Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(12), С. 101186 - 101186
Опубликована: Дек. 1, 2024
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Язык: Английский
Molecular Therapy, Год журнала: 2025, Номер 33(3), С. 986 - 996
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
1
Bioelectronic Medicine, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 20, 2025
Abstract The field of bioelectronic medicine has advanced rapidly from rudimentary electrical therapies to cutting-edge closed-loop systems that integrate real-time physiological monitoring with adaptive neuromodulation. Early innovations, such as cardiac pacemakers and deep brain stimulation, paved the way for these sophisticated technologies. This review traces historical technological progression medicine, culminating in emerging potential devices multiple disorders body. We emphasize both invasive techniques, implantable brain, spinal cord autonomic regulation, while we introduce new prospects non-invasive neuromodulation, including focused ultrasound newly developed neurography enabling precise detection titration inflammatory immune responses. case neuromodulation (incorporating splenic stimulation) is presented through its applications conditions sepsis chronic inflammation, illustrating capacity revolutionize personalized healthcare. Today, or have yet be dynamically modulate nervous system function by responding molecular signals; it represents a transformative approach therapeutic interventions major opportunity which may advance. Knowledge gaps remain likely contribute lack available closed loop systems, namely, (1) significant exogenous endogenous noise must filtered out, (2) drift signal due temporal change disease severity and/or therapy induced neuroplasticity, (3) confounding effects (e.g., concurrent medications dysregulate functions). Leveraging continuous feedback adjustments overcome many barriers, next generation stand at forefront precision offering avenues individualized treatment.
Язык: Английский
Процитировано
1
Brain stimulation, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
We aim to determine the maximum safe spatial-peak pulse-average intensity (ISPPA) of low-intensity focused ultrasound stimulation (LIFUS) in stroke patients and explore its effect on motor learning corticospinal excitability. adopted classic 3+3 design escalate ISPPA (estimated in-vivo transcranial value) from 0, 1, 2, 4, 6, 8 W/cm2. Stopping rules were pre-defined: 2nd-degree scalp burn, clinical seizure, new lesion diffusion-weighted imaging or major reduction apparent diffusion coefficient, participant discontinuation due any reason. applied 12-minute LIFUS over ipsilesional cortex while participants concurrently practicing 3 blocks a sequence (MSL) task using affected hand. measured MSL (response time) excitability (motor evoked potential) pre- post-stimulation compared between LOW (0, 2 W/cm2) HIGH (4, groups. was escalated W/cm2 with 18 without meeting stopping rules. Compared LOW, more performed better (6/9 vs. 0/9, p = 0.009) showed sign greater (7/9 5/9, 0.62). Our phase-I safety study suggests that one session up is feasible patients, high induces positive changes both The next logical step conduct phase-II trial testing efficacy continuously monitoring profiles.
Язык: Английский
Процитировано
0
Applied Sciences, Год журнала: 2025, Номер 15(4), С. 1707 - 1707
Опубликована: Фев. 7, 2025
This study investigates the impact of low-intensity continuous ultrasound (LICU) on pancreatic adenocarcinoma (PANC-1) spheroids, emphasizing morphological and volumetric transformations. PANC-1 spheroids were cultured treated with LICU across frequencies from 1 to 5 MHz. Cell viability mortality analyzed through Calcein AM/PI staining, while changes quantified 2 4 MHz using advanced imaging techniques computational tools, including a custom Python OpenCv Library, AnaSP 3.0, MATLAB based open source tool. Notably, frequency 3.5 yielded optimal outcomes, also achieving reduction in spheroid volume minimizing disgregation, factor linked metastasis risk. These findings underscore LICU’s potential as an effective therapeutic strategy, balancing tumor preservation structural cohesion. The establishes methodological framework for optimizing parameters, presenting less invasive avenue improving outcomes cancer treatment.
