Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
All-aqueous
embedded
3D
printing,
which
involves
extruding
inks
in
an
aqueous
bath,
has
emerged
as
a
transformative
platform
for
the
freeform
fabrication
of
constructs
with
precise
control.
The
use
supporting
bath
not
only
enables
printing
arbitrarily
designed
but
also
broadens
ink
selection
various
soft
matters,
advancing
wide
application
this
technology.
This
review
focuses
on
recent
progress
preparation
using
all-aqueous
printing.
It
begins
by
discussing
significance
ultralow
interfacial
tension
all-liquid
and
highlights
fundamental
concepts
properties
system.
then
introduces
advances
clarifies
key
factors
affecting
stability
shape
fidelity,
aiming
to
guide
expansion
assessment
emerging
systems
used
representative
applications.
Furthermore,
it
proposes
potential
scope
applications
technology,
including
vitro
models,
cytomimetic
microreactors,
ionic
electronics.
Finally,
discusses
challenges
facing
current
offers
future
perspectives
possible
improvements
developments.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Engineered
living
systems
(ELSs)
represent
purpose-driven
assemblies
of
components,
encompassing
cells,
biomaterials,
and
active
agents,
intricately
designed
to
fulfill
diverse
biomedical
applications.
Gelatin
its
derivatives
have
been
used
extensively
in
ELSs
owing
their
mature
translational
pathways,
favorable
biological
properties,
adjustable
physicochemical
characteristics.
This
review
explores
the
intersection
gelatin
with
fabrication
techniques,
offering
a
comprehensive
examination
synergistic
potential
creating
for
various
applications
biomedicine.
It
offers
deep
dive
into
gelatin,
including
structures
production,
sources,
processing,
properties.
Additionally,
techniques
employing
derivatives,
generic
microfluidics,
3D
printing
methods.
Furthermore,
it
discusses
based
on
regenerative
engineering
as
well
cell
therapies,
bioadhesives,
biorobots,
biosensors.
Future
directions
challenges
are
also
examined,
highlighting
emerging
trends
areas
improvements
innovations.
In
summary,
this
underscores
significance
gelatin-based
advancing
lays
groundwork
guiding
future
research
developments
within
field.
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(4)
Опубликована: Март 28, 2025
ABSTRACT
Bone
repair
is
a
complex
biological
process
requiring
dynamic
interplay
between
cellular
mechanisms,
molecular
signaling,
and
environmental
factors.
The
intricate
stages
of
bone
healing,
including
hematoma
formation,
inflammation,
soft
callus
development,
hard
remodeling,
are
driven
by
coordinated
responses
pathways.
Proinflammatory
cytokines,
growth
factors,
the
extracellular
matrix
play
critical
roles
in
promoting
osteogenesis
angiogenesis.
Factors
such
as
age,
systemic
health,
mechanical
stability
significantly
influence
efficiency.
To
address
limitations
natural
advancements
regenerative
medicine
have
introduced
innovative
materials
like
nanocomposite
hydrogels,
which
mimic
microenvironment
enhance
function.
Semi‐interpenetrating
network
(semi‐IPN)
hydrogels
emerged
promising
tool
for
tissue
engineering.
Combining
crosslinked
non‐crosslinked
polymers,
these
offer
balance
stability,
functionality,
controlled
degradation.
Semi‐IPN
provide
structural
support,
facilitate
cell
attachment,
enable
sustained
release
bioactive
molecules.
Their
flexibility
adaptability
make
them
suitable
encapsulating
stem
cells
targeted
regeneration.
Moreover,
nonsurgical
surgical
scaffold
delivery
methods,
ranging
from
injectable
to
3D‐printed
magnetically
guided
scaffolds,
expanded
horizons
strategies,
reduced
invasiveness,
improved
patient
outcomes.
This
review
explores
dynamics
role
regeneration,
advanced
construction
strategies
semi‐IPN
repair.
By
integrating
polymer
science,
nanotechnology,
bioengineering,
represent
transformative
shift
addressing
defects,
paving
way
therapeutic
approaches
medicine.
With
ongoing
advancements,
technologies
hold
significant
potential
improve
effectiveness
accessibility
solutions.
