Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Фев. 26, 2025
Abstract
Colorectal
cancer
(CRC)
is
the
third
most
common
malignancy
globally
and
second
leading
cause
of
cancer-related
mortality.
Its
development
a
multifactorial
multistage
process
influenced
by
dynamic
interplay
between
gut
microbiota,
environmental
factors,
fatty
acid
metabolism.
Dysbiosis
intestinal
microbiota
abnormalities
in
microbiota-associated
metabolites
have
been
implicated
colorectal
carcinogenesis,
highlighting
pivotal
role
microbial
metabolic
interactions.
Fatty
metabolism
serves
as
critical
nexus
linking
dietary
patterns
with
activity,
significantly
impacting
health.
In
CRC
patients,
reduced
levels
short-chain
acids
(SCFAs)
SCFA-producing
bacteria
consistently
observed.
Supplementation
probiotics
has
demonstrated
tumor-suppressive
effects,
while
therapeutic
strategies
aimed
at
modulating
SCFA
shown
potential
enhancing
efficacy
radiation
therapy
immunotherapy
both
preclinical
clinical
settings.
This
review
explores
intricate
relationship
metabolism,
CRC,
offering
insights
into
underlying
mechanisms
their
translational
applications.
Understanding
this
could
pave
way
for
novel
diagnostic,
therapeutic,
preventive
management
CRC.
Science,
Год журнала:
2022,
Номер
377(6612), С. 1328 - 1332
Опубликована: Сен. 15, 2022
The
gut
microbiomes
of
human
populations
worldwide
have
many
core
microbial
species
in
common.
However,
within
a
species,
some
strains
can
show
remarkable
population
specificity.
question
is
whether
such
specificity
arises
from
shared
evolutionary
history
(codiversification)
between
humans
and
their
microbes.
To
test
for
codiversification
host
microbiota,
we
analyzed
paired
metagenomes
genomes
1225
individuals
Europe,
Asia,
Africa,
including
mothers
children.
Between
countries,
parallel
was
evident
Moreover,
displaying
the
strongest
independently
evolved
traits
characteristic
dependency,
reduced
oxygen
temperature
sensitivity.
These
findings
all
point
to
importance
understanding
potential
role
population-specific
microbiome-mediated
disease
phenotypes.
Cell,
Год журнала:
2023,
Номер
186(14), С. 3111 - 3124.e13
Опубликована: Июнь 21, 2023
The
gut
microbiome
modulates
immune
and
metabolic
health.
Human
data
are
biased
toward
industrialized
populations,
limiting
our
understanding
of
non-industrialized
microbiomes.
Here,
we
performed
ultra-deep
metagenomic
sequencing
on
351
fecal
samples
from
the
Hadza
hunter-gatherers
Tanzania
comparative
populations
in
Nepal
California.
We
recovered
91,662
genomes
bacteria,
archaea,
bacteriophages,
eukaryotes,
44%
which
absent
existing
unified
datasets.
identified
124
gut-resident
species
vanishing
highlighted
distinct
aspects
related
to
situ
replication
rates,
signatures
selection,
strain
sharing.
Industrialized
microbes
were
found
be
enriched
genes
associated
with
oxidative
stress,
possibly
a
result
adaptation
inflammatory
processes.
This
unparalleled
view
provides
valuable
resource,
expands
capable
colonizing
human
gut,
clarifies
extensive
perturbation
induced
by
lifestyle.
Foods,
Год журнала:
2023,
Номер
12(11), С. 2140 - 2140
Опубликована: Май 25, 2023
Various
fields
have
been
identified
in
the
"omics"
era,
such
as
genomics,
proteomics,
transcriptomics,
metabolomics,
phenomics,
and
metagenomics.
Among
these,
metagenomics
has
enabled
a
significant
increase
discoveries
related
to
microbial
world.
Newly
discovered
microbiomes
different
ecologies
provide
meaningful
information
on
diversity
functions
of
microorganisms
Earth.
Therefore,
results
metagenomic
studies
new
microbe-based
applications
human
health,
agriculture,
food
industry,
among
others.
This
review
summarizes
fundamental
procedures
recent
advances
bioinformatic
tools.
It
also
explores
up-to-date
study,
plant
research,
environmental
sciences,
other
fields.
Finally,
is
powerful
tool
for
studying
world,
it
still
numerous
that
are
currently
hidden
awaiting
discovery.
this
discusses
future
perspectives
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Май 14, 2024
The
gut
microbiota
plays
a
critical
role
in
the
progression
of
human
diseases,
especially
cancer.
In
recent
decades,
there
has
been
accumulating
evidence
connections
between
and
cancer
immunotherapy.
Therefore,
understanding
functional
regulating
immune
responses
to
immunotherapy
is
crucial
for
developing
precision
medicine.
this
review,
we
extract
insights
from
state-of-the-art
research
decipher
complicated
crosstalk
among
microbiota,
systemic
system,
context
Additionally,
as
can
account
immune-related
adverse
events,
discuss
potential
interventions
minimize
these
effects
clinical
application
five
microbiota-targeted
strategies
that
precisely
increase
efficacy
Finally,
holds
promising
target
immunotherapeutics,
summarize
current
challenges
provide
general
outlook
on
future
directions
field.
Abstract
Gut
microbiota
is
essential
for
maintaining
local
and
systemic
immune
homeostasis
in
the
presence
of
bacterial
challenges.
It
has
been
demonstrated
that
play
contrasting
roles
cancer
development
as
well
anticancer
immunity.
Cancer
immunotherapy,
a
novel
therapy
relies
on
stimulation
host
immunity,
suffered
from
low
responding
rate
incidence
severe
immune‐related
adverse
events
(irAEs).
Previous
studies
have
diversity
composition
gut
were
associated
with
heterogeneity
therapeutic
effects.
Therefore,
alteration
taxa
can
lead
to
improved
clinical
outcomes
immunotherapy.
In
this
review,
we
determine
whether
or
microbiota‐derived
metabolites
are
linked
responses
immunotherapy
irAEs.
Moreover,
discuss
various
approaches
improve
efficacy
reduce
toxicities
by
modulating
composition.
Many
species,
including
humans,
host
communities
of
symbiotic
microbes.
There
is
a
vast
literature
on
the
ways
these
microbiomes
affect
hosts,
but
here
we
argue
for
an
increased
focus
how
hosts
their
microbiomes.
Hosts
exert
control
over
symbionts
through
diverse
mechanisms,
immunity,
barrier
function,
physiological
homeostasis,
and
transit.
These
mechanisms
enable
to
shape
ecology
evolution
generate
natural
selection
microbial
traits
that
benefit
host.
Our
result
from
perpetual
tension
between
symbiont
evolution,
can
leverage
host's
evolved
abilities
regulate
microbiota
prevent
treat
disease.
The
study
will
be
central
our
ability
both
understand
manipulate
microbiotas
better
health.
