BMJ Global Health,
Год журнала:
2025,
Номер
10(2), С. e016870 - e016870
Опубликована: Фев. 1, 2025
Epidemic
intelligence
efforts
aim
to
predict,
timely
detect
and
assess
(re-)emerging
pathogens,
guide
evaluate
infectious
disease
prevention
or
control.
We
emphasise
the
underused
potential
of
integrating
monitoring
risks
related
exposure,
death,
particularly
in
settings
where
limited
diagnostic
capacity
access
healthcare
hamper
prevention/control
measures.
Monitoring
One
Health
exposures,
human
behaviour,
immunity,
comorbidities,
uptake
control
measures
pathogen
characteristics
can
complement
facility-based
surveillance
generating
signals
imminent
ongoing
outbreaks,
targeting
preventive/control
interventions
epidemic
preparedness
high-risk
areas
subpopulations.
Low-cost
risk
data
sources
include
electronic
medical
records,
existing
household/patient/environmental
surveys,
Demographic
Surveillance
Systems,
medicine
distribution
programmatic
data.
Public
health
authorities
need
identify
prioritise
that
effectively
fill
gaps
not
accurately
answer,
determine
indicators
generate
from
data,
ensure
availability,
regular
analysis
dissemination.
Environment International,
Год журнала:
2020,
Номер
139, С. 105689 - 105689
Опубликована: Апрель 4, 2020
Infectious
diseases
are
acknowledged
as
one
of
the
most
critical
threats
to
global
public
health
today.
Climate
change,
unprecedented
population
growth
with
accelerated
rates
antimicrobial
resistance,
have
resulted
in
both
emergence
novel
pathogenic
organisms
and
re-emergence
infections
that
were
once
controlled.
The
consequences
led
an
increased
vulnerability
infectious
globally.
ability
rapidly
monitor
spread
is
key
for
prevention,
intervention
control,
however
several
limitations
exist
current
surveillance
systems
capacity
cope
rapid
environmental
changes.
Wastewater-Based
Epidemiology
(WBE)
a
new
epidemiology
tool
has
potential
act
complementary
approach
disease
early
warning
system
outbreaks.
WBE
postulates
through
analysis
pooled
wastewater,
resistance
spread,
outbreak
community
level
can
be
monitored
comprehensively
real-time.
This
manuscript
provides
overview
status,
well
it
introduces
its
recent
advancements.
It
also
recommendations
further
development
required
application
effective
surveillance.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Дек. 1, 2022
Abstract
Antimicrobial
resistance
(AMR)
is
a
major
threat
to
global
health.
Understanding
the
emergence,
evolution,
and
transmission
of
individual
antibiotic
genes
(ARGs)
essential
develop
sustainable
strategies
combatting
this
threat.
Here,
we
use
metagenomic
sequencing
analyse
ARGs
in
757
sewage
samples
from
243
cities
101
countries,
collected
2016
2019.
We
find
regional
patterns
resistomes,
these
differ
between
subsets
corresponding
drug
classes
are
partly
driven
by
taxonomic
variation.
The
genetic
environments
49
common
highly
diverse,
with
most
carried
multiple
distinct
genomic
contexts
globally
sometimes
on
plasmids.
Analysis
flanking
sequence
revealed
ARG-specific
dispersal
limitation
transmission.
Our
data
furthermore
suggest
certain
geographies
more
prone
events
should
receive
additional
attention.
Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Дек. 15, 2022
Infectious
diseases
caused
by
antibiotic-resistant
bacterial
(ARB)
pathogens
are
a
serious
threat
to
human
and
animal
health.
The
active
surveillance
of
ARB
using
an
integrated
one-health
approach
can
help
reduce
the
emergence
spread
ARB,
associated
economic
impact,
guide
antimicrobial
stewardship
programs.
Wastewater
(WWS)
provides
composite
samples
for
total
population,
with
easy
access
mixed
community
microbiome.
This
concept
is
emerging
rapidly,
but
clinical
utility,
sensitivity,
uniformity
WWS
remain
poorly
understood
especially
in
relation
evidence
sewershed
communities.
Here,
we
systematically
searched
literature
identify
studies
that
have
compared
findings
from
antibiotic
resistance
genes
(ARG)
parallel,
thereby
evaluating
how
likely
ARG
relate
cases
Initially,
2,235
articles
were
obtained
primary
search
keywords,
1,219
remained
after
de-duplication.
Among
these,
35
fulfilled
criteria,
additional
13
relevant
included
searching
references
literature.
48
papers,
34
used
culture-based
method,
followed
11
metagenomics,
three
PCR-based
methods.
A
28
out
conducted
at
single
level,
eight
involved
several
countries,
seven
national
or
regional
scales,
five
hospital
levels.
