Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain

Physiological Reviews, Год журнала: 2020, Номер 101(1), С. 213 - 258

Опубликована: Июнь 11, 2020

Chronic, pathological pain remains a global health problem and challenge to basic clinical sciences. A major obstacle preventing, treating, or reverting chronic has been that the nature of neural circuits underlying diverse components complex, multidimensional experience is not well understood. Moreover, involves maladaptive plasticity processes, which have decoded mechanistically in terms involvement specific cause-effect relationships. This review aims discuss recent advances our understanding circuit connectivity mammalian brain at level regional contributions cell types acute pain. focus placed on functional dissection sub-neocortical using optogenetics, chemogenetics, imaging technological tools rodent models with view towards decoding sensory, affective, motivational-cognitive dimensions The summarizes breakthroughs insights structure-function properties nociceptive higher order modulatory involved aversion, learning, reward, mood their modulation by endogenous GABAergic inhibition, noradrenergic, cholinergic, dopaminergic, serotonergic, peptidergic pathways. knowledge dynamic regulation via structural will be beneficial designing improving targeted therapies.

Язык: Английский

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Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment

Neuron, Год журнала: 2019, Номер 101(5), С. 783 - 800

Опубликована: Март 1, 2019

Язык: Английский

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Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain

JAMA Psychiatry, Год журнала: 2021, Номер 79(1), С. 13 - 13

Опубликована: Сен. 29, 2021

Importance

Chronic back pain (CBP) is a leading cause of disability, and treatment often ineffective. Approximately 85% cases are primary CBP, for which peripheral etiology cannot be identified, maintenance factors include fear, avoidance, beliefs that indicates injury.

Objective

To test whether psychological (pain reprocessing therapy [PRT]) aiming to shift patients’ about the causes threat value provides substantial durable relief from CBP investigate mechanisms.

Design, Setting, Participants

This randomized clinical trial with longitudinal functional magnetic resonance imaging (fMRI) 1-year follow-up assessment was conducted in university research setting November 2017 August 2018, completed by 2019. Clinical fMRI data were analyzed January 2019 2020. The study compared PRT an open-label placebo usual care community sample.

Interventions

Participants participated 1 telehealth session physician 8 sessions over 4 weeks. Treatment aimed help patients reconceptualize their as due nondangerous brain activity rather than tissue injury, using combination cognitive, somatic, exposure-based techniques. received subcutaneous saline injection back; participants continued routine, ongoing care.

Main Outcomes Measures

One-week mean intensity score (0 10) at posttreatment, beliefs, measures evoked resting connectivity.

Results

At baseline, 151 adults (54% female; [SD] age, 41.1 [15.6] years) reported (SD) low moderate severity (mean intensity, 4.10 [1.26] 10; 23.34 [10.12] 100) duration 10.0 (8.9) years. Large group differences observed 1.18 (1.24) group, 2.84 (1.64) 3.13 (1.45) group. Hedgesgwas −1.14 vs −1.74 (P < .001). Of total participants, 33 50 (66%) pain-free or nearly posttreatment (reporting 0 10), 10 51 (20%) 5 (10%) effects maintained follow-up, 1.51 (1.59) 2.79 (1.78) 3.00 (1.77) −0.70 = .001) −1.05 follow-up. Longitudinal showed (1) reduced responses anterior midcingulate prefrontal cortex placebo; (2) insula care; (3) increased connectivity somatosensory both control groups; (4) precuneus

Conclusions Relevance

Psychological centered on changing may provide people CBP.

Trial Registration

ClinicalTrials.gov Identifier:NCT03294148.

Язык: Английский

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The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities

Biological Psychiatry, Год журнала: 2019, Номер 87(1), С. 64 - 73

Опубликована: Дек. 2, 2019

Язык: Английский

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Amygdala, neuropeptides, and chronic pain-related affective behaviors

Neuropharmacology, Год журнала: 2020, Номер 170, С. 108052 - 108052

Опубликована: Март 15, 2020

Язык: Английский

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Brain circuits for pain and its treatment

Science Translational Medicine, Год журнала: 2021, Номер 13(619)

Опубликована: Ноя. 10, 2021

Understanding the organization of brain’s pain circuits is critical for developing effective treatments patients suffering from chronic pain.

Язык: Английский

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Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential

Pharmacology & Therapeutics, Год журнала: 2020, Номер 212, С. 107581 - 107581

Опубликована: Май 22, 2020

Язык: Английский

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Fluorescence imaging of large-scale neural ensemble dynamics

Cell, Год журнала: 2022, Номер 185(1), С. 9 - 41

Опубликована: Янв. 1, 2022

Язык: Английский

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Neocortical circuits in pain and pain relief

Nature reviews. Neuroscience, Год журнала: 2021, Номер 22(8), С. 458 - 471

Опубликована: Июнь 14, 2021

Язык: Английский

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Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states

Nature Neuroscience, Год журнала: 2021, Номер 24(4), С. 542 - 553

Опубликована: Март 8, 2021

Язык: Английский

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