Connecting the dots: the role of fatigue in female infertility DOI Creative Commons
Wenzhu Li, Xiaoyan Huang, Yiqiu Wei

и другие.

Reproductive Biology and Endocrinology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 7, 2024

Abstract Fatigue, an increasingly acknowledged symptom in various chronic diseases, has garnered heightened attention, during the medical era of bio-psycho-social model. Its persistence not only significantly compromises individual’s quality life but also correlates with organ damage. Surprisingly, intricate relationship between fatigue and female reproductive health, specifically infertility, remains largely unexplored. Our exploration into existing body evidence establishes a compelling link uterine ovarian as well conditions associated such rheumatism. This observation suggests potentially pivotal role influencing overall fertility. Furthermore, we propose hypothetical mechanism elucidating impact on infertility from multiple perspectives, postulating that neuroendocrine, neurotransmitter, inflammatory immune, mitochondrial dysfunction resulting its co-factors may further contribute to endocrine disorders, menstrual irregularities, sexual dysfunction, ultimately leading infertility. In addition providing this comprehensive theoretical framework, summarize anti-fatigue strategies accentuate current knowledge gaps. By doing so, our aim is offer novel insights, stimulate research, advance understanding crucial interplay health.

Язык: Английский

Bi-allelic variants in DNAH3 cause male infertility with asthenoteratozoospermia in humans and mice DOI Creative Commons

Guiquan Meng,

Yaling Wang, Chen Luo

и другие.

Human Reproduction Open, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Abstract STUDY QUESTION Are there other pathogenic genes for asthenoteratozoospermia (AT)? SUMMARY ANSWER DNAH3 is a novel candidate gene AT in humans and mice. WHAT IS KNOWN ALREADY major cause of male infertility. Several underlying have been reported; however, the genetic aetiology remains unknown majority affected men. DESIGN, SIZE, DURATION A total 432 patients with were recruited this study. mutations identified by whole-exome sequencing (WES). Dnah3 knockout mice generated using genome editing tool. The morphology motility sperm from investigated. entire study was conducted over 3 years. PARTICIPANTS/MATERIALS, SETTING, METHODS WES performed on infertile AT. In addition, two lines generated. Haematoxylin eosin (H&E) staining, transmission electron microscopy (TEM), immunostaining, computer-aided analysis (CASA) to investigate spermatozoa. ICSI used overcome infertility one patient MAIN RESULTS AND THE ROLE OF CHANCE biallelic variants three unrelated families. H&E staining revealed various morphological abnormalities flagella patients, TEM immunostaining further showed loss central pair microtubules, dislocated mitochondrial sheath fibrous sheath, as well partial absence inner dynein arms. mouse demonstrated One good treatment outcomes after ICSI. LARGE SCALE DATA N/A. LIMITATIONS, REASONS FOR CAUTION This preliminary report suggesting that defects can lead mechanism needs be examined future WIDER IMPLICATIONS FINDINGS Our findings show provide crucial insights into biological underpinnings disorder. may also beneficial counselling individuals. FUNDING/COMPETING INTEREST(S) work supported grants National Natural Science Foundation China (82201773, 82101961, 82171608, 32322017, 82071697, 81971447), Key Research Development Program (2022YFC2702604), Scientific Health Committee Hunan Province (B202301039323, B202301039518), Provincial (2023JJ30716), Medical Innovation Project Fujian (2020-CXB-051), Technology (2023D017), Postdoctoral (2022M711119), Guilin technology project people’s benefit (20180106-4-7). authors declare no competing interests.

Язык: Английский

Процитировано

16
Rejuvenation of aged oocyte through exposure to young follicular microenvironment DOI
Haiyang Wang, Zhongwei Huang,

Xingyu Shen

и другие.

Nature Aging, Год журнала: 2024, Номер 4(9), С. 1194 - 1210

Опубликована: Сен. 9, 2024

Язык: Английский

Процитировано

16
Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage DOI

Shiqi Zhu,

Peng Xie, Yi Yang

и другие.

