Role of the microbiota in response to and recovery from cancer therapy

Nature reviews. Immunology, Год журнала: 2023, Номер 24(5), С. 308 - 325

Опубликована: Ноя. 6, 2023

Язык: Английский

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Long-distance microbial mechanisms impacting cancer immunosurveillance

Immunity, Год журнала: 2024, Номер 57(9), С. 2013 - 2029

Опубликована: Авг. 15, 2024

Язык: Английский

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Fusobacterium nucleatum Promotes the Growth and Metastasis of Colorectal Cancer by Activating E‐Cadherin/Krüppel‐Like Factor 4/Integrin α5 Signaling in a Calcium‐Dependent Manner

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Март 1, 2025

Gut microbiota and integrins are known to contribute colorectal cancer (CRC), but whether they interact has been unclear. Here, we provided evidence that Fusobacterium nucleatum upregulated integrin α5 (ITGA5) in CRC both human patients murine models. Knocking down ITGA5 cells weakened the ability of F. stimulate their malignant characteristics. increased intracellular Ca2+ concentration, which turn promoted interaction between E-cadherin Krüppel-like factor 4 (KLF4), resulting KLF4 phosphorylation translocation nucleus, where it induced transcription activated downstream signaling. or chelating with BAPTA-AM antagonized impact on KLF4, whereas knocking bacteria's oncogenic role. attenuated nucleatum-induced growth patient-derived organoids, subcutaneous xenografts, orthotopic tumors, as well liver metastasis nude mice. Integrin antibody role vitro vivo. These findings suggest promotes by activating E-cadherin/KLF4/integrin signaling a Ca2+-dependent manner.

Язык: Английский

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Au NCs@p53 delivery system triggers a “domino effect” in combination with anti-PD-L1 immunotherapy cascade to potentiate HCC treatment

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162190 - 162190

Опубликована: Март 1, 2025

Язык: Английский

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Assessment of human and mouse tumor-antigen specific CD8 + T cells by multimer staining in multiple compartments

Methods in cell biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Association of CD8+TILs co-expressing granzyme A and interferon-γ with colon cancer cells in the tumor microenvironment

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 19, 2024

Abstract CD8 + T cells secreting granzyme A (GZMA) can induce pyroptosis in tumor by effectively cleaving gasdermin B (GSDMB), which is stimulated interferon-γ (IFN-γ). However, the interaction between GZMA-expressing and GSDMB-expressing colon cancer remains poorly understood. Our research employed multi-color immunohistochemistry (mIHC) staining integrated clinical data to explore spatial distribution relevance of GZMA- IFN-γ-expressing tumor-infiltrating lymphocytes (TILs), as well CK cells, within microenvironment (TME) human samples. Additionally, we utilizing single-cell RNA sequencing (scRNA-seq) examine functional dynamics interactions among these cell populations. scRNA-seq analysis colorectal (CRC) tissues revealed that TILs co-expressed GZMA IFN-γ, but not other types. mIHC results indicated a significant reduction infiltration IFN-γ patients ( P < 0.01). Functional demonstrated enhanced activation effector functions compared TIL subsets. Furthermore, exhibited augmented immunogenicity. Correlation highlighted positive association GSDMB r = 0.221, 0.033). Analysis cell-cell further showed were mediated transforming growth factor-β (TGF-β), co-stimulatory molecule ICOS, immune checkpoint molecules TIGIT TIM-3. These findings suggested modulating significantly impacted patients’ prognosis cancer. By elucidating mechanisms, our present study aims provide novel insights for advancement immunotherapeutic strategies

Язык: Английский

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MAdCAM-1: a newly identified microbial 'gut check' for T cells

Trends in Immunology, Год журнала: 2023, Номер 44(8), С. 568 - 570

Опубликована: Июль 12, 2023

Язык: Английский

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L’immunité intestinale peut contrôler les métastases des cancers du côlon-rectum

médecine/sciences, Год журнала: 2024, Номер 40(2), С. 121 - 123

Опубликована: Фев. 1, 2024

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MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype

Mucosal Immunology, Год журнала: 2024, Номер 17(4), С. 700 - 712

Опубликована: Май 8, 2024

Язык: Английский

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Global trends and focuses of Integrins in Colorectal Cancer: a bibliometric analysis and visualization from 2007 to 2023

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

Colorectal cancer is one of the most common tumors digestive system; however, current treatment methods still have certain limitations. In recent years, researchers found that integrins play a crucial role in colorectal cancer, making them hot topic research. To gain better understanding status and trends research, this study conducted bibliometric analysis for first time to assess development integrin-related research cancer. The selected core dataset from Web Science database included relevant on published between 2007 2023. CiteSpace, VoSviewer, Bibliometrix R packages were utilized analyzing aspects country/region, authors, institutions, journals, references, keywords. revealed steady growth over past 16 with total 1,339 articles by 61 countries. Among them, China has highest number publications, followed United States. frequently cited journal Cancer Research, Journal Biological Chemistry Oncogene. conclusion, provided comprehensive visualization These analytical results not only offer valuable insights but also provide useful information decision-makers scientific medical communities. This, turn, can facilitate improvement

Язык: Английский

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