The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial DOI Creative Commons
Alejandra Figueroa-Vargas, Begoña Góngora Costa, Maria Francisca Alonso‐Sánchez

et al.

Trials, Journal Year: 2024, Volume and Issue: 25(1)

Published: Feb. 23, 2024

Abstract Background The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia mild cognitive impairment (MCI). latter can be considered a prodromal phase some dementias critical stage for interventions to postpone functionality. Working memory (WM) is pivotal function, representing fundamental element executive functions. This project proposes an intervention protocol enhance WM in these users, combining training with transcranial electrical stimulation alternating current (tACS). technique been suggested neuronal plasticity needed processes involving oscillatory patterns. stands benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost patients neurodegenerative diseases. Methods study IIb randomised, double-blind clinical trial 3-month follow-up period. participants will 62 diagnosed MCI, aged over 60, Valparaíso, Chile. Participants receive twelve sessions tACS. either or placebo eight out sessions. Sessions occur twice weekly 6 weeks. primary outcomes electroencephalographic measurements through prefrontal theta activity, while secondary effects assessments WM. evaluated before, immediately after, 3 months after end intervention. Discussion add empirical evidence about benefits feasibility that combines non-invasive brain stimulation. objective contribute tools optimal treatment MCI. To capacity, functionality, obtain better quality life. Trial registration ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered 15 September 2023.

Language: Английский

Causal functional maps of brain rhythms in working memory DOI Creative Commons
Miles Wischnewski, Taylor Berger, Alexander Opitz

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(14)

Published: March 27, 2024

Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite plethora of correlative neuroimaging evidence regarding architecture, our understanding critical hubs causally controlling overall performance incomplete. Causal interpretation requires testing following safe, temporal, and controllable neuromodulation specific nodes. Such experiments became available in healthy humans with advance transcranial alternating current stimulation (tACS). Here, we synthesize findings 28 placebo-controlled studies (in total, 1,057 participants) applied frequency-specific noninvasive neural oscillations examined neurotypical adults. We use computational meta-modeling method to simulate each intervention realistic virtual brains test reported behavioral outcomes against stimulation-induced electric fields different brain Our results show stimulating anterior frontal medial temporal theta occipitoparietal gamma rhythms leads significant dose-dependent improvement task performance. Conversely, prefrontal modulation detrimental Moreover, found distinct spatial expression subbands, where changes followed orbitofrontal high-theta low-theta modulation. Finally, all these are driven by accuracy rather than processing time measures. These provide fresh view mechanisms, complementary research, propose hypothesis-driven targets for clinical treatment deficits.

Language: Английский

Citations

12
Traumatic Brain Injury and Neuromodulation Techniques in Rehabilitation: A Scoping Review DOI Creative Commons

Andrea Calderone,

Davide Cardile, Antonio Gangemi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 438 - 438

Published: Feb. 16, 2024

Background and Objectives: Traumatic Brain Injury (TBI) is a condition in which an external force, usually violent blow to the head, causes functional impairment brain. Neuromodulation techniques are thought restore altered function brain, resulting improved reduced symptoms. stimulation can alter firing of neurons, boost synaptic strength, neurotransmitters excitotoxicity, modify connections their neural networks. All these potential effects on brain activity. Accordingly, this promising therapy for TBI. These flexible because they target different areas vary frequency amplitude. This review aims investigate recent literature about neuromodulation used rehabilitation TBI patients. Materials Methods: The identification studies was made possible by conducting online searches PubMed, Web Science, Cochrane, Embase, Scopus databases. Studies published between 2013 2023 were selected. has been registered OSF (JEP3S). Results: We have found that improve process patients several ways. Transcranial Magnetic Stimulation (TMS) cognitive functions such as recall ability, substrates, overall performance neuropsychological tests. Repetitive TMS increase many but not all patients, those with chronic diffuse axonal damage.Conclusions: demonstrated instruments field, including affected efficacy significant impact lives outcomes

Language: Английский

Citations

11
Advances in Non-Invasive Neuromodulation Techniques for Improving Cognitive Function: A Review DOI Creative Commons
Ruijuan Chen, Lengjie Huang, Rui Wang

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 354 - 354

Published: April 1, 2024

Non-invasive neuromodulation techniques are widely utilized to study and improve cognitive function, with the aim of modulating different processes. For workers performing high-intensity mental physical tasks, extreme fatigue may not only affect their working efficiency but also lead decline or impairment, which, in turn, poses a serious threat health. The use non-invasive has important research value for improving enhancing function. In this paper, we review status, existing problems, future prospects transcranial direct current stimulation (tDCS), alternating (tACS), magnetic (TMS), transcutaneous acupoint (TAS), which most studied methods enhance cognition. findings presented paper will be great reference in-depth field

Language: Английский

Citations

11
Frontoparietal theta stimulation causally links working memory with impulsive decision making DOI Creative Commons
Georgia Eleni Kapetaniou, Gizem Vural, Alexander Soutschek

et al.

