Biomedical Chromatography,
Год журнала:
2024,
Номер
38(11)
Опубликована: Авг. 20, 2024
Arisaema
cum
bile
(known
as
Dan
Nanxing
in
Chinese,
DNX)
is
a
herbal
medicine
used
for
treating
febrile
seizure
(FS),
which
commonly
prepared
by
using
Arisaematis
Rhizoma
and
animal
bile.
This
study
was
designed
to
explore
the
optimal
processing
time
of
DNX
its
potential
mechanism
on
anti-FS
effect.
A
total
17
volatile
organic
compounds
(VOCs)
were
characteristic
ones
distinguish
different
fermentation
stages
gas
chromatography-ion
mobility
spectrometry
(GC-IMS),
such
2-heptanone
monomer,
heptanal
monomer.
with
3
months
had
an
obvious
pattern
VOCs
others,
could
be
regarded
time.
The
Enterococcus
Staphylococcus
might
core
bacteria
production
VOCs.
Additionally,
(2.8
g/kg,
p.o.)
reversed
hot
water
bath-induced
FSs
rats,
indicated
increased
latency
decreased
duration
It
also
prevented
hippocampal
neuronal
loss,
GABAAR,
GRIA1
expression.
At
genus
level,
relative
abundance
Akkermansia
enriched
after
treatment.
These
findings
suggested
that
process
DNX,
possess
effect
through
regulating
neurotransmitter
disorder
gut
microbiota.
Nature Microbiology,
Год журнала:
2024,
Номер
9(9), С. 2244 - 2261
Опубликована: Июль 15, 2024
Gut
bacteria
are
linked
to
neurodegenerative
diseases
but
the
risk
factors
beyond
microbiota
composition
limited.
Here
we
used
a
pre-clinical
model
of
multiple
sclerosis
(MS),
experimental
autoimmune
encephalomyelitis
(EAE),
identify
microbial
factors.
Mice
with
different
genotypes
and
complex
microbiotas
or
six
combinations
synthetic
human
were
analysed,
resulting
in
varying
probabilities
severe
neuroinflammation.
However,
presence
relative
abundances
suspected
failed
predict
disease
severity.
Akkermansia
muciniphila,
often
associated
MS,
exhibited
variable
associations
EAE
severity
depending
on
background
microbiota.
Significant
inter-individual
course
variations
observed
among
mice
harbouring
same
Evaluation
functional
characteristics
host
immune
responses
demonstrated
that
immunoglobulin
A
coating
index
certain
before
onset
is
robust
individualized
predictor
development.
Our
study
highlights
need
consider
community
networks
host-specific
bidirectional
interactions
when
aiming
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 14, 2025
Hepatocellular
carcinoma
(HCC)
is
the
most
frequently
occurring
type
of
liver
tumor
and
considered
one
common
primary
malignant
neoplasms.
The
prognosis
for
HCC
dismal
because
its
complicated
etiology
high
level
medication
resistance.
Immunotherapy
presently
regarded
as
effective
therapeutic
options
HCC;
nevertheless,
disturbance
intestinal
flora,
immunotherapy
shows
low
antitumor
efficacy.
An
increasing
body
research
indicates
that
particularly
Akkermansia
muciniphila
(
A.
),
vital
treatment
tumors.
Studies
have
demonstrated
diminished
effectiveness
in
cancer
patients
associated
with
a
reduction
levels,
suggesting
levels
significantly
enhance
efficacy
immunotherapy.
functions
gut
probiotic
can
treat
prevent
wide
range
illnesses,
including
cancer.
Consequently,
preserving
abundance
enough
to
lower
danger
developing
disorders.
In
this
review,
we
critically
evaluate
current
on
,
focus
biological
properties
functions.
different
illnesses
treats
were
then
discussed,
way
it
works
This
review
aims
give
novel
plan
well
theoretical
foundation
improving
Immunological Reviews,
Год журнала:
2024,
Номер
325(1), С. 131 - 151
Опубликована: Май 8, 2024
Multiple
sclerosis
(MS)
is
an
autoimmune
disease
of
the
central
nervous
system,
affecting
nearly
2
million
people
worldwide.
The
etiology
MS
multifactorial:
Approximately
30%
risk
genetic,
which
implies
that
remaining
~70%
environmental,
with
a
number
factors
proposed.
One
recently
implicated
factor
for
composition
gut
microbiome.
Numerous
case-control
studies
have
identified
changes
in
microbiota
(pwMS)
compared
healthy
control
individuals,
and
more
recent
animal
models
begun
to
identify
causative
microbes
underlying
mechanisms.
Here,
we
review
some
these
mechanisms,
specific
focus
on
role
host
genetic
variation,
dietary
inputs,
microbial
metabolism,
particular
emphasis
short-chain
fatty
acid
tryptophan
metabolism.
We
put
forward
model
where,
individual
genetically
susceptible
MS,
diet
can
synergize
as
potent
environmental
modifiers
possibly
progression,
diet-dependent
metabolites
serving
key
mechanism.
also
propose
taxa
may
divergent
effects
individuals
carrying
distinct
variants
alleles
or
other
polymorphisms,
consequence
gene-by-gut
interactions.
