The role of extracellular vesicles in cancer

Cell, Год журнала: 2023, Номер 186(8), С. 1610 - 1626

Опубликована: Апрель 1, 2023

Язык: Английский

---

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 14, 2023

Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.

Язык: Английский

---

Young Exosome Bio‐Nanoparticles Restore Aging‐Impaired Tendon Stem/Progenitor Cell Function and Reparative Capacity

Advanced Materials, Год журнала: 2023, Номер 35(18)

Опубликована: Фев. 13, 2023

Aging impairs tendon stem/progenitor cell function and homeostasis, however, effective treatments for aging-induced diseases are lacking. Exosomes naturally derived nanoparticles that contain bioactive molecules, therefore, have attracted great interest in tissue engineering regenerative medicine. In this study, it is shown young exosomes secreted by stem cells from human exfoliated deciduous teeth (SHED-Exos) possess abundant anti-aging signals. These bio-nanoparticles can alleviate the aging phenotypes of aged (AT-SCs) maintain their tenogenic capacity. Mechanistically, SHED-Exos modulate histone methylation inhibit nuclear factor-κB to reverse AT-SC aging. a mouse model, systemic administration SHED-Exo retards degeneration. Interestingly, local delivery SHED-Exos-loaded microspheres confers phenotypes, including reduced senescent decreased ectopic bone formation, thereby functionally structurally rescuing endogenous regeneration repair capacity rats. Overall, SHED-Exos, as natural nanoparticles, promising translational therapeutic potential aging-related diseases.

Язык: Английский

---

Stress, epigenetics, and aging: Unraveling the intricate crosstalk

Molecular Cell, Год журнала: 2023, Номер 84(1), С. 34 - 54

Опубликована: Ноя. 13, 2023

Язык: Английский

---

Therapeutic potential of RNA-enriched extracellular vesicles: The next generation in RNA delivery via biogenic nanoparticles

Molecular Therapy, Год журнала: 2024, Номер 32(9), С. 2939 - 2949

Опубликована: Фев. 27, 2024

Язык: Английский

---

Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

Science Advances, Год журнала: 2024, Номер 10(15)

Опубликована: Апрель 12, 2024

Aging skin, vulnerable to age-related defects, is poor in wound repair. Metabolic regulation accumulated senescent cells (SnCs) with aging essential for tissue homeostasis, and adequate ATP important cell activation aged Strategies metabolism intervention hold prospects therapeutic advances. Here, we found energy metabolic changes skin from patients mice. Our data show that metformin engineered EV (Met-EV) can enhance mouse repair, as well ameliorate cellular senescence restore dysfunctions. Notably, was remodeled reduced glycolysis enhanced OXPHOS after Met-EV treatment. We rescue senescence-induced mitochondria dysfunctions mitophagy suppressions, indicating the role of remodeling mitochondrial functions via production results reveal mechanism SnCs rejuvenation by suggest disturbed metabolism, be a potential target facilitating

Язык: Английский

---

Targeting Senescent Alveolar Epithelial Cells Using Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles To Treat Pulmonary Fibrosis

ACS Nano, Год журнала: 2024, Номер 18(9), С. 7046 - 7063

Опубликована: Фев. 21, 2024

Type 2 alveolar epithelial cell (AEC2) senescence is crucial to the pathogenesis of pulmonary fibrosis (PF). The nicotinamide adenine dinucleotide (NAD

Язык: Английский

---

Apoptotic vesicles are required to repair DNA damage and suppress premature cellular senescence

Journal of Extracellular Vesicles, Год журнала: 2024, Номер 13(4)

Опубликована: Апрель 1, 2024

It is well known that DNA damage can cause apoptosis. However, whether apoptosis and its metabolites contribute to repair largely unknown. In this study, we found apoptosis-deficient Fas

Язык: Английский

---

DeepDrug as an expert guided and AI driven drug repurposing methodology for selecting the lead combination of drugs for Alzheimer’s disease

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 15, 2025

Язык: Английский

---

Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 12, 2025

Senescent mandibular bone repair poses a formidable challenge without completely satisfactory strategy. Endogenous cell recruitment and osteogenic differentiation are two sequential stages in regeneration, disruptions these processes present significant obstacles to senescent repair. To address issues, engineered extracellular vesicles (EV) with stem functions were developed. This study demonstrated that Apt19s-engineered (Apt19s-EV) recognize recruit marrow mesenchymal cells derived from old rats (O-BMSCs) specifically effectively. MiR-376b-5p, identified by RNA sequencing transfection, was significantly decreased O-BMSCs, it selected construct miR-376b-5p-engineered (376b-EV). 376b-EV could promote osteogenesis alleviate senescence of O-BMSCs targeting Camsap1. combine the advantages Apt19s miR-376b-5p, dual (Apt-376b-EV) comprising both miR-376b-5p modifications constructed. further validate its function, Gelatin methacryloyl (GelMA) hydrogel used as carrier Apt-376b-EV@GelMA delivery system. The vitro results have sequentially. Notably, vivo also showed sequentially endogenous enhance new formation fracture critical-sized defect models. In summary, vesicles, Apt-376b-EV, offer an appealing solution for recruiting promoting microenvironment, which may broaden clinical applications EV provide valuable strategies treating bone-related diseases future work.

Язык: Английский

---