Our
review
revealed
performance
has
been
evaluated
more
frequently
Escherichia
coli,
Enterococcus
spp.,
other
members
family
Enterobacteriaceae
,
not
uniformly
tested
all
pathogens.
Many
wastewater-based
comparing
evaluate
public
health
risk
ARB.
Indeed,
relating
straightforward,
as
source
wastewater
cannot
be
only
symptomatic
individuals
also
asymptomatic
carriers
well
sources.
Further,
varying
fates
each
species
within
sewerage
make
aim
connecting
complicated.
Therefore,
future
many
AMR
their
one
process
simpler
interpretation
results
easier.
Environment International,
Год журнала:
2023,
Номер
178, С. 108089 - 108089
Опубликована: Июль 6, 2023
Antimicrobial
resistance
(AMR)
is
a
global
threat
to
human
and
animal
health
well-being.
To
understand
AMR
dynamics,
it
important
monitor
resistant
bacteria
genes
in
all
relevant
settings.
However,
while
monitoring
of
has
been
implemented
clinical
veterinary
settings,
comprehensive
the
environment
almost
completely
lacking.
Yet,
environmental
dimension
critical
for
understanding
dissemination
routes
selection
microorganisms,
as
well
risks
related
AMR.
Here,
we
outline
knowledge
gaps
that
impede
implementation
monitoring.
These
include
lack
'normal'
background
levels
AMR,
definition
high-risk
environments
transmission,
poor
concentrations
antibiotics
other
chemical
agents
promote
selection.
Furthermore,
there
methods
detect
are
not
already
circulating
among
pathogens.
We
conclude
these
need
be
addressed
before
routine
can
on
large
scale.
data
bridging
different
sectors
needed
order
fill
gaps,
which
means
some
level
national,
regional
surveillance
must
happen
even
without
scientific
questions
answered.
With
possibilities
opened
up
by
rapidly
advancing
technologies,
time
gaps.
Doing
so
will
allow
specific
actions
against
development
spread
pathogens
thereby
safeguard
wellbeing
humans
animals.
Microorganisms,
Год журнала:
2024,
Номер
12(9), С. 1920 - 1920
Опубликована: Сен. 21, 2024
Antimicrobial
resistance
(AMR),
frequently
considered
a
major
global
public
health
threat,
requires
comprehensive
understanding
of
its
emergence,
mechanisms,
advances,
and
implications.
AMR’s
epidemiological
landscape
is
characterized
by
widespread
prevalence
constantly
evolving
patterns,
with
multidrug-resistant
organisms
(MDROs)
creating
new
challenges
every
day.
The
most
common
mechanisms
underlying
AMR
(i.e.,
genetic
mutations,
horizontal
gene
transfer,
selective
pressure)
contribute
to
the
emergence
dissemination
resistant
strains.
Therefore,
mitigation
strategies
(e.g.,
antibiotic
stewardship
programs—ASPs—and
infection
prevention
control
strategies—IPCs)
emphasize
importance
responsible
antimicrobial
use
surveillance.
A
One
Health
approach
interconnectedness
human,
animal,
environmental
health)
highlights
necessity
for
interdisciplinary
collaboration
holistic
in
combating
AMR.
Advancements
novel
therapeutics
alternative
agents
vaccines)
offer
promising
avenues
addressing
challenges.
Policy
interventions
at
international
national
levels
also
promote
ASPs
aiming
regulate
use.
Despite
all
observed
progress,
remains
pressing
concern,
demanding
sustained
efforts
address
emerging
threats
sustainability.
Future
research
must
prioritize
innovative
approaches
complex
socioecological
dynamics
This
manuscript
resource
researchers,
policymakers,
healthcare
professionals
seeking
navigate
develop
effective
mitigation.
Journal of Hazardous Materials,
Год журнала:
2021,
Номер
424, С. 127407 - 127407
Опубликована: Окт. 4, 2021
Antibiotic
resistance
(AR)
is
a
global
problem
requiring
international
cooperation
and
coordinated
action.
Global
monitoring
must
rely
on
methods
available
comparable
across
nations
to
quantify
AR
occurrence
identify
sources
reservoirs,
as
well
paths
of
dissemination.
Numerous
analytical
tools
that
are
gaining
relevance
in
microbiology,
have
the
potential
be
applied
research.
This
review
summarizes
state
art
methods,
considering
distinct
needs,
objectives
resources.
Based
overview
approaches
used
or
can
adapted
monitor
AR,
it
discussed
establish
reliable
useful
schemes
implemented
contexts.
discussion
places
environmental
within
One-Health
approach,
where
two
types
risk,
dissemination
compartments,
transmission
humans,
considered.
The
plethora
methodological
variable
features
monitored
sites
challenge
capacity
scientific
community
policy
makers
reach
common
understanding.
However,
dialogue
between
different
production
action-oriented
data
priority.
aims
warm
up
this
discussion.
