Embedding risk monitoring in infectious disease surveillance for timely and effective outbreak prevention and control DOI Creative Commons
Brecht Ingelbeen, Esther van Kleef,

Placide Mbala

и другие.

BMJ Global Health, Год журнала: 2025, Номер 10(2), С. e016870 - e016870

Опубликована: Фев. 1, 2025

Epidemic intelligence efforts aim to predict, timely detect and assess (re-)emerging pathogens, guide evaluate infectious disease prevention or control. We emphasise the underused potential of integrating monitoring risks related exposure, death, particularly in settings where limited diagnostic capacity access healthcare hamper prevention/control measures. Monitoring One Health exposures, human behaviour, immunity, comorbidities, uptake control measures pathogen characteristics can complement facility-based surveillance generating signals imminent ongoing outbreaks, targeting preventive/control interventions epidemic preparedness high-risk areas subpopulations. Low-cost risk data sources include electronic medical records, existing household/patient/environmental surveys, Demographic Surveillance Systems, medicine distribution programmatic data. Public health authorities need identify prioritise that effectively fill gaps not accurately answer, determine indicators generate from data, ensure availability, regular analysis dissemination.

Язык: Английский

Antibiotic resistance in the environment DOI Open Access
D. G. Joakim Larsson, Carl‐Fredrik Flach

Nature Reviews Microbiology, Год журнала: 2021, Номер 20(5), С. 257 - 269

Опубликована: Ноя. 4, 2021

Язык: Английский

Процитировано

1795

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level DOI Creative Commons

Natalie Sims,

Barbara Kasprzyk‐Hordern

Environment International, Год журнала: 2020, Номер 139, С. 105689 - 105689

Опубликована: Апрель 4, 2020

Infectious diseases are acknowledged as one of the most critical threats to global public health today. Climate change, unprecedented population growth with accelerated rates antimicrobial resistance, have resulted in both emergence novel pathogenic organisms and re-emergence infections that were once controlled. The consequences led an increased vulnerability infectious globally. ability rapidly monitor spread is key for prevention, intervention control, however several limitations exist current surveillance systems capacity cope rapid environmental changes. Wastewater-Based Epidemiology (WBE) a new epidemiology tool has potential act complementary approach disease early warning system outbreaks. WBE postulates through analysis pooled wastewater, resistance spread, outbreak community level can be monitored comprehensively real-time. This manuscript provides overview status, well it introduces its recent advancements. It also recommendations further development required application effective surveillance.

Язык: Английский

Процитировано

583

Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance DOI Creative Commons
Patrick Munk, Christian Brinch, Frederik Duus Møller

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Дек. 1, 2022

Abstract Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic genes (ARGs) essential develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing analyse ARGs in 757 sewage samples from 243 cities 101 countries, collected 2016 2019. We find regional patterns resistomes, these differ between subsets corresponding drug classes are partly driven by taxonomic variation. The genetic environments 49 common highly diverse, with most carried multiple distinct genomic contexts globally sometimes on plasmids. Analysis flanking sequence revealed ARG-specific dispersal limitation transmission. Our data furthermore suggest certain geographies more prone events should receive additional attention.

Язык: Английский

Процитировано

179

Emergent crisis of antibiotic resistance: A silent pandemic threat to 21st century DOI

Fatima Akram,

Memoona Imtiaz,

Ikram ul Haq

и другие.

Microbial Pathogenesis, Год журнала: 2022, Номер 174, С. 105923 - 105923

Опубликована: Дек. 13, 2022

Язык: Английский

Процитировано

120

Wastewater surveillance of antibiotic-resistant bacterial pathogens: A systematic review DOI Creative Commons
Ananda Tiwari, Paula Kurittu, Ahmad Ibrahim Al‐Mustapha

и другие.

Frontiers in Microbiology, Год журнала: 2022, Номер 13

Опубликована: Дек. 15, 2022

Infectious diseases caused by antibiotic-resistant bacterial (ARB) pathogens are a serious threat to human and animal health. The active surveillance of ARB using an integrated one-health approach can help reduce the emergence spread ARB, associated economic impact, guide antimicrobial stewardship programs. Wastewater (WWS) provides composite samples for total population, with easy access mixed community microbiome. This concept is emerging rapidly, but clinical utility, sensitivity, uniformity WWS remain poorly understood especially in relation evidence sewershed communities. Here, we systematically searched literature identify studies that have compared findings from antibiotic resistance genes (ARG) parallel, thereby evaluating how likely ARG relate cases Initially, 2,235 articles were obtained primary search keywords, 1,219 remained after de-duplication. Among these, 35 fulfilled criteria, additional 13 relevant included searching references literature. 48 papers, 34 used culture-based method, followed 11 metagenomics, three PCR-based methods. A 28 out conducted at single level, eight involved several countries, seven national or regional scales, five hospital levels. Our review revealed performance has been evaluated more frequently Escherichia coli, Enterococcus spp., other members family Enterobacteriaceae , not uniformly tested all pathogens. Many wastewater-based comparing evaluate public health risk ARB. Indeed, relating straightforward, as source wastewater cannot be only symptomatic individuals also asymptomatic carriers well sources. Further, varying fates each species within sewerage make aim connecting complicated. Therefore, future many AMR their one process simpler interpretation results easier.