Cortex, Journal Year: 2025, Volume and Issue: 185, P. 240 - 249

Published: March 6, 2025

Delaying gratification in value-based decision making is canonically related to activation the dorsolateral prefrontal cortex (dlPFC), but past research neglected that dlPFC part of a larger frontoparietal network. It therefore unknown whether causally implements delay concert with posterior parts network rather than isolation. Here, we addressed this gap by testing effects theta synchronization and desynchronization on impulsive using transcranial alternating current stimulation (tACS). Healthy participants performed an intertemporal choice task 3-back working memory while left frontal parietal cortices were stimulated 5 Hz frequency at in-phase (synchronization), anti-phase (desynchronization), or sham tACS. We found tACS improve performance, was associated more choices stronger hyperbolic discounting future rewards. Overall, our findings suggest future-oriented might rely synchronous memory.

Language: Английский

Citations

1
Prefrontal theta—gamma transcranial alternating current stimulation improves non-declarative visuomotor learning in older adults DOI Creative Commons
Lukas Diedrich,

Hannah I. Kolhoff,

Ivan Chakalov

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 29, 2024

Abstract The rise in the global population of older adults underscores significance to investigate age-related cognitive disorders and develop early treatment modalities. Previous research suggests that non-invasive transcranial Alternating Current Stimulation (tACS) can moderately improve decline adults. However, non-declarative cognition has received relatively less attention. This study investigates whether repeated (16-day) bilateral theta—gamma cross-frequency tACS targeting Dorsolateral Prefrontal Cortex (DLPFC) enhances memory. Computerized training was applied alongside stimulation control for state-of-the-brain. Serial Reaction Time (ASRT) task employed assess functions such as visuomotor skill probabilistic sequence learning. Results from 35 participants aged 55–82 indicated active led more substantial improvements skills immediately after treatment, which persisted 3 months later, compared sham tACS. Treatment benefit pronounced younger age those with pre-existing decline. neither intervention group exhibited modulation These results suggest selectively distinct aspects when DLPFC. Our findings highlight therapeutic potential addressing deficits learning retaining general skills, could have a positive impact on quality life cognitively impaired individuals by preserving independence daily activities.

Language: Английский

Citations

7
Transcranial alternating current stimulation for schizophrenia: a systematic review of randomized controlled studies DOI Creative Commons
Xin Wei,

Zhan-Ming Shi,

Xian-Jun Lan

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

Background In randomized clinical trials (RCTs) investigating the application of transcranial alternating current stimulation (tACS) in schizophrenia, inconsistent results have been reported. The purpose this exploratory systematic review RCTs was to evaluate tACS as an adjunct treatment for patients with schizophrenia based on its therapeutic effects, tolerability, and safety. Methods Our analysis included that evaluated adjunctive tACS’ effectiveness, safety patients. Three independent authors extracted data synthesized it using RevMan 5.3 software. Results involving 76 were encompassed analysis, 40 participants receiving active 36 sham tACS. study revealed a significant superiority over improving total psychopathology (standardized mean difference [SMD] = −0.61, 95% confidence interval [CI]: −1.12, −0.10; I 2 16%, p 0.02) negative (SMD −0.65, CI: −1.11, −0.18; 0%, 0.007) schizophrenia. two groups, however, showed no differences positive psychopathology, general or auditory hallucinations (all > 0.05). Two examined neurocognitive effects tACS, yielding varied findings. Both groups demonstrated similar rates discontinuation due any reason adverse events Conclusion Adjunctive is promising viable approach mitigating individuals diagnosed However, gain more comprehensive understanding tACS’s imperative conduct extensive, meticulously planned, well-documented RCTs.

Language: Английский

Citations

6
Effect of a single nonpharmacological intervention on cognitive functioning in older adults with mild-to-moderate Alzheimer's disease: A meta-analysis of randomized controlled trials DOI Creative Commons
Kejin Chen,

Zhao Xiao-yan,

Jingwen Zhou

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100050 - 100050

Published: Jan. 1, 2025

Language: Английский

Citations

0
High intensity transcranial altering current stimulation for cognitive dysfunction in schizophrenia: a pilot trial DOI Creative Commons
Zifan You,

Zhangyin He,

Ling Zou

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Modulation of vigilance/alertness using beta (30 Hz) transcranial alternating current stimulation DOI Creative Commons
Zhangjie Chu, Rui Wang, Tianyi Zhou

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 13, 2025

Vigilance refers to the ability maintain alertness and sustain attention for prolonged periods detect respond subtle changes in environment. Previous research has explored use of transcranial alternating current stimulation (tACS) modulate brain oscillations enhance vigilance/alertness. In this study, we explore modulation effects different parameters on using an open-source dataset. The dataset includes within participant application High-Definition tES (HD-tES) types, targeting two cortical regions (frontal, motor) with one waveforms (30 Hz); combining human-participant high-density electroencephalography (EEG) continuous behavioral metrics. We only analyzed task performance data assess how vigilant states are acutely altered by specific types. Our findings indicate that (1) Both online offline tACS improve vigilance performance; (2) have greater effect than tACS; (3) frontal region stimulating motor region. These results align view theoretical accounts oscillatory nature contribute groundwork closed-loop interventions counteracting decrements.

Language: Английский

Citations

0
Non-invasive Brain Stimulation Techniques DOI
Ujwal Chaudhary

Published: Jan. 1, 2025

Citations

0