Science,
Год журнала:
2025,
Номер
388(6747), С. 616 - 623
Опубликована: Май 8, 2025
Three-dimensional
printing
offers
promise
for
patient-specific
implants
and
therapies
but
is
often
limited
by
the
need
invasive
surgical
procedures.
To
address
this,
we
developed
an
imaging-guided
deep
tissue
in
vivo
sound
(DISP)
platform.
By
incorporating
cross-linking
agent–loaded
low-temperature–sensitive
liposomes
into
bioinks,
DISP
enables
precise,
rapid,
on-demand
of
diverse
functional
biomaterials
using
focused
ultrasound.
Gas
vesicle–based
ultrasound
imaging
provides
real-time
monitoring
allows
customized
pattern
creation
live
animals.
We
validated
successfully
near
diseased
areas
mouse
bladder
within
rabbit
leg
muscles
vivo,
demonstrating
its
potential
localized
drug
delivery
replacement.
DISP’s
ability
to
print
conductive,
drug-loaded,
cell-laden,
bioadhesive
demonstrates
versatility
biomedical
applications.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12567 - 12567
Опубликована: Ноя. 22, 2024
Constructing
scaffolds
with
the
desired
structures
and
functions
is
one
of
main
goals
tissue
engineering.
Three-dimensional
(3D)
bioprinting
a
promising
technology
that
enables
personalized
fabrication
devices
regulated
biological
mechanical
characteristics
similar
to
natural
tissues/organs.
To
date,
3D
has
been
widely
explored
for
biomedical
applications
like
engineering,
drug
delivery,
screening,
in
vitro
disease
model
construction.
Among
different
bioinks,
photocrosslinkable
bioinks
have
emerged
as
powerful
choice
advanced
devices,
fast
crosslinking
speed,
high
resolution,
great
print
fidelity.
The
biomaterials
used
light-based
printing
play
pivotal
role
functional
constructs.
Herein,
this
review
outlines
general
approaches
related
biomaterials,
including
extrusion-based
printing,
inkjet
stereolithography
laser-assisted
printing.
Further,
mechanisms,
advantages,
limitations
photopolymerization
photoinitiators
are
discussed.
Next,
recent
advances
synthetic
highlighted.
Finally,
challenges
future
perspectives
envisaged.
Abstract
Current
two-dimensional
(2D)
cell
models
for
effective
drug
screening
suffer
from
significant
limitations
imposed
by
the
lack
of
realism
in
physiological
environment.
Three-dimensional
(3D)
organoids
hold
immense
potential
mimicking
key
functions
human
organs
overcoming
traditional
2D
models.
However,
current
techniques
preparation
3D
had
reproducibility,
scalability,
and
ability
to
closely
replicate
complex
microenvironment
found
vivo
.
Additionally,
culture
systems
often
involve
lengthy
labor-intensive
processes
that
hinder
high-throughput
applications
necessary
a
large-scale
screening.
Advancements
bioprinting
technologies
offer
promising
solutions
these
challenges
enabling
precise
spatial
control
over
placement
material
composition,
thereby
facilitating
creation
more
physiologically
relevant
than
techniques.
This
review
provides
comprehensive
summary
recent
advances
creating
models,
which
begins
with
an
introduction
different
types
(especially
focus
on
volumetric
(VBP)
technique),
followed
overview
bioinks
utilized
bioprinting.
Moreover,
we
also
introduce
disease
efficiency
evaluation
regenerative
medicine.
Finally,
possible
strategies
development
clinical
translation
are
concluded.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 4, 2025
Technological
advances
have
significantly
impacted
the
field
of
urology,
providing
innovative
solutions
for
diagnosis,
treatment,
and
management
various
urological
disorders
diseases.
This
article
highlights
four
groundbreaking
technologies:
whole-cell
biosensors,
optogenetic
interventions
neuromodulation,
bioengineered
urinary
bladder,
3D
bioprinting.
Each
technology
plays
a
crucial
role
in
enhancing
patient
care
improving
clinical
outcomes
urology.
Advances
these
fields
underscore
shift
towards
precision
diagnostics,
personalized
treatments,
enhanced
regenerative
strategies,
ultimately
aiming
to
enhance
address
unmet
needs
