Searching for the Metaverse: Neuroscience of Physical and Digital Communities DOI Creative Commons
Giuseppe Riva, Brenda K. Wiederhold, Fabrizia Mantovani

и другие.

Cyberpsychology Behavior and Social Networking, Год журнала: 2023, Номер 27(1), С. 9 - 18

Опубликована: Апрель 14, 2023

What distinguishes real-world communities from their online counterparts? Social and cognitive neuroscience research on social networks collective intentionality will be used in the article to answer this question. Physical are born places. And places engage "we-mode" neurobiological processes as behavioral synchrony, shared attention, deliberate attunement, interbrain synchronization, so on, which create coherent of very different individuals who supported by a "wisdom crowd." Digital technologies remove physical boundaries, giving people more freedom choose activities groups. At same time, however, lack co-presence community members significantly reduces possibility activating motivation. Because this, unlike that allow interaction between varied origins stories, digital always made up have interests knowledge (communities practice). This new situation disrupts crowd," making radical less accurate (polarization effect), allowing influential users wield disproportionate influence over group's beliefs, producing inequalities distribution capital. However, emergent technology-the Metaverse-has potential reverse trend. Several studies revealed virtual augmented reality-the major underlying Metaverse-can environments. If many flaws technology fixed, it might encourage meaningful constructive interactions communities.

Язык: Английский

Brain circuits for pain and its treatment DOI
Nicole Mercer Lindsay, Chong Chen, Gadi Gilam

и другие.

Science Translational Medicine, Год журнала: 2021, Номер 13(619)

Опубликована: Ноя. 10, 2021

Understanding the organization of brain’s pain circuits is critical for developing effective treatments patients suffering from chronic pain.

Язык: Английский

Процитировано

149

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications DOI Creative Commons

Chen-Chen Jiang,

Lishan Lin,

Sen Long

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июль 11, 2022

Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental which has strong genetic basis. Despite the rapidly rising incidence of autism, little known about its aetiology, risk factors, disease progression. There are currently neither validated biomarkers for diagnostic screening nor specific medication autism. Over last two decades, there have been remarkable advances in genetics, with hundreds genes identified as being associated high The convergence neuroscience methods becoming more widely recognized significance elucidating pathological mechanisms Efforts devoted to exploring behavioural functions, key potential treatments Here, we highlight this review, emerging evidence shows that signal transduction molecular events involved processes such transcription, translation, synaptic transmission, epigenetics immunoinflammatory responses. This involvement important implications discovery precise targets Moreover, review recent insights into clinical autism from molecular, cellular, neural circuit, neurobehavioural aspects. Finally, challenges future perspectives discussed regard novel strategies predicated on biological features

Язык: Английский

Процитировано

141

Innovations and advances in modelling and measuring pain in animals DOI
Katelyn E. Sadler, Jeffrey S. Mogil, Cheryl L. Stucky

и другие.

Nature reviews. Neuroscience, Год журнала: 2021, Номер 23(2), С. 70 - 85

Опубликована: Ноя. 26, 2021

Язык: Английский

Процитировано

123

Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain DOI Creative Commons
Mingming Zhang,

Anqi Geng,

Kun Chen

и другие.

Neuron, Год журнала: 2022, Номер 110(12), С. 1993 - 2008.e6

Опубликована: Апрель 19, 2022

Язык: Английский

Процитировано

106

Emotional contagion and prosocial behavior in rodents DOI Creative Commons
Christian Keysers, Ewelina Knapska, Marta A. Moita

и другие.

Trends in Cognitive Sciences, Год журнала: 2022, Номер 26(8), С. 688 - 706

Опубликована: Июнь 3, 2022

Empathy is critical to adjusting our behavior the state of others. The past decade dramatically deepened understanding biological origin this capacity. We now understand that rodents robustly show emotional contagion for distress others via neural structures homologous those involved in human empathy. Their propensity approach strengthens effect. Although can also learn favor behaviors benefit overlapping with contagion, they do so less reliably and more selectively. Together, suggests evolution selected mechanisms prepare animals dangers by using as sentinels. Such shared emotions additionally can, under certain circumstances, promote prosocial behavior.

