bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
SUMMARY
Prosocial
behaviors,
such
as
rescuing
individuals
in
need,
are
crucial
for
social
cohesion
across
species.
While
key
brain
regions
involved
rescue
behavior
have
been
identified,
the
underlying
neural
mechanisms
remain
unclear.
The
hippocampus
(HPC),
known
its
role
memory
and
spatial
navigation,
also
contributes
to
emotional
processing.
However,
specific
involvement
prosocial
is
not
well
understood.
Here,
we
investigate
causal
of
HPC
learning
executing
mice.
Using
chemogenetics,
show
that
dorsal
(dHPC),
but
ventral
(vHPC),
essential
acquiring
behavior.
Calcium
imaging
dHPC
reveals
network
consolidation
during
successful
rescues,
with
distinct
synchronized
ensembles
activity
patterns
linked
liberations
an
individual
need.
These
findings
establish
a
novel
behavior,
providing
insights
into
empathy-driven
actions.
Abstract
The
mammalian
hippocampus
contains
a
cognitive
map
that
represents
an
animal’s
position
in
the
environment
1
and
generates
offline
“replay”
2,3
for
purposes
of
recall
4
,
planning
5,6
forming
long
term
memories
7
.
Recently,
it’s
been
found
artificial
neural
networks
trained
to
predict
sensory
inputs
develop
spatially
tuned
cells
8
aligning
with
predictive
theories
hippocampal
function
9–11
However,
whether
learning
can
also
account
ability
produce
replay
is
unknown.
Here,
we
find
spatially-tuned
cells,
which
robustly
emerge
from
all
forms
learning,
do
not
guarantee
presence
generate
replay.
Offline
simulations
only
emerged
used
recurrent
connections
head-direction
information
multi-step
observation
sequences,
promoted
formation
continuous
attractor
reflecting
geometry
environment.
These
trajectories
were
able
show
wake-like
statistics,
autonomously
recently
experienced
locations,
could
be
directed
by
virtual
head
direction
signal.
Further,
make
cyclical
predictions
future
sequences
rapidly
learn
produced
sweeping
representations
positions
reminiscent
theta
sweeps
12
results
demonstrate
how
hippocampal-like
representation
engaged
suggest
reflect
circuit
implements
data-efficient
algorithm
sequential
learning.
Together,
this
framework
provides
unifying
theory
functions
hippocampal-inspired
approaches
intelligence.
Science,
Год журнала:
2024,
Номер
385(6710), С. 738 - 743
Опубликована: Авг. 15, 2024
Memory
consolidation
involves
the
synchronous
reactivation
of
hippocampal
cells
active
during
recent
experience
in
sleep
sharp-wave
ripples
(SWRs).
How
this
increase
firing
rates
and
synchrony
after
learning
is
counterbalanced
to
preserve
network
stability
not
understood.
We
discovered
a
event
generated
by
an
intrahippocampal
circuit
formed
subset
CA2
pyramidal
cholecystokinin-expressing
(CCK+)
basket
cells,
which
fire
barrage
action
potentials
(“BARR”)
non–rapid
eye
movement
sleep.
CA1
neurons
assemblies
that
increased
their
activity
were
reactivated
SWRs
but
inhibited
BARRs.
The
initial
returned
baseline
through
This
trend
was
abolished
silencing
CCK+
BARRs,
resulting
higher
impaired
memory
consolidation.
The
experience-dependent
spatial
cognitive
process
requires
sequential
organization
of
hippocampal
neural
activities
by
theta
rhythm,
which
develops
to
represent
highly
compressed
information
for
rapid
learning.
However,
how
the
sequences
were
developed
in
a
finer
time
scale
within
cycles
remains
unclear.
In
this
study,
we
found
that
sweep-ahead
structure
developing
with
exploration
was
predominantly
dependent
on
relatively
large
proportion
FG-cells,
i.e.
subset
place
cells
dominantly
phase-locked
fast
gamma
rhythms.
These
ensembles
integrated
consistently
firing
at
precessing
slow
phases
cycle.
Accordingly,
FG-cell
positively
correlated
intensity
phase
precession,
particular
during
early
development
sequences.
findings
highlight
dynamic
network-modulation
and
may
further
facilitate
memory
encoding
retrieval.
Science,
Год журнала:
2024,
Номер
385(6710), С. 776 - 784
Опубликована: Авг. 15, 2024
The
entorhinal
cortex
represents
allocentric
spatial
geometry
and
egocentric
speed
heading
information
required
for
navigation.
However,
it
remains
unclear
whether
contributes
to
the
prediction
of
an
animal's
future
location.
We
discovered
grid
cells
in
medial
(MEC)
that
have
fields
representing
locations
during
goal-directed
behavior.
These
predictive
represented
prospective
by
shifting
their
against
direction
travel.
Predictive
discharged
at
trough
phases
hippocampal
CA1
theta
oscillation
and,
together
with
other
types
cells,
organized
sequences
trajectory
from
current
positions
across
each
cycle.
Our
results
suggest
MEC
provides
a
map
supports
forward
planning
