Neuronal ensembles: Building blocks of neural circuits DOI Creative Commons
Rafael Yuste, Rosa Cossart, Emre Yaksi

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(6), P. 875 - 892

Published: Jan. 22, 2024

Language: Английский

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity DOI Creative Commons
Phi T. Nguyen, Leah C. Dorman, Simon Pan

et al.

Cell, Journal Year: 2020, Volume and Issue: 182(2), P. 388 - 403.e15

Published: July 1, 2020

Language: Английский

Citations

477
Encoding of contextual fear memory in hippocampal–amygdala circuit DOI Creative Commons
Woong Bin Kim, Jun-Hyeong Cho

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: March 13, 2020

Abstract In contextual fear conditioning, experimental subjects learn to associate a neutral context with an aversive stimulus and display responses that predicts danger. Although the hippocampal–amygdala pathway has been implicated in retrieval of memory, mechanism by which memory is encoded this circuit not investigated. Here, we show activity ventral CA1 (vCA1) hippocampal projections basal amygdala (BA), paired stimuli, contributes encoding conditioned memory. Contextual conditioning induced selective strengthening subset vCA1–BA synapses, was prevented under anisomycin-induced retrograde amnesia. Moreover, subpopulation BA neurons receives stronger monosynaptic inputs from context-responding vCA1 neurons, whose required for learning synaptic potentiation pathway. Our study suggests conveying information adaptive threat-predictive context.

Language: Английский

Citations

222
Non-invasive, opsin-free mid-infrared modulation activates cortical neurons and accelerates associative learning DOI Creative Commons
Jianxiong Zhang,

Yong He,

Shanshan Liang

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 12, 2021

Abstract Neurostimulant drugs or magnetic/electrical stimulation techniques can overcome attention deficits, but these are weakly beneficial in boosting the learning capabilities of healthy subjects. Here, we report a technique, mid-infrared modulation (MIM), that delivers light energy through opened skull even non-invasively thinned intact and activate brain neurons vivo without introducing any exogeneous gene. Using c-Fos immunohistochemistry, single-cell electrophysiology two-photon Ca 2+ imaging mice, demonstrate MIM significantly induces firing activities targeted cortical area. Moreover, mice receive targeting to auditory cortex during an associative task exhibit faster speed (~50% faster) than control mice. Together, this non-invasive, opsin-free technique is demonstrated with potential for modulating neuronal activity.

Language: Английский

Citations

217
Insular cortex neurons encode and retrieve specific immune responses DOI Creative Commons
Tamar Koren, Re’ee Yifa,

M. Amer

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(24), P. 5902 - 5915.e17

Published: Nov. 1, 2021

Language: Английский

Citations

214
Amygdala Reward Neurons Form and Store Fear Extinction Memory DOI Creative Commons
Xiangyu Zhang, Joshua Kim, Susumu Tonegawa

et al.

Neuron, Journal Year: 2020, Volume and Issue: 105(6), P. 1077 - 1093.e7

Published: Jan. 14, 2020

Language: Английский

Citations

196
Encouraging an excitable brain state: mechanisms of brain repair in stroke DOI
Mary T. Joy, S. Thomas Carmichael

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 22(1), P. 38 - 53

Published: Nov. 12, 2020

Language: Английский

Citations

185
Attractor and integrator networks in the brain DOI

Mikail Khona,

Ila Fiete

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(12), P. 744 - 766

Published: Nov. 3, 2022

Language: Английский

Citations

184
Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila DOI Open Access
Rubén Hervás, Michael Rau,

Younshim Park

et al.

Science, Journal Year: 2020, Volume and Issue: 367(6483), P. 1230 - 1234

Published: March 12, 2020

How amyloid can be a substrate of memory Formation memories requires changes in the molecular composition synapse. these occur and what maintains this altered synaptic so that persist are unknown. Hervas et al. report structure translation regulator called Orb2 isolated from brains adult fruit flies is important for maintenance recall memory. forms an its activity repressor to activator. The core composed polar hydrophilic residues, as opposed hydrophobic ones found nonfunctional or pathological amyloids. provides insights into how amyloids could stable yet malleable Science , issue p. 1230

Language: Английский

Citations

171
An Integrated Index: Engrams, Place Cells, and Hippocampal Memory DOI Creative Commons
Travis D. Goode, Kazumasa Z. Tanaka, Amar Sahay

et al.

Neuron, Journal Year: 2020, Volume and Issue: 107(5), P. 805 - 820

Published: Aug. 6, 2020

Language: Английский

Citations

153
No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory DOI Creative Commons
Asaf Gilboa, Morris Moscovitch

Neuron, Journal Year: 2021, Volume and Issue: 109(14), P. 2239 - 2255

Published: May 19, 2021

Language: Английский

Citations

130