Язык: Английский
Процитировано
0
Chemical Society Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Hydrogels are emerging as promising candidates for brain–computer interfaces. This review highlights the current advancements in implantable hydrogel electrodes neural signal recording, neuromodulation, and brain disorder treatment.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Transcranial ultrasound holds great potential in medical applications. However, the effective transmission of through skull remains challenging due to acoustic impedance mismatch, as well non-uniform thickness, and curved surface. To overcome these challenges, this work introduces an innovative Mie-resonance flexible metamaterial (MRFM), which consists periodically arranged low-speed micropillars embedded within a high-speed substrate. The MRFM generates Mie-resonance, couples with form Fano resonance, thereby enhancing transmittance skull. Simulation results demonstrate that proposed resonance solution significantly increases transcranial from 33.7% 75.2% at 0.309 MHz. For fabrication MRFM, porous nickel foam is used Mie micropillars, agarose hydrogel serves Experimental enhanced 20.6% 73.3% 0.33 MHz shows good agreement simulation results, further validating effectiveness design. simplicity, tunability, flexibility represent significant breakthrough, addressing limitations conventional rigid metamaterials. This lays solid theoretical experimental foundation for advancing clinical application stimulation neuromodulation.
Язык: Английский
Процитировано
0
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 1, 2025
To evaluate the efficacy and safety of ultrasound-guided percutaneous thermal ablation for abdominal wall metastases. We retrospectively analyzed patients with metastatic nodules who underwent microwave (MWA) from August 2018 to September 2024. Tumor volume (V), reduction rate (VRR), pain scores, University Washington Quality Life (Uw-QOL) scores were measured at one, three, six months postoperative. A total twelve included in study (8 males 4 females), one male patient excluded due incomplete follow-up data. The median age was 51.5 years (range: 37–75). All successfully treated, no local recurrence noted during follow-up. rates 45.4%, 76.9%, 96% months, respectively. By end period, average decreased significantly 7.09 ± 0.70 2.18 1.16 (p < 0.001). quality life improved, Uw-Qol score increased 1148.63 94.07 1269.54 118.25 0.05). No appeared serious complications. clinical symptoms all improved. Ultrasound-guided is a safe effective minimally invasive method treatment wall, presenting viable option are unsuitable or unwilling undergo surgery.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Various antitumor strategies have emerged to address the escalating need for effective tumor eradication. However, achieving precise and spatiotemporally controlled dynamic therapies remains promising yet challenging. Sonopiezoelectric nanotherapy eliminates cells by generating reactive oxygen species (ROS) through ultrasound stimulation, enabling spatiotemporal control ensuring safety during deep tissue penetration. In this study, a hybrid bioscaffold incorporating few-layer black phosphorus (BP) nitric oxide (NO) donors are rationally designed engineered sonopiezoelectric-gaseous synergistic therapy. This ultrasound-responsive system provides stepwise countermeasure against invasion in bone tissues. Ultrasonic vibration induces mechanical strain BP nanosheets, leading piezoelectric polarization subsequent ROS generation. Moreover, ultrasound-triggered NO burst release from enables gas The effects of sonopiezoelectric therapy ultrasound-excited enhance eradication, effectively inhibiting proliferation metastasis while minimizing off-target cytotoxicity. Additionally, biomineralization capability degradable proangiogenic low-concentration establish as bioactive platform that facilitates regeneration. development 4D multifunctional therapeutic platform, characterized superior efficacy, release, stimulatory on regeneration, offers new insights into comprehensive treatment invasive tumors.
Язык: Английский
Процитировано
0
Cell Reports Medicine, Год журнала: 2025, Номер unknown, С. 102094 - 102094
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Ultrasound in Medicine, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 11, 2024
A 2012 review of therapeutic ultrasound was published to educate researchers and physicians on potential applications concerns for unintended bioeffects (doi: 10.7863/jum.2012.31.4.623). This serves as an update the parent article, highlighting advances in over past 12 years. In addition general mechanisms produced by ultrasound, current applications, pre-clinical clinical stages are outlined. An overview is provided image guidance methods monitor assess treatment progress. Finally, other topics relevant translation discussed, including computational modeling, tissue-mimicking phantoms, quality assurance protocols.
Язык: Английский
Процитировано
1