Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease DOI Creative Commons
Estella A. Newcombe, Judith Camats‐Perna,

Mallone L. Silva

и другие.

Journal of Neuroinflammation, Год журнала: 2018, Номер 15(1)

Опубликована: Сен. 24, 2018

Alzheimer’s disease (AD) is a neurodegenerative disorder, most cases of which lack clear causative event. This has made the difficult to characterize and, thus, diagnose. Although some are genetically linked, there many diseases and lifestyle factors that can lead an increased risk developing AD, including traumatic brain injury, diabetes, hypertension, obesity, other metabolic syndromes, in addition aging. Identifying common trends between these conditions could enhance our understanding AD development more effective treatments. immune system one body’s key defense mechanisms, chronic inflammation been increasingly linked with several age-related diseases. Moreover, it now well accepted important role onset progression AD. In this review, different inflammatory signals associated its will be outlined demonstrate how may influencing individual susceptibility Our goal bring attention potential shared presented by during successful

Язык: Английский

The Microbiota-Gut-Brain Axis DOI Open Access
John F. Cryan, Kenneth J. O’Riordan, Caitlin S.M. Cowan

и другие.

Physiological Reviews, Год журнала: 2019, Номер 99(4), С. 1877 - 2013

Опубликована: Авг. 28, 2019

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric

Язык: Английский

Процитировано

3523

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease DOI Creative Commons

Kassem Makki,

Edward C. Deehan, Jens Walter

и другие.

Cell Host & Microbe, Год журнала: 2018, Номер 23(6), С. 705 - 715

Опубликована: Июнь 1, 2018

Язык: Английский

Процитировано

1921

Role of the gut microbiota in nutrition and health DOI Creative Commons
Ana M. Valdes, Jens Walter, Eran Segal

и другие.

BMJ, Год журнала: 2018, Номер unknown, С. k2179 - k2179

Опубликована: Июнь 13, 2018

Role of the gut microbiota in nutrition and healthAna M Valdes colleagues discuss strategies for modulating

Язык: Английский

Процитировано

1914

The gut-liver axis in liver disease: Pathophysiological basis for therapy DOI Creative Commons
Agustı́n Albillos, Andrea De Gottardi, María Rescigno

и другие.

Journal of Hepatology, Год журнала: 2019, Номер 72(3), С. 558 - 577

Опубликована: Окт. 15, 2019

The gut-liver axis refers to the bidirectional relationship between gut and its microbiota, liver, resulting from integration of signals generated by dietary, genetic environmental factors. This reciprocal interaction is established portal vein which enables transport gut-derived products directly liver feedback route bile antibody secretion intestine. intestinal mucosal vascular barrier functional anatomical structure that serves as a playground for interactions limiting systemic dissemination microbes toxins while allowing nutrients access circulation reach liver. control microbial communities critical maintaining homeostasis axis, part this communication shapes communities. Alcohol disrupts at multiple interconnected levels, including microbiome, mucus barrier, epithelial level antimicrobial peptide production, increases exposure proinflammatory environment Growing evidence indicates pathogenetic role microbe-derived metabolites, such trimethylamine, secondary acids, short-chain fatty acids ethanol, in pathogenesis non-alcoholic disease. Cirrhosis itself associated with profound alterations microbiota damage different levels defence epithelial, immune barriers. relevance severe disturbance cirrhosis has been linked translocation live bacteria, bacterial infections disease progression. identification elements primarily damaged each chronic offers possibilities intervention. Beyond antibiotics, upcoming therapies centred on include new generations probiotics, metabolites (postbiotics), faecal transplantation, carbon nanoparticles. FXR-agonists target both are currently being tested diseases. Finally, synthetic biotic medicines, phages specific bacteria or create physical barriers offer therapeutic approaches.

Язык: Английский

Процитировано

1454

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases DOI
Serena Sanna, Natalie R. van Zuydam, Anubha Mahajan

и другие.

Nature Genetics, Год журнала: 2019, Номер 51(4), С. 600 - 605

Опубликована: Фев. 18, 2019

Язык: Английский

Процитировано

1217

Gut microbial metabolites in obesity, NAFLD and T2DM DOI
Emanuel E. Canfora, Ruth C. R. Meex, Koen Venema

и другие.

Nature Reviews Endocrinology, Год журнала: 2019, Номер 15(5), С. 261 - 273

Опубликована: Янв. 22, 2019

Язык: Английский

Процитировано

1139

Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease DOI Creative Commons
Alan Chait, Laura J. den Hartigh

Frontiers in Cardiovascular Medicine, Год журнала: 2020, Номер 7

Опубликована: Фев. 25, 2020

Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose have been identified, namely white, brown, beige, that reside various specific anatomical locations throughout the body. The cellular composition, secretome, location these depots define their function health metabolic disease. In obesity, becomes dysfunctional, promoting a pro-inflammatory, hyperlipidemic insulin resistant environment contributes to type 2 diabetes mellitus (T2DM). Concurrently, similar features result from dysfunction also promote cardiovascular disease (CVD) by mechanisms can be augmented T2DM. which dysfunctional simultaneously T2DM CVD, focusing on depot-specific adipokines, inflammatory profiles, metabolism, will focus this review. impact CVD treatment strategies body weight discussed.

Язык: Английский

Процитировано

1057

The microbiome, cancer, and cancer therapy DOI
Beth A. Helmink, Md Abdul Wadud Khan,

Amanda Hermann

и другие.

Nature Medicine, Год журнала: 2019, Номер 25(3), С. 377 - 388

Опубликована: Март 1, 2019

Язык: Английский

Процитировано

979

SCFA: mechanisms and functional importance in the gut DOI Open Access
Camille Martin‐Gallausiaux, Ludovica Marinelli, Hervé M. Blottière

и другие.

Proceedings of The Nutrition Society, Год журнала: 2020, Номер 80(1), С. 37 - 49

Опубликована: Апрель 2, 2020

In recent years, the importance of gut microbiota in human health has been revealed and many publications have highlighted its role as a key component physiology. Owing to use modern sequencing approaches, characterisation microbiome healthy individuals disease demonstrated disturbance microbiota, or dysbiosis, associated with pathological conditions. The establishes symbiotic crosstalk their host: commensal microbes benefit from nutrient-rich environment provided by produces hundreds proteins metabolites that modulate functions host, including nutrient processing, maintenance energy homoeostasis immune system development. Many bacteria-derived originate dietary sources. Among them, an important attributed derived bacterial fermentation fibres, namely SCFA linking host nutrition intestinal maintenance. are fuels for epithelial cells (IEC) regulate IEC through different mechanisms proliferation, differentiation well subpopulations such enteroendocrine cells, impact motility strengthen barrier metabolism. Recent findings show SCFA, particular butyrate, also immuno-modulatory functions. this review, we discuss on immunity consequently health.

Язык: Английский

Процитировано

967

Human gut microbiota/microbiome in health and diseases: a review DOI
Eman Zakaria Gomaa

Antonie van Leeuwenhoek, Год журнала: 2020, Номер 113(12), С. 2019 - 2040

Опубликована: Ноя. 2, 2020

Язык: Английский

Процитировано

943