European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 199, С. 114303 - 114303
Опубликована: Апрель 23, 2024
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 626 - 626
Опубликована: Май 7, 2024
In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer the type of microneedles used (proposing needles saw), use certain enhancers such as essential oils (which, besides amplifier action, also have intrinsic actions health), associations active substances with synergistic well copolymeric membranes, cemented directly tooth. We propose a review principles release at level mucosa main systems pathology. Controlled failure applicable pathology include following: fast dissolving films, mucoadhesive tablets, hydrogels, intraoral composite wafers, smart drugs. The novelty elements brought paper possibilities optimizing localized delivery system osteoarthritis temporomandibular joint, neuropathic pain, cancer, periodontitis, pericoronitis, maintaining health. would like mention possibility incorporating natural products into controlled paying special attention oils.
Язык: Английский
Процитировано
20
Carbohydrate Polymers, Год журнала: 2024, Номер 345, С. 122574 - 122574
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
15
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(3), С. 1682 - 1693
Опубликована: Фев. 9, 2024
Microneedle-based drug delivery offers an attractive and minimally invasive administration route to deliver therapeutic agents through the skin by bypassing stratum corneum, main barrier. Recently, hydrogel-based microneedles have gained prominence for their exceptional ability precisely control release of cargo. In this study, we investigated feasibility fabricating from triblock amphiphiles with linear poly(ethylene glycol) (PEG) as hydrophilic middle block two dendritic side-blocks enzyme-cleavable hydrophobic end-groups. Due poor formation brittleness made neat amphiphile, added a sodium alginate base layer tested different polymeric excipients enhance mechanical strength microneedles. Following optimization, based on were successfully fabricated exhibited favorable insertion efficiency low height reduction percentage when in Parafilm skin-simulant model. When against static forces ranging 50 1000 g (4.9–98 mN/needle), showed adequate no fractures or broken segments. buffer solution, solid swelled into hydrogel within about 30 s, followed rapid disintegration small particles. These particles could undergo slow enzymatic degradation soluble polymers. vitro study dexamethasone (DEX), steroid model drug, first-order release, 90% released 6 days. Eventually, DEX-loaded MNs subjected test using chicken full penetration. This demonstrates programming hydrogel-forming several mesophase transitions potential application system self-administration, increased patient compliance, improved efficacy, sustained release.
Язык: Английский
Процитировано
12
ACS Sensors, Год журнала: 2024, Номер 9(2), С. 535 - 542
Опубликована: Фев. 13, 2024
Continuous health monitoring aims to reduce hospitalization and the need for constant supervision of patients. For an outpatient device be effective, it must meet certain criteria: should demand minimal patient involvement, reliable, connected, remain stable with infrequent replacements, cost-efficient, compatible humans, ultimately self-powered. Microneedle (MN) technology, designed transdermal biosensing, offers a promising solution meeting wide range these demands in field continuous monitoring. A variety MN platforms have been developed facilitate this crucial function. Our focus Perspective is on significant challenges linked MN-based biosensors. These include ensuring skin compatibility, effective integration biorecognition elements into systems, durability concerns sensors enabling extended periods Tackling hurdles could pave way more reliable solutions future.
Язык: Английский
Процитировано
8
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 208, С. 115292 - 115292
Опубликована: Март 24, 2024
Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious and saves millions lives every year. Vaccine design development remains critical involves many aspects, including choice platform, antigen, adjuvant, route administration. Topical vaccination, defined herein as introduction a vaccine any three layers human skin, has attracted interest recent years an alternative vaccination approach conventional intramuscular administration because its potential be needle-free induce superior immune response against pathogens. In this review, we describe progress developing topical vaccines, highlight delivery technologies for discuss factors that might impact efficacy, provide overview current clinical landscape vaccines.
Язык: Английский
Процитировано
8
Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 209 - 209
Опубликована: Фев. 4, 2025
This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was in various databases published last 10 years, with strict inclusion and exclusion criteria. Of 490 found, 40 were considered relevant. Acne vulgaris is common dermatological disorder characterised inflammation sebaceous glands, often resulting development pimples, cysts, scarring. Conventional treatments, including antibiotics topical retinoids, frequently demonstrate limitations such as side effects, resistance, insufficient absorption. Recent advancements nanotechnology have enabled creation innovative drug-delivery that enhance effectiveness reduce adverse effects anti-acne medications. Polyphenols flavonoids, bioactive compounds notable anti-inflammatory, antioxidant, antibacterial properties, are recognised their therapeutic acne treatment. However, practical application hindered solubility, stability, bioavailability. incorporation these into nanoparticle-based delivery has shown promise resolving challenges. Various nanoparticle platforms, lipid-based nanoparticles, polymeric solid lipid evaluated ability improve controlled release, targeted polyphenols flavonoids skin. advent polyphenol flavonoid-loaded nanoparticles marks new therapy era.
Язык: Английский
Процитировано
1
Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(12), С. 3512 - 3548
Опубликована: Май 9, 2024
Язык: Английский
Процитировано
6
Small Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug while complemented with noninvasiveness patient compliance. Currently, the topical application of antimicrobials restricts drugs to critical areas wound bed, largely due barriers posed by necrotic tissue, scab formation, bacterial biofilms, which severely diminish bioavailability therapeutics. MNs enabled efficient targeted overcome many chronic challenges. Over past decade, significant progress has been made develop unique properties tailored for vaccines, anticancer, antimicrobials. As ongoing research continues refine MN design, material properties, formulations, potential revolutionizing efficacy, experience, therapeutic outcomes remains at forefront scientific research. In this review, insights are provided into latest progress, current developments, diverse applications delivery. Herein, translational is highlighted perspective on challenges associated clinical translation provided. Furthermore, review aids in identifying gaps empowering contributing future implementation cutting‐edge systems effectively tackle resistance.
Язык: Английский
Процитировано
5
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 90, С. 105163 - 105163
Опубликована: Ноя. 14, 2023
Язык: Английский
Процитировано
11
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105627 - 105627
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
4