Finally,
taxa,
especially
those
exert
their
through
metabolites,
are
highly
dependent
intake.
What
emerges
complex
multifaceted
interaction
has
been
challenging
disentangle
human
studies,
contributing
divergence
findings
across
heterogeneous
cohorts
differing
geography,
preferences,
genetics.
Nonetheless,
this
provides
individualized,
yet
tractable,
how
regulate
susceptibility
potentially
progression
disease.
Thus,
conclude
prophylactic
therapeutic
modulation
microbiome
prevent
treat
will
require
careful
personalized
consideration
genetics,
baseline
composition,
inputs.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5377 - 5377
Опубликована: Май 15, 2024
In
recent
years,
there
has
been
a
growing
interest
in
the
concept
of
“gut–brain
axis”.
addition
to
well-studied
diseases
associated
with
an
imbalance
gut
microbiota,
such
as
cancer,
chronic
inflammation,
and
cardiovascular
diseases,
research
is
now
exploring
potential
role
microbial
dysbiosis
onset
development
brain-related
diseases.
When
function
intestinal
barrier
altered
by
dysbiosis,
aberrant
immune
system
response
interacts
nervous
system,
leading
state
“neuroinflammation”.
The
microbiota–brain
axis
mediated
inflammatory
immunological
mechanisms,
neurotransmitters,
neuroendocrine
pathways.
This
narrative
review
aims
illustrate
molecular
basis
neuroinflammation
elaborate
on
gut–brain
virtue
analyzing
various
metabolites
produced
microbiome
how
they
might
impact
system.
Additionally,
current
will
highlight
sex
influences
these
mechanisms.
fact,
hormones
brain–gut
microbiota
at
different
levels,
central
enteric
one,
enteroendocrine
cells.
A
deeper
understanding
human
health
disease
crucial
guide
diagnoses,
treatments,
preventive
interventions.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 3, 2025
Background
Akkermansia
muciniphila
,
as
a
probiotic,
is
negatively
linked
to
IBD,
obesity,
and
T2DM.
The
aim
of
this
study
was
comprehensively
assess
the
research
status
over
past
decade
explore
relationships
between
bacterium
various
health-related
aspects.
Methods
Tools
VOSviewer,
Bibliometrix,
CiteSpace
were
used
analyze
aspects
including
publication
metrics,
contributors,
institutions,
geography,
journals,
funding,
keywords.
Results
Over
decade,
on
has
demonstrated
consistent
annual
growth
in
number
publications,
with
notable
peak
2021.
China
led
totaling
151,
whereas
United
States
exhibited
higher
centrality
value.
Among
820
institutions
involved
research,
University
California
(from
States)
Chinese
Academy
Sciences
China)
occupied
central
positions.
Willem
M.
De
Vos
ranked
at
top,
12
publications
1,108
citations.
journal
GUT,
which
had
5,125
citations
an
Impact
Factor
23.0
2024,
most
highly
cited.
cited
articles
deepened
understanding
bacterium’s
impact
human
health,
spanning
from
basic
translational
medicine.
Thirty-nine
high-frequency
keywords
grouped
into
five
clusters,
illustrating
’s
associations
metabolic
diseases,
chronic
kidney
disease,
gut-brain
axis,
intestinal
inflammation,
Bacteroidetes-Firmicutes
shifts.
Conclusion
Given
anti-inflammatory
gut-barrier-strengthening
properties,
it
holds
promise
therapeutic
for
disorders,
inflammatory
conditions.
Therefore,
future
should
its
potential
further
by
conducting
clinical
trials,
elucidating
mechanisms
action,
investigating
efficacy
safety
diverse
patient
populations.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 18
Опубликована: Окт. 16, 2024
Akkermansia
muciniphila
(A.
muciniphila)
has
gained
recognition
as
a
pioneering
probiotic,
exhibiting
considerable
potential
to
enhance
immune
conditions
across
both
humans
and
animals.
The
health
benefits
of
A.
are
attributed
its
various
components,
including
outer
membrane
proteins
(PilQ
Amuc_1100),
secreted
(P9
AmTARS),
extracellular
vesicles,
metabolites
such
SCFAs,
ornithine
lipids,
γ-aminobutyric
acid,
cobalamin,
inosine.
dynamic
control
the
mucus
layer
by
plays
crucial
role
in
regulating
intestinal
mucosal
immunity.
Furthermore,
modulates
function
interacting
with
macrophages,
dendritic
cells,
T
lymphocytes,
Paneth
cells.
Increasing
abundance
gut
through
nutritional
strategies
represents
safe
effective
means
augment
function.
Various
polyphenols,
oligosaccharides,
polysaccharides
have
been
shown
elevate
levels
this
bacterium,
thereby
contributing
favorable
immunoregulatory
outcomes.
This
paper
delves
into
latest
research
advancements
related
probiotic
mechanisms
provides
an
overview
current
understanding
how
responds
nutrients.
These
insights
offer
theoretical
foundation
for
utilization
immunoregulation.
