Postharvest Biology and Technology, Год журнала: 2023, Номер 209, С. 112679 - 112679
Опубликована: Ноя. 30, 2023
Язык: Английский
Aging and Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The characteristics of human aging manifest in tissue and organ function decline, heightening susceptibility to age-related ailments, thereby presenting novel challenges fostering sustaining healthy longevity. In recent years, an abundance research on has surfaced. Intriguingly, evidence suggests a pervasive correlation among gut microbiota, bodily functions, chronic diseases. From infancy later stages adulthood, individuals witness dynamic shifts microbiota composition. This microbial community is associated with deterioration (e.g., brain, bones, muscles, immune system, vascular system) heightened risk Thus, we present narrative review the microbiome both unhealthy contexts. Additionally, explore potential for adjustments physical health based analysis how targeting can potentially slow down process.
Язык: Английский
Процитировано
3
Cells, Год журнала: 2024, Номер 13(9), С. 770 - 770
Опубликована: Апрель 30, 2024
Parkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of central nervous system. Clinically, PD characterized a movement disorder, exhibiting an incidence and mortality rate that increasing faster than any other neurological condition. In recent years, there has been growing interest concerning role gut microbiota in etiology pathophysiology PD. The establishment brain–gut axis now real, with evidence denoting bidirectional communication between brain through metabolic, immune, neuronal, endocrine mechanisms pathways. Among these, vagus nerve represents direct form gut. Given potential interactions bacteria drugs, it observed therapies for can have impact on composition microbiota. Therefore, scope present review, we will discuss current understanding whether this may be new paradigm treating devastating disease.
Язык: Английский
Процитировано
3
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(5), С. 4803 - 4814
Опубликована: Май 15, 2024
Over the last decades, analysis of complex microbial communities by high-throughput sequencing marker gene amplicons has become routine work for many research groups. However, main challenges faced scientists who want to make use generated datasets are lack expertise select a suitable pipeline and need bioinformatics or programming skills apply it. Here, we present MetaXplore, an interactive, user-friendly platform that enables discovery visualization amplicon data. Currently, it provides set well-documented choices downstream analysis, including alpha beta diversity taxonomic composition, differential abundance identification core microbiome within population, biomarker analysis. These features presented in format facilitates easy customization generation publication-quality graphics. MetaXplore is implemented entirely R language using Shiny framework. It can be easily used locally on any system with installed, Windows, Mac OS, most Linux distributions, remotely via web server without bioinformatic expertise. also as framework advanced users modify expand tool.
Язык: Английский
Процитировано
3
Microbial Ecology, Год журнала: 2023, Номер 86(3), С. 1487 - 1498
Опубликована: Апрель 26, 2023
Язык: Английский
Процитировано
9
FEMS Microbiology Ecology, Год журнала: 2023, Номер 99(9)
Опубликована: Авг. 22, 2023
Abstract Despite growing interest in fungal necromass decomposition due to its importance soil carbon retention, whether a consistent group of microorganisms is associated with decomposing remains unresolved. Here, we synthesize knowledge on the composition bacterial and communities present from variety species, geographic locations, habitats, incubation times. We found that there core both genera (i.e. necrobiome), although specific size depended definition. Based metric included microbial frequency abundance, demonstrate taxonomically functionally diverse, including copiotrophs oligotrophs as well saprotrophs, ectomycorrhizal fungi, animal parasites. also show necrobiome notably dynamic over time, many having associations early, middle, or late stages decomposition. While this study establishes existence necrobiome, advocate profiling decomposer tropical environments other terrestrial biomes beyond forests needed fill key gaps regarding global nature necrobiome.