Nature Structural & Molecular Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Язык: Английский

Процитировано

1
Comparative proteomic landscapes elucidate human preimplantation development and failure DOI
Wencheng Zhu, Juan Meng, Yán Li

и другие.

Cell, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Association between per- and polyfluoroalkyl substances and sex hormone levels in males based on human studies DOI Creative Commons
Lingli Sang, Yue Ge,

Fucun Liu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 271, С. 115998 - 115998

Опубликована: Янв. 22, 2024

Per- and poly-fluoroalkyl substances (PFAS) are ubiquitous chemicals in the environment our daily lives. Several epidemiological studies have revealed that PFAS exposure is linked to male sex hormone levels; however, conclusions inconsistent across studies. Consequently, we performed a meta-analysis systematically evaluate association between hormones. The Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) standards were followed during meta-analysis. PubMed, Wed of Science, Embase, Cochrane Library, Ovid databases used identify suitable articles before June 2023. 95% CI β values calculated assess levels exposure. Heterogeneity among included was tested using inconsistency statistics (I2). literature search identified 12 published met criteria, involving 7506 participants. Our results perfluorononanoic acid (PFNA) perfluorooctanoic (PFOA) exposures negatively correlated with testosterone (β = –0.05; CI: –0.09, –0.02, P 0.003) –0.04; –0.08, 0.00, 0.049), respectively. Exposure PFNA PFOA changes levels. This correlation suggests need pay attention future whether they potential risk factors reproductive health.

Язык: Английский

Процитировано

7
Population decline: where demography, social science and biology intersect DOI Creative Commons
R. John Aitken

Reproduction, Год журнала: 2024, Номер 168(1)

Опубликована: Апрель 5, 2024

In brief Over the past half century, world has witnessed an unprecedented decline in human fertility rates. This analysis reviews various socioeconomic, cultural, and biological factors involved driving this change considers whether low rates are a temporary or permanent feature of our future demographic profile. Abstract Since early 1960s, spectacular collapse fertility. As result phenomenon, several countries already seeing their population numbers fall more will follow coming decades. The causes involve complex interplay socio-economic, environmental, that have converged to constrain posterity’s wake. large offspring no longer needed compensate for high infant mortality contemporary society, couples opted small families quality-over-quantity investment progeny’s future. Simultaneously, increases female education, enhanced participation women paid workforce, resultant delay childbearing placed limits on achievable family size. Progressive urbanization, improved availability contraceptives, socio-economic pressures experienced by young adults ageing societies also contributing fertility’s demise. These factors, together with individualism pervades modern society increasing social acceptability voluntary childlessness, firmly established ethos most post-transition countries. none these forces about relent, it looks as if extremely might be us some time come. may long-term consequences. lack selection pressure genotypes, ability ART retain poor genotypes within population, sustained exposure reproductive toxicants industrialized environments all contrive leave mark fecundity species.

Язык: Английский

Процитировано

6
Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models DOI Creative Commons
Zhiming Li,

Hongyi Xian,

Xiaohu Ren

и другие.

Environment & Health, Год журнала: 2024, Номер 2(7), С. 424 - 440

Опубликована: Май 4, 2024

Triclosan (TCS) has garnered significant attention due to its widespread use and associated endocrine-disrupting effects. However, impact on the neuroendocrine system underlying mechanisms remain poorly understood. Here, we established correlations between TCS exposure serum sex hormone levels in participants of National Health Nutrition Examination Survey (NHANES). Additionally, investigated TCS's influence using adult zebrafish exposed environmentally relevant concentrations (0.361–48.2 μg/L) for 21 days. Assessment reproductive neurotoxicity included histopathological examination behavioral tests. Transcriptomics, proteomics analyses, biochemical detection were employed elucidate TCS-induced disruption. Significant found estradiol, testosterone, hormone-binding globulin NHANES participants. In addition, inhibited ovary development spermatogenesis zebrafish. Transcriptomics analysis revealed gender-specific key signaling metabolism-related pathways implicated toxicity. Moreover, induced nervous impairment, as evidenced by histological changes altered motor behavior, possibly with oxidative damage. Correlation further highlighted potential connection endocrine disruption impairment following exposure. Overall, this study provided evidence supporting offered insights into mechanisms.

