopoietic malignancies.

Language: Английский

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Making sense of the ageing methylome

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(10), P. 585 - 605

Published: May 2, 2022

Language: Английский

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Precision medicine in non-small cell lung cancer: Current applications and future directions

Seminars in Cancer Biology, Journal Year: 2020, Volume and Issue: 84, P. 184 - 198

Published: July 27, 2020

Language: Английский

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