Nature Reviews Endocrinology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 24, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Март 1, 2024
Abstract Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, inflammation. Accumulating evidence has shown that implicated in diseases, such as cancers, cardiac diseases cardiovascular neurological disorders, kidney motor system metabolic disorders. Examining the upstream modulators co-activated partners identifying critical biological events modulated by downstream effectors contribute to presentation elaborate network PGC-1s. Furthermore, discussing correlation between well summarizing therapy targeting helps make individualized precise intervention methods. In this review, we summarize basic knowledge regarding molecular regulatory network, discuss physio-pathological roles human review application PGC-1s, diagnostic prognostic value several therapies pre-clinical studies, suggest directions for future investigations. This presents immense potential treatment hopefully facilitates promotion new therapeutic targets.
Язык: Английский
Процитировано
84
Journal of Pharmaceutical Analysis, Год журнала: 2023, Номер 13(4), С. 355 - 366
Опубликована: Янв. 7, 2023
Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is involved microbicidal activity. NE an important factor promoting inflammation, has bactericidal effects, and shortens inflammatory process. also regulates tumor growth by metastasis microenvironment remodeling. However, plays role killing tumors under certain conditions promotes other diseases such as pulmonary ventilation dysfunction. Additionally, it complex various physiological processes mediates several diseases. Sivelestat, specific inhibitor, strong potential for clinical application, particularly treatment coronavirus disease 2019 (COVID-19). This review discusses pathophysiological associated with applications sivelestat.
Язык: Английский
Процитировано
80
Foods, Год журнала: 2022, Номер 11(24), С. 3961 - 3961
Опубликована: Дек. 7, 2022
For thousands of years, edible insects have been used as food to alleviate hunger and improve malnutrition. Some also medicines because their therapeutic properties. This is not only due the high nutritional value insects, but more importantly, active substances from a variety biofunctional activities. In this paper, we described summarized composition discussed biological functions potential benefits for human health. A summary analysis findings each function confirms that develop functional foods are beneficial humans. addition, analyzed issues need be considered in application current status pharmaceutical applications. We concluded with discussion regulations related an outlook on future research applications insects. By analyzing state aim raise awareness use health thus promote better development.
Язык: Английский
Процитировано
77
Annual Review of Immunology, Год журнала: 2023, Номер 41(1), С. 229 - 254
Опубликована: Фев. 4, 2023
Type 2 immunity mediates protective responses to helminths and pathological allergens, but it also has broad roles in the maintenance of tissue integrity, including wound repair. cytokines are known promote fibrosis, an overzealous repair response, their contribution healthy is less well understood. This review discusses evidence that canonical type cytokines, IL-4 IL-13, integral process through two main pathways. First, essential for progression effective repair, IL-13 suppress initial inflammatory response injury. Second, these regulate how extracellular matrix modified, broken down, rebuilt and/or amplifies multiple aspects many pathways highly redundant can be induced by other signals. Therefore, exact IL-4Rα signaling remains difficult unravel.
Язык: Английский
Процитировано
76
Nature reviews. Immunology, Год журнала: 2022, Номер 23(4), С. 222 - 235
Опубликована: Окт. 3, 2022
Язык: Английский
Процитировано
73
Nature Immunology, Год журнала: 2023, Номер 24(7), С. 1173 - 1187
Опубликована: Июнь 8, 2023
Abstract Blood protein extravasation through a disrupted blood–brain barrier and innate immune activation are hallmarks of neurological diseases emerging therapeutic targets. However, how blood proteins polarize cells remains largely unknown. Here, we established an unbiased blood-innate immunity multiomic genetic loss-of-function pipeline to define the transcriptome global phosphoproteome blood-induced polarization its role in microglia neurotoxicity. induced widespread microglial transcriptional changes, including changes involving oxidative stress neurodegenerative genes. Comparative functional multiomics showed that induce distinct receptor-mediated programs macrophages, such as redox, type I interferon lymphocyte recruitment. Deletion coagulation factor fibrinogen reversed signatures. Genetic elimination fibrinogen-binding motif CD11b Alzheimer’s disease mice reduced lipid metabolism signatures were shared with autoimmune-driven neuroinflammation multiple sclerosis mice. Our data provide interactive resource for investigation immunology could support targeting by vascular signals.
Язык: Английский
Процитировано
72
Chemical Society Reviews, Год журнала: 2023, Номер 52(3), С. 1024 - 1067
Опубликована: Янв. 1, 2023
Schematic diagram of noncancerous disease-targeting AIEgens.
Язык: Английский
Процитировано
66
The Lancet Respiratory Medicine, Год журнала: 2023, Номер 12(4), С. 305 - 322
Опубликована: Дек. 21, 2023
Язык: Английский
Процитировано
63
Molecular Neurodegeneration, Год журнала: 2023, Номер 18(1)
Опубликована: Июнь 5, 2023
Abstract Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon has been identified a risk factor for Alzheimer’s disease. While role of chronic peripheral well characterized in context dementia and other conditions, less known about neurologic contribution acute inflammatory insults take place system. Herein, we define immune challenge form pathogen exposure (e.g., viral infection) or tissue damage surgery) causes large, yet time-limited, response. We provide overview clinical translational research examined connection between disease, focusing on three categories have received considerable attention recent years: infection, critical illness, surgery. Additionally, review neurobiological mechanisms which facilitate neural response to discuss potential blood–brain barrier components neuro-immune axis After highlighting knowledge gaps this area research, propose roadmap address methodological challenges, suboptimal study design, paucity transdisciplinary efforts thus far limited our understanding how pathogen- damage-mediated may contribute Finally, therapeutic approaches designed promote resolution be used following preserve brain health limit progression neurodegenerative pathology.
Язык: Английский
Процитировано
55
European Journal of Surgical Oncology, Год журнала: 2023, Номер 50(5), С. 107074 - 107074
Опубликована: Сен. 14, 2023
Cancer patients are at a high risk of malnutrition and disease-associated catabolic derangements. It is important to differentiate between 'simple' - voluntary or involuntary caloric restriction with protein-sparing ketogenic metabolic adaptation cachexia, characterized by the combination weight loss dysmetabolism, most prominently systemic inflammation. While both conditions result in sacrifice fat protein stores thus impact on treatment tolerance, complication rates survival, presence derangements especially dangerous straining multiple organ functions. To avoid underdiagnosing undertreating malnutrition, all cancer should be routinely screened for nutritional risk. At-risk require comprehensive assessment contributing treatable causes and, if available, multi-professional efforts improve food intake, support anabolism, alleviate distress antagonize pro-inflammatory processes. In curative settings, anabolic accompany even precede anticancer treatments. Prehabilitation before major surgery, has been studied extensively, including muscle training as well and/or psychological support. Recent meta-analyses report consistent benefit functional capacity possible improvement postoperative complications length hospital stay. palliative prevailing careful individual constellation disturbed functions an empathic evaluation benefits risks interventions. This special relevance expected survival less than few months. Due complex interactions mechanical, factors, teams involved.
Язык: Английский
Процитировано
47