Язык: Английский

Процитировано

90

Sound induces analgesia through corticothalamic circuits DOI Open Access
Wenjie Zhou, Chonghuan Ye, Haitao Wang

и другие.

Science, Год журнала: 2022, Номер 377(6602), С. 198 - 204

Опубликована: Июль 7, 2022

Sound-including music and noise-can relieve pain in humans, but the underlying neural mechanisms remain unknown. We discovered that analgesic effects of sound depended on a low (5-decibel) signal-to-noise ratio (SNR) relative to ambient noise mice. Viral tracing, microendoscopic calcium imaging, multitetrode recordings freely moving mice showed low-SNR sounds inhibited glutamatergic inputs from auditory cortex (ACxGlu) thalamic posterior (PO) ventral (VP) nuclei. Optogenetic or chemogenetic inhibition ACxGlu→PO ACxGlu→VP circuits mimicked sound-induced analgesia inflamed hindpaws forepaws, respectively. Artificial activation these two abolished analgesia. Our study reveals corticothalamic sound-promoted by deciphering role system processing.

Язык: Английский

Процитировано

75

Hippocampal-amygdala memory circuits govern experience-dependent observational fear DOI Creative Commons
Joseph I. Terranova, Jun Yokose, Hisayuki Osanai

и другие.

Neuron, Год журнала: 2022, Номер 110(8), С. 1416 - 1431.e13

Опубликована: Фев. 8, 2022

The empathic ability to vicariously experience the other's fearful situation, a process called observational fear (OF), is critical survive in nature and function society. OF can be facilitated by both prior similar observer social familiarity with demonstrator. However, neural circuit mechanisms of experience-dependent (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits mice without involving anterior cingulate cortex, considered center OF, mediate Exp OF. Dorsal HPC neurons generate memory engram cells BLA encoding experiences, which are essential for On other hand, ventral respond familiar demonstrator's aversive situation during reactivates elicit Our study provides new insights into engram-dependent perception-action coupling underlies behaviors like

Язык: Английский

Процитировано

73

Social circuits and their dysfunction in autism spectrum disorder DOI Creative Commons
Masaaki Sato, Nobuhiro Nakai,

Shuhei Fujima

и другие.

Molecular Psychiatry, Год журнала: 2023, Номер 28(8), С. 3194 - 3206

Опубликована: Авг. 1, 2023

Social behaviors, how individuals act cooperatively and competitively with conspecifics, are widely seen across species. Rodents display various social many different behavioral paradigms have been used for investigating their neural circuit bases. behavior is highly vulnerable to brain network dysfunction caused by neurological neuropsychiatric conditions such as autism spectrum disorders (ASDs). Studying mouse models of ASD provides a promising avenue toward elucidating mechanisms abnormal potential therapeutic targets treatment. In this review, we outline recent progress key findings on underlying behavior, particular emphasis rodent studies that monitor manipulate the activity specific circuits using modern systems neuroscience approaches. mediated distributed brain-wide among major cortical (e.g., medial prefrontal cortex (mPFC), anterior cingulate cortex, insular (IC)) subcortical nucleus accumbens, basolateral amygdala (BLA), ventral tegmental area) structures, influenced multiple neuromodulatory oxytocin, dopamine, serotonin). We particularly draw special attention IC unique area mediates multisensory integration, encoding ongoing interaction, decision-making, emotion, empathy. Additionally, synthesis demonstrates dysfunctions in mPFC-BLA circuitry neuromodulation prominent. Pharmacological rescues local or systemic oral) administration drugs provided valuable clues developing new agents ASD. Future efforts technological advances will push forward next frontiers field, elucidation inter-brain dynamics during real virtual interactions, establishment circuit-based therapy affecting functions.

Язык: Английский

Процитировано

58

An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences DOI
Qian Song, Anqi Wei, Hua‐Dong Xu

и другие.

Nature Neuroscience, Год журнала: 2024, Номер 27(2), С. 272 - 285

Опубликована: Янв. 3, 2024

Язык: Английский

Процитировано

40

Cortical regulation of helping behaviour towards others in pain DOI
Mingmin Zhang, Ye Wu,

Mengping Jiang

и другие.

Nature, Год журнала: 2024, Номер 626(7997), С. 136 - 144

Опубликована: Янв. 24, 2024

Язык: Английский

Процитировано

32