Common variants contribute to intrinsic human brain functional networks

Nature Genetics, Год журнала: 2022, Номер 54(4), С. 508 - 517

Опубликована: Апрель 1, 2022

Язык: Английский

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Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(35)

Опубликована: Авг. 23, 2022

The use of spoken and written language is a fundamental human capacity. Individual differences in reading- language-related skills are influenced by genetic variation, with twin-based heritability estimates 30 to 80% depending on the trait. architecture complex, heterogeneous, multifactorial, but investigations contributions single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present multicohort genome-wide association study (GWAS) five traits assessed individually using psychometric measures (word reading, nonword spelling, phoneme awareness, repetition) samples 13,633 33,959 participants aged 5 26 y. identified significant word reading (rs11208009,

Язык: Английский

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Effects of urban living environments on mental health in adults

Nature Medicine, Год журнала: 2023, Номер 29(6), С. 1456 - 1467

Опубликована: Июнь 1, 2023

Abstract Urban-living individuals are exposed to many environmental factors that may combine and interact influence mental health. While individual of an urban environment have been investigated in isolation, no attempt has made model how complex, real-life exposure living the city relates brain health, this is moderated by genetic factors. Using data 156,075 participants from UK Biobank, we carried out sparse canonical correlation analyses investigate relationships between environments psychiatric symptoms. We found profile social deprivation, air pollution, street network land-use density was positively correlated with affective symptom group ( r = 0.22, P perm < 0.001), mediated volume differences consistent reward processing, genes enriched for stress response, including CRHR1 , explaining 2.01% variance differences. Protective such as greenness generous destination accessibility were negatively anxiety 0.10, regions necessary emotion regulation EXD3 1.65% variance. The third emotional instability 0.03, 0.001). Our findings suggest different profiles specific groups through distinct neurobiological pathways.

Язык: Английский

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Annual Research Review: Perspectives on progress in ADHD science – from characterization to cause

Journal of Child Psychology and Psychiatry, Год журнала: 2022, Номер 64(4), С. 506 - 532

Опубликована: Окт. 11, 2022

The science of attention‐deficit/hyperactivity disorder (ADHD) is motivated by a translational goal – the discovery and exploitation knowledge about nature ADHD to benefit those individuals whose lives it affects. Over past fifty years, scientific research has made enormous strides in characterizing condition understanding its correlates causes. However, translation these insights into clinical benefits been limited. In this review, we provide selective focused survey field ADHD, providing our personal perspectives on what constitutes consensus, important new leads be highlighted, key outstanding questions addressed going forward. We cover two broad domains characterization and, risk factors, causal processes neuro‐biological pathways . Part one focuses developmental course co‐occurring characteristics conditions, functional impact living with including impairment, quality life, stigma. part two, explore genetic environmental influences putative mediating brain processes. final section, reflect future construct light cross‐cutting themes recent conceptual reformulations that cast traits as broader spectrum neurodivergence.

Язык: Английский

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Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Biological Psychiatry, Год журнала: 2022, Номер 92(9), С. 730 - 738

Опубликована: Июнь 1, 2022

Язык: Английский

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