Immunoregulation through extracellular nucleotides

Blood, Journal Year: 2012, Volume and Issue: 120(3), P. 511 - 518

Published: June 2, 2012

Language: Английский

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Detecting adenosine triphosphate in the pericellular space

Interface Focus, Journal Year: 2013, Volume and Issue: 3(3), P. 20120101 - 20120101

Published: April 23, 2013

Release of adenosine triphosphate (ATP) into the extracellular space occurs in response to a multiplicity physiological and pathological stimuli virtually all cells tissues. A role for ATP has been identified processes as different neurotransmission, endocrine exocrine secretion, smooth muscle contraction, bone metabolism, cell proliferation, immunity inflammation. However, measurement proved daunting task until recently. To tackle this challenge, some years ago, we designed engineered novel luciferase probe targeted expressed on outer aspect plasma membrane. This was constructed by appending firefly N-terminal leader sequence C-terminal glycophosphatidylinositol anchor folate receptor. chimeric protein, named membrane luciferase, is localized side With probe, have generated stably transfected HEK293 clones that act an vitro vivo sensor concentration several disease conditions, such experimentally induced tumours

Language: Английский

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Bacterial Moonlighting Proteins and Bacterial Virulence

Current topics in microbiology and immunology, Journal Year: 2011, Volume and Issue: unknown, P. 155 - 213

Published: Jan. 1, 2011

Language: Английский

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Molecular Mechanisms of Purine and Pyrimidine Nucleotide Release

Advances in pharmacology, Journal Year: 2011, Volume and Issue: unknown, P. 221 - 261

Published: Jan. 1, 2011

Language: Английский

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Secreted protein kinases

Trends in Biochemical Sciences, Journal Year: 2012, Volume and Issue: 38(3), P. 121 - 130

Published: Dec. 29, 2012

Language: Английский

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