PAIN Reports,
Год журнала:
2021,
Номер
6(1), С. e905 - e905
Опубликована: Янв. 1, 2021
Abstract
Chronic
pain
is
an
unpleasant
and
debilitating
condition
that
often
poorly
managed
by
existing
therapeutics.
Reciprocal
interactions
between
the
nervous
system
immune
have
been
recognized
as
playing
essential
role
in
initiation
maintenance
of
pain.
In
this
review,
we
discuss
how
neuroimmune
signaling
can
contribute
to
peripheral
central
sensitization
promote
chronic
through
various
autoimmune
mechanisms.
These
pathogenic
mechanisms
involve
production
release
autoreactive
antibodies
from
B
cells.
Autoantibodies—ie,
recognize
self-antigens—have
identified
potential
molecules
modulate
function
nociceptive
neurons
thereby
induce
persistent
Autoantibodies
influence
neuronal
excitability
activating
complement
pathway;
directly
at
sensory
expressing
Fc
gamma
receptors,
receptors
for
fragment
immunoglobulin
G
complexes;
or
binding
disrupting
ion
channels
expressed
nociceptors.
Using
examples
primarily
rheumatoid
arthritis,
complex
regional
syndrome,
channelopathies
potassium
channel
autoimmunity,
suggest
autoantibody
has
therapeutic
implications
designing
novel
disease-modifying
treatments
Neuroimmune
cross-talk
participates
in
intestinal
tissue
homeostasis
and
host
defense.
However,
the
matrix
of
interactions
between
arrays
molecularly
defined
neuron
subsets
immunocyte
lineages
remains
unclear.
We
used
a
chemogenetic
approach
to
activate
eight
distinct
neuronal
subsets,
assessing
effects
by
deep
immunophenotyping,
microbiome
profiling,
transcriptomics
organs.
Distinct
immune
perturbations
followed
activation:
Nitrergic
neurons
regulated
T
helper
17
(T
The Journal of Headache and Pain,
Год журнала:
2025,
Номер
26(1)
Опубликована: Янв. 20, 2025
Migraine
is
a
complex
neurological
disorder
characterized
by
recurrent
episodes
of
severe
headaches.
Although
genetic
factors
have
been
implicated,
the
precise
molecular
mechanisms,
particularly
gene
expression
patterns
in
migraine-associated
brain
regions,
remain
unclear.
This
study
applies
machine
learning
techniques
to
explore
region-specific
profiles
and
identify
critical
programs
transcription
linked
migraine
pathogenesis.
We
utilized
single-nucleus
RNA
sequencing
(snRNA-seq)
data
from
43
along
with
genome-wide
association
(GWAS)
data,
investigate
susceptibility
migraine.
The
cell-type-specific
(CELLEX)
algorithm
was
employed
calculate
specific
for
each
region,
while
non-negative
matrix
factorization
(NMF)
applied
decompose
within
single-cell
these
regions.
Following
annotation
region
genome,
we
stratified
linkage
disequilibrium
score
regression
(S-LDSC)
assess
associations
between
programs,
migraine-related
SNPs.
Key
regulating
were
identified
using
random
forest
model
based
on
regulatory
networks
derived
GTEx
consortium.
Our
analysis
revealed
significant
enrichment
single
nucleotide
polymorphisms
(SNPs)
posterior
nuclear
complex-medial
geniculate
nuclei
(PoN_MG)
thalamus,
highlighting
this
region's
crucial
role
Gene
program
1,
through
NMF,
enriched
calcium
signaling
pathway,
known
contributor
pathophysiology.
Random
predicted
ARID3A
as
top
factor
suggesting
its
potential
modulating
calcium-related
genes
involved
provides
new
insights
into
mechanisms
underlying
migraine,
emphasizing
importance
PoN_MG
thalamic
pathways,
key
like
ARID3A.
These
findings
offer
avenues
developing
targeted
therapeutic
strategies
treatment.
Frontiers in Psychiatry,
Год журнала:
2021,
Номер
12
Опубликована: Апрель 12, 2021
The
bidirectional
relationship
between
depression
and
chronic
pain
is
well-recognized,
but
their
clinical
management
remains
challenging.
Here
we
characterize
the
shared
risk
factors
outcomes
for
comorbidity
in
Australian
Genetics
of
Depression
cohort
study
(
Pain,
Год журнала:
2022,
Номер
164(6), С. 1200 - 1221
Опубликована: Ноя. 21, 2022
Reliable
and
objective
biomarkers
promise
to
improve
the
assessment
treatment
of
chronic
pain.
Resting-state
electroencephalography
(EEG)
is
broadly
available,
easy
use,
cost
efficient
and,
therefore,
appealing
as
a
potential
biomarker
However,
results
EEG
studies
are
heterogeneous.
Therefore,
we
conducted
systematic
review
(PROSPERO
CRD42021272622)
quantitative
resting-state
magnetoencephalography
(MEG)
in
adult
patients
with
different
types
We
excluded
populations
severe
psychiatric
or
neurologic
comorbidity.
Risk
bias
was
assessed
using
modified
Newcastle-Ottawa
Scale.
Semiquantitative
data
synthesis
albatross
plots.
included
76
after
searching
MEDLINE,
Web
Science
Core
Collection,
Cochrane
Central
Register
Controlled
Trials,
EMBASE.
For
cross-sectional
that
can
serve
develop
diagnostic
biomarkers,
found
higher
theta
beta
power
pain
than
healthy
participants.
longitudinal
studies,
which
yield
monitoring
and/or
predictive
no
clear
associations
relief
M/EEG
measures.
Similarly,
descriptive
showed
correlations
intensity
high
many
domains.
Together,
this
synthesizes
evidence
on
how
might
Beyond,
help
guide
future
development
biomarkers.
