Causal functional maps of brain rhythms in working memory

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(14)

Опубликована: Март 27, 2024

Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite plethora of correlative neuroimaging evidence regarding architecture, our understanding critical hubs causally controlling overall performance incomplete. Causal interpretation requires testing following safe, temporal, and controllable neuromodulation specific nodes. Such experiments became available in healthy humans with advance transcranial alternating current stimulation (tACS). Here, we synthesize findings 28 placebo-controlled studies (in total, 1,057 participants) applied frequency-specific noninvasive neural oscillations examined neurotypical adults. We use computational meta-modeling method to simulate each intervention realistic virtual brains test reported behavioral outcomes against stimulation-induced electric fields different brain Our results show stimulating anterior frontal medial temporal theta occipitoparietal gamma rhythms leads significant dose-dependent improvement task performance. Conversely, prefrontal modulation detrimental Moreover, found distinct spatial expression subbands, where changes followed orbitofrontal high-theta low-theta modulation. Finally, all these are driven by accuracy rather than processing time measures. These provide fresh view mechanisms, complementary research, propose hypothesis-driven targets for clinical treatment deficits.

Язык: Английский

---

Advances in Non-Invasive Neuromodulation Techniques for Improving Cognitive Function: A Review

Brain Sciences, Год журнала: 2024, Номер 14(4), С. 354 - 354

Опубликована: Апрель 1, 2024

Non-invasive neuromodulation techniques are widely utilized to study and improve cognitive function, with the aim of modulating different processes. For workers performing high-intensity mental physical tasks, extreme fatigue may not only affect their working efficiency but also lead decline or impairment, which, in turn, poses a serious threat health. The use non-invasive has important research value for improving enhancing function. In this paper, we review status, existing problems, future prospects transcranial direct current stimulation (tDCS), alternating (tACS), magnetic (TMS), transcutaneous acupoint (TAS), which most studied methods enhance cognition. findings presented paper will be great reference in-depth field

Язык: Английский

---

Traumatic Brain Injury and Neuromodulation Techniques in Rehabilitation: A Scoping Review

Biomedicines, Год журнала: 2024, Номер 12(2), С. 438 - 438

Опубликована: Фев. 16, 2024

Background and Objectives: Traumatic Brain Injury (TBI) is a condition in which an external force, usually violent blow to the head, causes functional impairment brain. Neuromodulation techniques are thought restore altered function brain, resulting improved reduced symptoms. stimulation can alter firing of neurons, boost synaptic strength, neurotransmitters excitotoxicity, modify connections their neural networks. All these potential effects on brain activity. Accordingly, this promising therapy for TBI. These flexible because they target different areas vary frequency amplitude. This review aims investigate recent literature about neuromodulation used rehabilitation TBI patients. Materials Methods: The identification studies was made possible by conducting online searches PubMed, Web Science, Cochrane, Embase, Scopus databases. Studies published between 2013 2023 were selected. has been registered OSF (JEP3S). Results: We have found that improve process patients several ways. Transcranial Magnetic Stimulation (TMS) cognitive functions such as recall ability, substrates, overall performance neuropsychological tests. Repetitive TMS increase many but not all patients, those with chronic diffuse axonal damage.Conclusions: demonstrated instruments field, including affected efficacy significant impact lives outcomes

Язык: Английский

---

Effect of a single nonpharmacological intervention on cognitive functioning in older adults with mild-to-moderate Alzheimer's disease: A meta-analysis of randomized controlled trials

The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер unknown, С. 100050 - 100050

Опубликована: Янв. 1, 2025

Язык: Английский

---

Prefrontal theta—gamma transcranial alternating current stimulation improves non-declarative visuomotor learning in older adults

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 29, 2024

Abstract The rise in the global population of older adults underscores significance to investigate age-related cognitive disorders and develop early treatment modalities. Previous research suggests that non-invasive transcranial Alternating Current Stimulation (tACS) can moderately improve decline adults. However, non-declarative cognition has received relatively less attention. This study investigates whether repeated (16-day) bilateral theta—gamma cross-frequency tACS targeting Dorsolateral Prefrontal Cortex (DLPFC) enhances memory. Computerized training was applied alongside stimulation control for state-of-the-brain. Serial Reaction Time (ASRT) task employed assess functions such as visuomotor skill probabilistic sequence learning. Results from 35 participants aged 55–82 indicated active led more substantial improvements skills immediately after treatment, which persisted 3 months later, compared sham tACS. Treatment benefit pronounced younger age those with pre-existing decline. neither intervention group exhibited modulation These results suggest selectively distinct aspects when DLPFC. Our findings highlight therapeutic potential addressing deficits learning retaining general skills, could have a positive impact on quality life cognitively impaired individuals by preserving independence daily activities.