Язык: Английский

Процитировано

96

Towards monitoring of antimicrobial resistance in the environment: For what reasons, how to implement it, and what are the data needs? DOI Creative Commons
Johan Bengtsson‐Palme, Anna Abramova, Thomas U. Berendonk

и другие.

Environment International, Год журнала: 2023, Номер 178, С. 108089 - 108089

Опубликована: Июль 6, 2023

Antimicrobial resistance (AMR) is a global threat to human and animal health well-being. To understand AMR dynamics, it important monitor resistant bacteria genes in all relevant settings. However, while monitoring of has been implemented clinical veterinary settings, comprehensive the environment almost completely lacking. Yet, environmental dimension critical for understanding dissemination routes selection microorganisms, as well risks related AMR. Here, we outline knowledge gaps that impede implementation monitoring. These include lack 'normal' background levels AMR, definition high-risk environments transmission, poor concentrations antibiotics other chemical agents promote selection. Furthermore, there methods detect are not already circulating among pathogens. We conclude these need be addressed before routine can on large scale. data bridging different sectors needed order fill gaps, which means some level national, regional surveillance must happen even without scientific questions answered. With possibilities opened up by rapidly advancing technologies, time gaps. Doing so will allow specific actions against development spread pathogens thereby safeguard wellbeing humans animals.

Язык: Английский

Процитировано

76

An Overview of the Recent Advances in Antimicrobial Resistance DOI Creative Commons
Manuela Oliveira, Wilson Antunes,

S. R. F. MOTA

и другие.

Microorganisms, Год журнала: 2024, Номер 12(9), С. 1920 - 1920

Опубликована: Сен. 21, 2024

Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by widespread prevalence constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, selective pressure) contribute to the emergence dissemination resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention control strategies—IPCs) emphasize importance responsible antimicrobial use surveillance. A One Health approach interconnectedness human, animal, environmental health) highlights necessity for interdisciplinary collaboration holistic in combating AMR. Advancements novel therapeutics alternative agents vaccines) offer promising avenues addressing challenges. Policy interventions at international national levels also promote ASPs aiming regulate use. Despite all observed progress, remains pressing concern, demanding sustained efforts address emerging threats sustainability. Future research must prioritize innovative approaches complex socioecological dynamics This manuscript resource researchers, policymakers, healthcare professionals seeking navigate develop effective mitigation.

Язык: Английский

Процитировано

34

Monitoring antibiotic resistance genes in wastewater environments: The challenges of filling a gap in the One-Health cycle DOI Creative Commons
Aleksandra Miłobędzka, Catarina Ferreira, Ivone Vaz‐Moreira

и другие.

Journal of Hazardous Materials, Год журнала: 2021, Номер 424, С. 127407 - 127407

Опубликована: Окт. 4, 2021

Antibiotic resistance (AR) is a global problem requiring international cooperation and coordinated action. Global monitoring must rely on methods available comparable across nations to quantify AR occurrence identify sources reservoirs, as well paths of dissemination. Numerous analytical tools that are gaining relevance in microbiology, have the potential be applied research. This review summarizes state art methods, considering distinct needs, objectives resources. Based overview approaches used or can adapted monitor AR, it discussed establish reliable useful schemes implemented contexts. discussion places environmental within One-Health approach, where two types risk, dissemination compartments, transmission humans, considered. The plethora methodological variable features monitored sites challenge capacity scientific community policy makers reach common understanding. However, dialogue between different production action-oriented data priority. aims warm up this discussion.

Язык: Английский

Процитировано

103

Seizing the moment: now is the time for integrated global surveillance of antimicrobial resistance in wastewater environments DOI Creative Commons
Amy Pruden, Peter J. Vikesland, Benjamin C. Davis

и другие.

Current Opinion in Microbiology, Год журнала: 2021, Номер 64, С. 91 - 99

Опубликована: Окт. 14, 2021

Язык: Английский

Процитировано

101

Higher abundance of core antimicrobial resistant genes in effluent from wastewater treatment plants DOI
Shahbaz Raza, Hanseob Shin, Hor‐Gil Hur

и другие.

Water Research, Год журнала: 2021, Номер 208, С. 117882 - 117882

Опубликована: Ноя. 19, 2021

Язык: Английский

Процитировано

98