Annual Review of Cell and Developmental Biology,
Год журнала:
2019,
Номер
35(1), С. 357 - 379
Опубликована: Июль 8, 2019
Eukaryotic
transcription
factors
(TFs)
from
the
same
structural
family
tend
to
bind
similar
DNA
sequences,
despite
ability
of
these
TFs
execute
distinct
functions
in
vivo.
The
cell
partly
resolves
this
specificity
paradox
through
combinatorial
strategies
and
use
low-affinity
binding
sites,
which
are
better
able
distinguish
between
TFs.
However,
because
sites
have
low
affinity,
it
is
challenging
understand
how
recognize
them
Here,
we
summarize
recent
findings
technological
advancements
that
allow
for
quantification
mechanistic
interpretation
TF
recognition
across
a
wide
range
affinities.
We
propose
model
integrates
insights
fields
genetics
biology
provide
further
conceptual
understanding
specificity.
argue
eukaryotes,
target
driven
by
an
inhomogeneous
3D
nuclear
distribution
variation
affinity
such
locally
elevated
concentration
allows
be
functional.
Science,
Год журнала:
2018,
Номер
361(6409), С. 1346 - 1349
Опубликована: Сен. 28, 2018
RNA
modifications
have
recently
emerged
as
critical
posttranscriptional
regulators
of
gene
expression
programs.
They
affect
diverse
eukaryotic
biological
processes,
and
the
correct
deposition
many
these
is
required
for
normal
development.
Messenger
(mRNA)
regulate
various
aspects
mRNA
metabolism.
For
example,
Signal Transduction and Targeted Therapy,
Год журнала:
2021,
Номер
6(1)
Опубликована: Авг. 1, 2021
Abstract
Emerging
evidence
suggests
that
liquid–liquid
phase
separation
(LLPS)
represents
a
vital
and
ubiquitous
phenomenon
underlying
the
formation
of
membraneless
organelles
in
eukaryotic
cells
(also
known
as
biomolecular
condensates
or
droplets).
Recent
studies
have
revealed
evidences
indicate
LLPS
plays
role
human
health
diseases.
In
this
review,
we
describe
our
current
understanding
summarize
its
physiological
functions.
We
further
development
Additionally,
review
recently
developed
methods
for
studying
LLPS.
Although
research
is
infancy—but
fast-growing—it
clear
an
essential
pathophysiological
conditions.
This
highlights
need
overview
recent
advances
field
to
translate
knowledge
regarding
into
therapeutic
discoveries.
