Dietary fibre in gastrointestinal health and disease

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2020, Номер 18(2), С. 101 - 116

Опубликована: Ноя. 18, 2020

Язык: Английский

---

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

Nutrients, Год журнала: 2019, Номер 11(12), С. 2862 - 2862

Опубликована: Ноя. 22, 2019

The human gut is inhabited by trillions of microorganisms composing a dynamic ecosystem implicated in health and disease. composition the microbiota unique to each individual tends remain relatively stable throughout life, yet daily transient fluctuations are observed. Diet key modifiable factor influencing microbiota, indicating potential for therapeutic dietary strategies manipulate microbial diversity, composition, stability. While diet can induce shift these changes appear be temporary. Whether prolonged permanent alterations unknown, mainly due lack long-term interventions, or follow-ups short-term interventions. It possible that habitual diets have greater influence on than acute strategies. This review presents current knowledge around response interventions identifies major factors contribute diet. Overall, further research include microbiome measures required before clinical recommendations made modulation health.

Язык: Английский

---

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2022, Номер 19(10), С. 625 - 637

Опубликована: Май 31, 2022

Язык: Английский

---

New insights from uncultivated genomes of the global human gut microbiome

Nature, Год журнала: 2019, Номер 568(7753), С. 505 - 510

Опубликована: Март 13, 2019

The genome sequences of many species the human gut microbiome remain unknown, largely owing to challenges in cultivating microorganisms under laboratory conditions. Here we address this problem by reconstructing 60,664 draft prokaryotic genomes from 3,810 faecal metagenomes, geographically and phenotypically diverse humans. These provide reference points for 2,058 newly identified species-level operational taxonomic units (OTUs), which represents a 50% increase over previously known phylogenetic diversity sequenced bacteria. On average, OTUs comprise 33% richness 28% abundance per individual, are enriched humans rural populations. A meta-analysis clinical gut-microbiome studies pinpointed numerous disease associations OTUs, have potential improve predictive models. Finally, our analysis revealed that uncultured undergone reduction has resulted loss certain biosynthetic pathways, may offer clues improving cultivation strategies future. Draft metagenomes populations enrich understanding identifying two thousand new taxa associations.

Язык: Английский

---

US Immigration Westernizes the Human Gut Microbiome

Cell, Год журнала: 2018, Номер 175(4), С. 962 - 972.e10

Опубликована: Ноя. 1, 2018

Язык: Английский

---

A practical guide to amplicon and metagenomic analysis of microbiome data

Protein & Cell, Год журнала: 2020, Номер 12(5), С. 315 - 330

Опубликована: Май 11, 2020

Abstract Advances in high-throughput sequencing (HTS) have fostered rapid developments the field of microbiome research, and massive datasets are now being generated. However, diversity software tools complexity analysis pipelines make it difficult to access this field. Here, we systematically summarize advantages limitations methods. Then, recommend specific for amplicon metagenomic analyses, describe commonly-used databases, help researchers select appropriate tools. Furthermore, introduce statistical visualization methods suitable analysis, including alpha- beta-diversity, taxonomic composition, difference comparisons, correlation, networks, machine learning, evolution, source tracing, common styles informed choices. Finally, a step-by-step reproducible guide is introduced. We hope review will allow carry out data more effectively quickly order efficiently mine biological significance behind data.

Язык: Английский

---

Reproducible molecular networking of untargeted mass spectrometry data using GNPS

Nature Protocols, Год журнала: 2020, Номер 15(6), С. 1954 - 1991

Опубликована: Май 13, 2020

Язык: Английский

---

Prevotella diversity, niches and interactions with the human host

Nature Reviews Microbiology, Год журнала: 2021, Номер 19(9), С. 585 - 599

Опубликована: Май 28, 2021

Язык: Английский

---

The Gut Microbiota in the First Decade of Life

Trends in Microbiology, Год журнала: 2019, Номер 27(12), С. 997 - 1010

Опубликована: Авг. 29, 2019

Appreciation of the importance gut microbiome is growing, and it becoming increasingly relevant to identify preventive or therapeutic solutions targeting it. The composition function microbiota are relatively well described for infants (less than 3 years) adults, but have been largely overlooked in pre-school (3-6 primary school-age (6-12 children, as teenagers (12-18 years). Early reports suggested that infant would attain an adult-like structure at age years, recent studies development may take longer. This time key because there evidence suggest deviations this consequences later life. In review, we provide overview current knowledge concerning microbiota, its evolution, variation, response dietary challenges during first decade life with a focus on healthy children (up 12 from various populations around globe. should facilitate identification diet-based approaches individuals group, promote

Язык: Английский

---

Comparing Microbiome Sampling Methods in a Wild Mammal: Fecal and Intestinal Samples Record Different Signals of Host Ecology, Evolution

Frontiers in Microbiology, Год журнала: 2018, Номер 9

Опубликована: Май 1, 2018

The gut microbiome is a community of host-associated symbiotic microbes that fulfills multiple key roles in host metabolism, immune function, and tissue development. Given the ability to impact fitness, there increasing interest studying wild animals better understand these communities context ecology evolution. Human research protocols are well established, but wildlife still developing field. Currently, no standardized set best practices guiding collection samples from wildlife. Gut microflora typically sampled either by fecal collection, rectal swabbing, or destructively sampling intestinal contents animal. Studies rarely include more than one technique comparison methods currently exists for mammal. Although some studies have hypothesized nested subset microbiome, this hypothesis has not been formally tested system. To address issues, we examined guano (feces) distal mucosa 17 species free-ranging bats Lamanai, Belize, using 16S rRNA amplicon sequencing compare microbial across sample types. We found diversity composition intestine differed substantially. In addition, conclude signatures evolution retained microbiomes based on mucosal samples, samples. Conversely, signal diet These results suggest interchangeable, two microbiotas record different information about which they isolated.

Язык: Английский

---