Язык: Английский

Процитировано

5
The landscape of RNA binding proteins in mammalian spermatogenesis DOI
Yang Li, yuanyuan wang, Yue‐Qiu Tan

и другие.

Science, Год журнала: 2024, Номер 386(6720)

Опубликована: Авг. 29, 2024

Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack systematic understanding RBPs in mammalian testis, which harbors one most complex tissue transcriptomes. We adapted interactome capture to mouse male germ cells, building an RBP atlas characterized by multiple layers dynamics along spermatogenesis. Trapping RNA-cross-linked peptides showed that glutamic acid-arginine (ER) patch, residue-coevolved polyampholytic element present coiled coils, enhances its host RBPs. Deletion this NONO (non-POU domain-containing octamer-binding protein) led defective mitosis-to-meiosis transition due compromised NONO-RNA interactions. Whole-exome sequencing over 1000 infertile men revealed prominent role human genetic architecture infertility and identified risk ER patch variants.

Язык: Английский

Процитировано

5
Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence DOI Creative Commons
Weicheng Tang, Kaichen Wang, Yourong Feng

и другие.

Life Medicine, Год журнала: 2025, Номер 4(1)

Опубликована: Янв. 23, 2025

The ovary is a crucial gonadal organ that supports female reproductive and endocrine functions. Ovarian aging can result in decreased fertility dysfunction across multiple organs. Research has demonstrated cellular senescence various cell types within the trigger decline ovarian function through distinct stress responses, resulting aging. This review explores how may contribute to failure. Additionally, we discuss factors cause senescence, including accumulation of advanced glycation end products, oxidative stress, mitochondrial dysfunction, DNA damage, telomere shortening, exposure chemotherapy. Furthermore, six types, oocytes, granulosa cells, theca immune surface epithelium, endothelial inside explore their contribution accelerated Lastly, describe potential senotherapeutics for treatment offer novel strategies longevity.

Язык: Английский

Процитировано

0
Relationship of Early Embryonic Development In Vitro Fertilization With Sperm Zinc Homeostasis and Seminal Plasma Antioxidation DOI Creative Commons
Mengze Du,

Hu Yizhen,

Yang Dan

и другие.

Andrologia, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

The study aims to explore the sperm parameters that affect early embryo development in vitro fertilization (IVF) and their relationship with zinc homeostasis seminal plasma antioxidation. semen samples were incubated at 37°C for 1, 2, 3, 4 h, progressive motility (PR) was analyzed. We found PR significantly decreased after 3 h of incubation ( p < 0.01) further 0.001). correlation analysis showed significant positively correlated transferable rate r = 0.155, 0.026) blastocyst formation 0.140, 0.044) while its decline negatively −0.151, 0.030) −0.220, 0.002). Additionally, ELISA assay indicated patients > 32% 30% had higher levels total antioxidant capacity (T‐AOC) superoxide dismutase (SOD) compared 0.05), malondialdehyde (MDA) lower 0.05). results fluorescence probe level free ion high low group than quantitative real‐time polymerase chain reaction (qRT‐PCR) immunofluorescence relative expression G protein‐coupled receptor 39 (GPR39), anoctamin 1 (ANO1), transporter protein 13 (ZIP13) mRNA In conclusion, poor IVF. This may be through reduction homeostasis‐associated accelerate oxidative stress process, thereby reducing quality ultimately affecting embryonic development.

Язык: Английский

Процитировано

0