Язык: Английский

---

Frontoparietal theta stimulation causally links working memory with impulsive decision making

Cortex, Год журнала: 2025, Номер 185, С. 240 - 249

Опубликована: Март 6, 2025

Delaying gratification in value-based decision making is canonically related to activation the dorsolateral prefrontal cortex (dlPFC), but past research neglected that dlPFC part of a larger frontoparietal network. It therefore unknown whether causally implements delay concert with posterior parts network rather than isolation. Here, we addressed this gap by testing effects theta synchronization and desynchronization on impulsive using transcranial alternating current stimulation (tACS). Healthy participants performed an intertemporal choice task 3-back working memory while left frontal parietal cortices were stimulated 5 Hz frequency at in-phase (synchronization), anti-phase (desynchronization), or sham tACS. We found tACS improve performance, was associated more choices stronger hyperbolic discounting future rewards. Overall, our findings suggest future-oriented might rely synchronous memory.

Язык: Английский

---

Transcranial alternating current stimulation for schizophrenia: a systematic review of randomized controlled studies

Frontiers in Psychiatry, Год журнала: 2024, Номер 14

Опубликована: Янв. 11, 2024

Background In randomized clinical trials (RCTs) investigating the application of transcranial alternating current stimulation (tACS) in schizophrenia, inconsistent results have been reported. The purpose this exploratory systematic review RCTs was to evaluate tACS as an adjunct treatment for patients with schizophrenia based on its therapeutic effects, tolerability, and safety. Methods Our analysis included that evaluated adjunctive tACS’ effectiveness, safety patients. Three independent authors extracted data synthesized it using RevMan 5.3 software. Results involving 76 were encompassed analysis, 40 participants receiving active 36 sham tACS. study revealed a significant superiority over improving total psychopathology (standardized mean difference [SMD] = −0.61, 95% confidence interval [CI]: −1.12, −0.10; I 2 16%, p 0.02) negative (SMD −0.65, CI: −1.11, −0.18; 0%, 0.007) schizophrenia. two groups, however, showed no differences positive psychopathology, general or auditory hallucinations (all > 0.05). Two examined neurocognitive effects tACS, yielding varied findings. Both groups demonstrated similar rates discontinuation due any reason adverse events Conclusion Adjunctive is promising viable approach mitigating individuals diagnosed However, gain more comprehensive understanding tACS’s imperative conduct extensive, meticulously planned, well-documented RCTs.

Язык: Английский

---

The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial

Trials, Год журнала: 2024, Номер 25(1)

Опубликована: Фев. 23, 2024

Abstract Background The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia mild cognitive impairment (MCI). latter can be considered a prodromal phase some dementias critical stage for interventions to postpone functionality. Working memory (WM) is pivotal function, representing fundamental element executive functions. This project proposes an intervention protocol enhance WM in these users, combining training with transcranial electrical stimulation alternating current (tACS). technique been suggested neuronal plasticity needed processes involving oscillatory patterns. stands benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost patients neurodegenerative diseases. Methods study IIb randomised, double-blind clinical trial 3-month follow-up period. participants will 62 diagnosed MCI, aged over 60, Valparaíso, Chile. Participants receive twelve sessions tACS. either or placebo eight out sessions. Sessions occur twice weekly 6 weeks. primary outcomes electroencephalographic measurements through prefrontal theta activity, while secondary effects assessments WM. evaluated before, immediately after, 3 months after end intervention. Discussion add empirical evidence about benefits feasibility that combines non-invasive brain stimulation. objective contribute tools optimal treatment MCI. To capacity, functionality, obtain better quality life. Trial registration ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered 15 September 2023.

Язык: Английский

---

Boosting working memory in the elderly: driving prefrontal theta–gamma coupling via repeated neuromodulation

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Июль 12, 2024

Abstract The escalating global burden of age-related neurodegenerative diseases and associated healthcare costs necessitates innovative interventions to stabilize or enhance cognitive functions. Deficits in working memory (WM) are linked alterations prefrontal theta–gamma cross-frequency coupling. Low-intensity transcranial alternating current stimulation (tACS) has emerged as a non-invasive, low-cost approach capable modulating ongoing oscillations targeted brain areas through entrainment. This study investigates the impact multi-session peak-coupled tACS administered dorsolateral cortex (DLPFC) on WM performance older adults. In randomized, sham-controlled, triple-blinded design, 77 participants underwent 16 sessions over six weeks while performing n -back tasks. Signal detection measures revealed increased 2-back sensitivity robust modulations response bias, indicating improved decision-making adaptations, respectively. No effects were observed 1-back condition, emphasizing dependencies load. Repeated reinforces behavioral changes, indicated by increasing effect sizes. supports prior research correlating coupling with processes provides unique insights into neurocognitive benefits repeated intervention. well-tolerated highly effective intervention among elderly underscores its therapeutic potential vulnerable populations.

Язык: Английский

---

Lesion network guided delta frequency neuromodulation improves cognition in patients with psychosis spectrum disorders: A pilot study

Asian Journal of Psychiatry, Год журнала: 2023, Номер 92, С. 103887 - 103887

Опубликована: Дек. 26, 2023

Язык: Английский

---