Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(9), P. 730 - 738
Published: June 1, 2022
Language: Английский
Nature Genetics, Journal Year: 2022, Volume and Issue: 54(4), P. 508 - 517
Published: April 1, 2022
Language: Английский
Citations
90
Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(35)
Published: Aug. 23, 2022
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- language-related skills are influenced by genetic variation, with twin-based heritability estimates 30 to 80% depending on the trait. architecture complex, heterogeneous, multifactorial, but investigations contributions single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present multicohort genome-wide association study (GWAS) five traits assessed individually using psychometric measures (word reading, nonword spelling, phoneme awareness, repetition) samples 13,633 33,959 participants aged 5 26 y. identified significant word reading (rs11208009,
Language: Английский
Citations
90
Nature Medicine, Journal Year: 2023, Volume and Issue: 29(6), P. 1456 - 1467
Published: June 1, 2023
Abstract Urban-living individuals are exposed to many environmental factors that may combine and interact influence mental health. While individual of an urban environment have been investigated in isolation, no attempt has made model how complex, real-life exposure living the city relates brain health, this is moderated by genetic factors. Using data 156,075 participants from UK Biobank, we carried out sparse canonical correlation analyses investigate relationships between environments psychiatric symptoms. We found profile social deprivation, air pollution, street network land-use density was positively correlated with affective symptom group ( r = 0.22, P perm < 0.001), mediated volume differences consistent reward processing, genes enriched for stress response, including CRHR1 , explaining 2.01% variance differences. Protective such as greenness generous destination accessibility were negatively anxiety 0.10, regions necessary emotion regulation EXD3 1.65% variance. The third emotional instability 0.03, 0.001). Our findings suggest different profiles specific groups through distinct neurobiological pathways.
Language: Английский
Citations
86
Journal of Child Psychology and Psychiatry, Journal Year: 2022, Volume and Issue: 64(4), P. 506 - 532
Published: Oct. 11, 2022
The science of attention‐deficit/hyperactivity disorder (ADHD) is motivated by a translational goal – the discovery and exploitation knowledge about nature ADHD to benefit those individuals whose lives it affects. Over past fifty years, scientific research has made enormous strides in characterizing condition understanding its correlates causes. However, translation these insights into clinical benefits been limited. In this review, we provide selective focused survey field ADHD, providing our personal perspectives on what constitutes consensus, important new leads be highlighted, key outstanding questions addressed going forward. We cover two broad domains characterization and, risk factors, causal processes neuro‐biological pathways . Part one focuses developmental course co‐occurring characteristics conditions, functional impact living with including impairment, quality life, stigma. part two, explore genetic environmental influences putative mediating brain processes. final section, reflect future construct light cross‐cutting themes recent conceptual reformulations that cast traits as broader spectrum neurodivergence.
Language: Английский
Citations
84
Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(9), P. 730 - 738
Published: June 1, 2022
Language: Английский
Citations
83