Science,
Год журнала:
2024,
Номер
383(6690), С. 1478 - 1483
Опубликована: Март 28, 2024
Experiences
need
to
be
tagged
during
learning
for
further
consolidation.
However,
neurophysiological
mechanisms
that
select
experiences
lasting
memory
are
not
known.
By
combining
large-scale
neural
recordings
in
mice
with
dimensionality
reduction
techniques,
we
observed
successive
maze
traversals
were
tracked
by
continuously
drifting
populations
of
neurons,
providing
neuronal
signatures
both
places
visited
and
events
encountered.
When
the
brain
state
changed
reward
consumption,
sharp
wave
ripples
(SPW-Rs)
occurred
on
some
trials,
their
specific
spike
content
decoded
trial
blocks
surrounded
them.
During
postexperience
sleep,
SPW-Rs
continued
replay
those
reactivated
most
frequently
waking
SPW-Rs.
Replay
awake
may
thus
provide
a
tagging
mechanism
aspects
experience
preserved
consolidated
future
use.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Май 12, 2021
Abstract
Neurostimulant
drugs
or
magnetic/electrical
stimulation
techniques
can
overcome
attention
deficits,
but
these
are
weakly
beneficial
in
boosting
the
learning
capabilities
of
healthy
subjects.
Here,
we
report
a
technique,
mid-infrared
modulation
(MIM),
that
delivers
light
energy
through
opened
skull
even
non-invasively
thinned
intact
and
activate
brain
neurons
vivo
without
introducing
any
exogeneous
gene.
Using
c-Fos
immunohistochemistry,
single-cell
electrophysiology
two-photon
Ca
2+
imaging
mice,
demonstrate
MIM
significantly
induces
firing
activities
targeted
cortical
area.
Moreover,
mice
receive
targeting
to
auditory
cortex
during
an
associative
task
exhibit
faster
speed
(~50%
faster)
than
control
mice.
Together,
this
non-invasive,
opsin-free
technique
is
demonstrated
with
potential
for
modulating
neuronal
activity.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Март 13, 2020
Abstract
In
contextual
fear
conditioning,
experimental
subjects
learn
to
associate
a
neutral
context
with
an
aversive
stimulus
and
display
responses
that
predicts
danger.
Although
the
hippocampal–amygdala
pathway
has
been
implicated
in
retrieval
of
memory,
mechanism
by
which
memory
is
encoded
this
circuit
not
investigated.
Here,
we
show
activity
ventral
CA1
(vCA1)
hippocampal
projections
basal
amygdala
(BA),
paired
stimuli,
contributes
encoding
conditioned
memory.
Contextual
conditioning
induced
selective
strengthening
subset
vCA1–BA
synapses,
was
prevented
under
anisomycin-induced
retrograde
amnesia.
Moreover,
subpopulation
BA
neurons
receives
stronger
monosynaptic
inputs
from
context-responding
vCA1
neurons,
whose
required
for
learning
synaptic
potentiation
pathway.
Our
study
suggests
conveying
information
adaptive
threat-predictive
context.
Science,
Год журнала:
2020,
Номер
367(6483), С. 1230 - 1234
Опубликована: Март 12, 2020
How
amyloid
can
be
a
substrate
of
memory
Formation
memories
requires
changes
in
the
molecular
composition
synapse.
these
occur
and
what
maintains
this
altered
synaptic
so
that
persist
are
unknown.
Hervas
et
al.
report
structure
translation
regulator
called
Orb2
isolated
from
brains
adult
fruit
flies
is
important
for
maintenance
recall
memory.
forms
an
its
activity
repressor
to
activator.
The
core
composed
polar
hydrophilic
residues,
as
opposed
hydrophobic
ones
found
nonfunctional
or
pathological
amyloids.
provides
insights
into
how
amyloids
could
stable
yet
malleable
Science
,
issue
p.
1230
