Bacterial cGAS senses a viral RNA to initiate immunity DOI Creative Commons
Dalton V. Banh, Cameron G. Roberts, Adrián Morales-Amador

и другие.

Nature, Год журнала: 2023, Номер 623(7989), С. 1001 - 1008

Опубликована: Ноя. 15, 2023

Cyclic oligonucleotide-based antiphage signalling systems (CBASS) protect prokaryotes from viral (phage) attack through the production of cyclic oligonucleotides, which activate effector proteins that trigger death infected host1,2. How bacterial cyclases recognize phage infection is not known. Here we show staphylococcal phages produce a structured RNA transcribed terminase subunit genes, termed CBASS-activating bacteriophage (cabRNA), binds to positively charged surface CdnE03 cyclase and promotes synthesis dinucleotide cGAMP CBASS immune response. Phages escape defence harbour mutations lead generation longer form cabRNA cannot CdnE03. As mammalian OAS1 also double-stranded during interferon response, our results reveal conserved mechanism for activation innate antiviral pathways.

Язык: Английский

CARD domains mediate anti-phage defence in bacterial gasdermin systems DOI
Tanita Wein, Adi Millman, Kathrin Lange

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Язык: Английский

Процитировано

2
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins DOI Creative Commons
Shai Zilberzwige‐Tal, Han Altae-Tran, Soumya Kannan

и другие.

Cell, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Structure, biochemical function, and signaling mechanism of plant NLRs DOI Creative Commons
Jizong Wang, Wen Song, Jijie Chai

и другие.

Molecular Plant, Год журнала: 2022, Номер 16(1), С. 75 - 95

Опубликована: Ноя. 22, 2022

To counter pathogen invasion, plants have evolved a large number of immune receptors, including membrane-resident pattern recognition receptors (PRRs) and intracellular nucleotide-binding leucine-rich repeat (NLRs). Our knowledge about PRR NLR signaling mechanisms has expanded significantly over the past few years. Plant NLRs form multi-protein complexes called resistosomes in response to effectors, mediated by converges on Ca2+-permeable channels. channels important for also been identified. These findings highlight crucial role Ca2+ triggering plant signaling. In this review, we first discuss structural biochemical non-canonical then summarize our immune-related their roles We potential intricate interaction between

Язык: Английский

Процитировано

50
Resurrection of plant disease resistance proteins via helper NLR bioengineering DOI Creative Commons
Mauricio P. Contreras, Hsuan Pai, Muniyandi Selvaraj

и другие.

Science Advances, Год журнала: 2023, Номер 9(18)

Опубликована: Май 3, 2023

Parasites counteract host immunity by suppressing helper nucleotide binding and leucine-rich repeat (NLR) proteins that function as central nodes in immune receptor networks. Understanding the mechanisms of immunosuppression can lead to strategies for bioengineering disease resistance. Here, we show a cyst nematode virulence effector binds inhibits oligomerization NLR protein NRC2 physically preventing intramolecular rearrangements required activation. An amino acid polymorphism at interface between inhibitor is sufficient this evade suppression, thereby restoring activity multiple resistance genes. This points potential strategy resurrecting crop genomes.

Язык: Английский

Процитировано

39
Bacterial cGAS senses a viral RNA to initiate immunity DOI Creative Commons
Dalton V. Banh, Cameron G. Roberts, Adrián Morales-Amador

и другие.

Nature, Год журнала: 2023, Номер 623(7989), С. 1001 - 1008

Опубликована: Ноя. 15, 2023

Cyclic oligonucleotide-based antiphage signalling systems (CBASS) protect prokaryotes from viral (phage) attack through the production of cyclic oligonucleotides, which activate effector proteins that trigger death infected host1,2. How bacterial cyclases recognize phage infection is not known. Here we show staphylococcal phages produce a structured RNA transcribed terminase subunit genes, termed CBASS-activating bacteriophage (cabRNA), binds to positively charged surface CdnE03 cyclase and promotes synthesis dinucleotide cGAMP CBASS immune response. Phages escape defence harbour mutations lead generation longer form cabRNA cannot CdnE03. As mammalian OAS1 also double-stranded during interferon response, our results reveal conserved mechanism for activation innate antiviral pathways.

Язык: Английский

Процитировано

30