Neuronal networks in the dorsal hippocampus causally regulate rescue behavior in mice DOI Creative Commons
Moisés dos Santos Corrêa,

Anna Agafonova,

Alexandra Braun

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

SUMMARY Prosocial behaviors, such as rescuing individuals in need, are crucial for social cohesion across species. While key brain regions involved rescue behavior have been identified, the underlying neural mechanisms remain unclear. The hippocampus (HPC), known its role memory and spatial navigation, also contributes to emotional processing. However, specific involvement prosocial is not well understood. Here, we investigate causal of HPC learning executing mice. Using chemogenetics, show that dorsal (dHPC), but ventral (vHPC), essential acquiring behavior. Calcium imaging dHPC reveals network consolidation during successful rescues, with distinct synchronized ensembles activity patterns linked liberations an individual need. These findings establish a novel behavior, providing insights into empathy-driven actions.

Язык: Английский

Sleep microstructure organizes memory replay DOI Creative Commons
Hongyu Chang, Wenbo Tang,

Annabella M. Wulf

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

6

Replay of incidentally encoded episodic memories in the rat DOI Creative Commons

Cassandra L. Sheridan,

Stephen Lang,

Mya Knappenberger

и другие.

Current Biology, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

13

Retuning of hippocampal representations during sleep DOI
Kourosh Maboudi, Bapun Giri, Hiroyuki Miyawaki

и другие.

Nature, Год журнала: 2024, Номер 629(8012), С. 630 - 638

Опубликована: Май 8, 2024

Язык: Английский

Процитировано

13

Sequential predictive learning is a unifying theory for hippocampal representation and replay DOI
Daniel Levenstein, Aleksei Efremov, Roy Henha Eyono

и другие.

Опубликована: Апрель 29, 2024

Abstract The mammalian hippocampus contains a cognitive map that represents an animal’s position in the environment 1 and generates offline “replay” 2,3 for purposes of recall 4 , planning 5,6 forming long term memories 7 . Recently, it’s been found artificial neural networks trained to predict sensory inputs develop spatially tuned cells 8 aligning with predictive theories hippocampal function 9–11 However, whether learning can also account ability produce replay is unknown. Here, we find spatially-tuned cells, which robustly emerge from all forms learning, do not guarantee presence generate replay. Offline simulations only emerged used recurrent connections head-direction information multi-step observation sequences, promoted formation continuous attractor reflecting geometry environment. These trajectories were able show wake-like statistics, autonomously recently experienced locations, could be directed by virtual head direction signal. Further, make cyclical predictions future sequences rapidly learn produced sweeping representations positions reminiscent theta sweeps 12 results demonstrate how hippocampal-like representation engaged suggest reflect circuit implements data-efficient algorithm sequential learning. Together, this framework provides unifying theory functions hippocampal-inspired approaches intelligence.

Язык: Английский

Процитировано

11

Remapping revisited: how the hippocampus represents different spaces DOI
André A. Fenton

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(6), С. 428 - 448

Опубликована: Май 7, 2024

Язык: Английский

Процитировано

11

A hippocampal circuit mechanism to balance memory reactivation during sleep DOI
Lindsay A. Karaba, Heath L. Robinson, Ryan E. Harvey

и другие.

Science, Год журнала: 2024, Номер 385(6710), С. 738 - 743

Опубликована: Авг. 15, 2024

Memory consolidation involves the synchronous reactivation of hippocampal cells active during recent experience in sleep sharp-wave ripples (SWRs). How this increase firing rates and synchrony after learning is counterbalanced to preserve network stability not understood. We discovered a event generated by an intrahippocampal circuit formed subset CA2 pyramidal cholecystokinin-expressing (CCK+) basket cells, which fire barrage action potentials (“BARR”) non–rapid eye movement sleep. CA1 neurons assemblies that increased their activity were reactivated SWRs but inhibited BARRs. The initial returned baseline through This trend was abolished silencing CCK+ BARRs, resulting higher impaired memory consolidation.

Язык: Английский

Процитировано

10

Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences DOI Open Access
Ning Wang, Yimeng Wang,

Mingkun Guo

и другие.

Опубликована: Фев. 17, 2025

The experience-dependent spatial cognitive process requires sequential organization of hippocampal neural activities by theta rhythm, which develops to represent highly compressed information for rapid learning. However, how the sequences were developed in a finer time scale within cycles remains unclear. In this study, we found that sweep-ahead structure developing with exploration was predominantly dependent on relatively large proportion FG-cells, i.e. subset place cells dominantly phase-locked fast gamma rhythms. These ensembles integrated consistently firing at precessing slow phases cycle. Accordingly, FG-cell positively correlated intensity phase precession, particular during early development sequences. findings highlight dynamic network-modulation and may further facilitate memory encoding retrieval.

Язык: Английский

Процитировано

1

Dynamic prediction of goal location by coordinated representation of prefrontal-hippocampal theta sequences DOI
Yimeng Wang, Xueling Wang, Ling Wang

и другие.

Current Biology, Год журнала: 2024, Номер 34(9), С. 1866 - 1879.e6

Опубликована: Апрель 11, 2024

Язык: Английский

Процитировано

7

Prefrontal cortical ripples mediate top-down suppression of hippocampal reactivation during sleep memory consolidation DOI
Justin D. Shin, Shantanu P. Jadhav

Current Biology, Год журнала: 2024, Номер 34(13), С. 2801 - 2811.e9

Опубликована: Июнь 3, 2024

Язык: Английский

Процитировано

6

Predictive grid coding in the medial entorhinal cortex DOI
Ayako Ouchi, Shigeyoshi Fujisawa

Science, Год журнала: 2024, Номер 385(6710), С. 776 - 784

Опубликована: Авг. 15, 2024

The entorhinal cortex represents allocentric spatial geometry and egocentric speed heading information required for navigation. However, it remains unclear whether contributes to the prediction of an animal's future location. We discovered grid cells in medial (MEC) that have fields representing locations during goal-directed behavior. These predictive represented prospective by shifting their against direction travel. Predictive discharged at trough phases hippocampal CA1 theta oscillation and, together with other types cells, organized sequences trajectory from current positions across each cycle. Our results suggest MEC provides a map supports forward planning

Язык: Английский

Процитировано

6