Immunoregulation through extracellular nucleotides

Blood, Год журнала: 2012, Номер 120(3), С. 511 - 518

Опубликована: Июнь 2, 2012

Язык: Английский

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Detecting adenosine triphosphate in the pericellular space

Interface Focus, Год журнала: 2013, Номер 3(3), С. 20120101 - 20120101

Опубликована: Апрель 23, 2013

Release of adenosine triphosphate (ATP) into the extracellular space occurs in response to a multiplicity physiological and pathological stimuli virtually all cells tissues. A role for ATP has been identified processes as different neurotransmission, endocrine exocrine secretion, smooth muscle contraction, bone metabolism, cell proliferation, immunity inflammation. However, measurement proved daunting task until recently. To tackle this challenge, some years ago, we designed engineered novel luciferase probe targeted expressed on outer aspect plasma membrane. This was constructed by appending firefly N-terminal leader sequence C-terminal glycophosphatidylinositol anchor folate receptor. chimeric protein, named membrane luciferase, is localized side With probe, have generated stably transfected HEK293 clones that act an vitro vivo sensor concentration several disease conditions, such experimentally induced tumours

Язык: Английский

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Bacterial Moonlighting Proteins and Bacterial Virulence

Current topics in microbiology and immunology, Год журнала: 2011, Номер unknown, С. 155 - 213

Опубликована: Янв. 1, 2011

Язык: Английский

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Molecular Mechanisms of Purine and Pyrimidine Nucleotide Release

Advances in pharmacology, Год журнала: 2011, Номер unknown, С. 221 - 261

Опубликована: Янв. 1, 2011

Язык: Английский

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Secreted protein kinases

Trends in Biochemical Sciences, Год журнала: 2012, Номер 38(3), С. 121 - 130

Опубликована: Дек. 29, 2012

Язык: Английский

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