Язык: Английский
Процитировано
8
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Фев. 26, 2024
Abstract Gut microbiota, or the collection of diverse microorganisms in a specific ecological niche, are known to significantly impact human health. Decreased gut microbiota production short-chain fatty acids (SCFAs) has been implicated type 2 diabetes mellitus (T2DM) disease progression. Most microbiome studies focus on ethnic majorities. This study aims understand how differs between an majority (the Dutch) and minority South-Asian Surinamese (SAS)) group with lower higher prevalence T2DM, respectively. Microbiome data from Healthy Life Urban Setting (HELIUS) cohort were used. Two age- gender-matched groups compared: Dutch (n = 41) SAS 43). Microbial community compositions generated via DADA2. Metrics microbial diversity similarity computed. Biomarker analyses performed determine discriminating taxa. Bacterial co-occurrence networks constructed examine patterns. A tight cluster was observed women, which overlapped some microbiota. The contained more interconnected ecology, whereas network dispersed, i.e., fewer inter-taxonomic correlational relationships. Bacteroides caccae, Butyricicoccus, Alistipes putredinis, Coprococcus comes , Odoribacter splanchnicus, Lachnospira enriched gut. Haemophilus Bifidobacterium, Anaerostipes hadrus discriminated All but certain strains produce SCFAs. distinguished by diverse, differentially abundant SCFA-producing taxa significant cooperation. dynamic ecology not detected SAS. Among several potential biomarkers, parainfluenzae likely best characterizes group, is predisposed T2DM. T2DM may be associated dysbiosis observed.
Язык: Английский
Процитировано
2
Опубликована: Апрель 19, 2024
Parkinson's disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of central nervous system. Clinically, PD characterized a movement disorder, exhibiting an incidence and mortality rate that increasing faster than any other neurological condition. In recent years, there has been growing interest concerning role gut microbiome in etiology pathophysiology PD. The establishment brain-gut axis now real, with evidence denoting bidirectional communication between brain microbiota through metabolic, immune, neuronal, endocrine mechanisms pathways. Among these, vagus nerve represents direct form gut. Given potential interactions bacteria drugs, it observed therapies for can have impact on composition microbiome. Therefore, scope present review, we will discuss current understanding whether this may be new paradigm treating devastating disease.
Язык: Английский
Процитировано
2
Environmental Microbiology, Год журнала: 2024, Номер 26(5)
Опубликована: Май 1, 2024
Abstract The degradation of freshwater systems by salt pollution is a threat to global resources. Salinization commonly identified increased specific conductance (conductivity), proxy for concentrations. However, conductivity fails account the diversity salts entering freshwaters and potential implications this has on microbial communities functions. We tested 4 types pollution—MgCl 2 , MgSO NaCl, Na SO —on bacterial taxonomic functional α‐, β‐diversity originating from streams in two distinct localities (Nebraska [NE] Ohio [OH], USA). Community responses depended site origin, with NE OH exhibiting more pronounced decreases community response MgCl than other amendments. A closer examination metrics suggests that core features are resistant induced stress marginal at both population level likely exhibit significant structural shifts based specificity. lack uniformity highlights need consider compositional complexities salinization accurately identify ecological consequences instances pollution.
Язык: Английский
Процитировано
2
Environmental Science & Technology, Год журнала: 2024, Номер 58(37), С. 16475 - 16487
Опубликована: Сен. 5, 2024
Genome-resolved insights into the structure and function of drinking water microbiome can advance effective management quality. To enable this, we constructed curated thousands metagenome-assembled isolate genomes from distribution systems globally to develop a Drinking Water Genome Catalog (DWGC). The current DWGC disproportionately represents disinfected due paucity metagenomes nondisinfected systems. Using DWGC, identify core genera including genus (UBA4765) within order Rhizobiales that is frequently detected highly abundant in We demonstrate this has been widely but incorrectly classified previous amplicon sequencing-based investigations microbiome. Further, show single genome variant (genomovar) 75% included study. propose name for uncultured bacterium as "
Язык: Английский
Процитировано
2
Environmental Science & Technology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 11, 2024
As water reuse applications expand, there is a need for more comprehensive means to assess quality. Microbiome analysis could provide the ability supplement fecal indicators and pathogen profiling toward defining "healthy" drinking microbiota while also providing insight into impact of treatment distribution. Here, we utilized 16S rRNA gene amplicon sequencing identify signature features in composition across wide spectrum types (potable conventional, potable reuse, nonpotable reuse). A clear distinction was found as function intended use (e.g., vs nonpotable) very broad range U.S. systems at both point compliance (Betadisper
Язык: Английский
Процитировано
2