bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 24, 2023
RSV
and
SARS-CoV-2
are
prone
to
co-infection
with
other
respiratory
viruses.
In
this
study,
we
use
RSV/SARS-CoV-2
evaluate
changes
clinical
disease
viral
replication
in
vivo.
To
consider
the
severity
of
infection,
effect
sequential
impact
infection
timing,
mice
were
co-infected
varying
doses
timing.
Compared
a
single
or
SARS-CoV-2,
primary
followed
by
results
protection
from
SARS-CoV-2-induced
reduces
replication.
Co-infection
also
augmented
at
early
timepoints
only
low
dose.
Additionally,
led
improved
clearance
regardless
load.
However,
enhanced
while
protecting
RSV-induced
disease.
SARS-CoV-2/RSV
reduced
lung
tissue,
Collectively,
these
data
suggest
that
may
afford
enhancement
based
on
variation
order,
and/or
pediatric
population,
understanding
dynamics
will
be
critical
treat
patients
mitigate
outcomes.
Immunity Inflammation and Disease,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Background
Several
respiratory
viruses,
including
Severe
Acute
Respiratory
Syndrome‐Coronavirus‐2
(SARS‐CoV‐2),
suppress
nuclear
factor‐E2‐related
factor‐2
(NRF2)
antioxidant
response,
generating
oxidative
stress
conditions
to
its
advantage.
NRF2
has
also
been
reported
regulate
the
innate
immune
response
through
inhibition
of
interferon
(IFN)
pathway.
However,
modulation
in
younger
individuals
and
correlation
with
IFN
remain
be
elucidated.
Methods
The
redox‐related
genes
expression
was
examined
nasopharyngeal
swabs
from
children
attending
pediatric
hospital
for
SARS‐CoV‐2
molecular
testing.
Expression
levels
were
analyzed
by
stratifying
population
according
positivity,
age,
or
presence
symptoms.
results
correlated
Types
I
III
IFN‐stimulated
(ISGs).
Results
We
found
that
markedly
diminished
positive
patients
compared
negative.
Moreover,
it
higher
IFNα2
IFNλ3,
as
well
ISG15
ISG56.
Interestingly,
symptomatic
anosmia/ageusia
showed
pronounced
apurinic/apyrimidinic
endonuclease1/redox
factor
1
(APE1),
together
Type
IFNs,
ISG56,
inflammasome
component
NLRP3.
Conclusion
indicate
an
interdependence
between
pathway
IFN‐mediated
during
infection
young
subjects.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1098 - 1098
Опубликована: Янв. 27, 2025
This
article
reviews
the
synergistic
effects
of
antioxidant-enriched
functional
foods
and
exercise
in
improving
metabolic
health,
focusing
on
underlying
molecular
mechanisms.
The
review
incorporates
evidence
from
PubMed,
SCOPUS,
Web
Science,
PsycINFO,
reference
lists
relevant
up
to
20
December
2024,
highlighting
central
role
Nrf2
pathway.
As
a
critical
regulator
oxidative
stress
adaptation,
mediates
benefits
these
interventions.
presents
an
innovative
approach
understanding
regulation
inflammation,
its
potential
prevention
treatment
various
diseases,
including
cancer,
neurodegenerative
disorders,
cardiovascular
pulmonary
diabetes,
inflammatory
conditions,
ageing,
infections
such
as
COVID-19.
novelty
this
study
is
investigate
bioactive
compounds
found
(such
polyphenols,
flavonoids,
vitamins)
exercise-induced
activation
combined
reveals
their
improve
insulin
sensitivity
lipid
metabolism
reduce
offering
promising
strategy
for
management
chronic
diseases.
However,
there
are
significant
gaps
current
research,
particularly
regarding
mechanisms
interaction
between
diet,
physical
activity,
activation,
well
long-term
different
populations,
those
with
In
addition,
interactions
other
signalling
pathways,
AMPK,
NF-κB,
PI3K/Akt,
collective
contributions
health
explored.
Furthermore,
novel
biomarkers
presented
assess
impact
strategies,
NAD+/NADH
ratio,
GSH
markers
mitochondrial
health.
findings
provide
valuable
insights
into
how
integration
antioxidant-rich
diet
regular
can
by
activating
related
pathways
represent
strategies
disorders.
Further
studies
needed
fully
understand
therapeutic
interventions
diseases
stress,
disease,
cancer.
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 9, 2023
Abstract
According
to
a
paper
released
and
submitted
WHO
by
IARC
scientists,
there
would
be
905,700
new
cases
of
liver
cancer
diagnosed
globally
in
2020,
with
830,200
deaths
expected
as
direct
result.
Hepatitis
B
virus
(HBV)
hepatitis
C
(HCV),
D
(HDV)
all
play
critical
roles
the
pathogenesis
hepatocellular
carcinoma
(HCC),
despite
rising
prevalence
HCC
due
non-infectious
causes.
Liver
cirrhosis
are
devastating
consequences
HBV
HCV
infections,
which
widespread
worldwide.
Associated
high
mortality
rate,
these
infections
cause
about
1.3
million
annually
primary
globally.
In
addition
causing
insertional
mutations
viral
gene
integration,
epigenetic
alterations
inducing
chronic
immunological
dysfunction
methods
viruses
turn
hepatocytes
into
cancerous
ones.
While
expanding
our
knowledge
illness,
identifying
pathways
also
give
possibilities
for
novel
diagnostic
treatment
methods.
Nuclear
factor
erythroid
2-related
2
(NRF2)
activation
is
gaining
popularity
option
oxidative
stress
(OS),
inflammation,
metabolic
abnormalities.
Numerous
studies
have
shown
that
elevated
Nrf2
expression
linked
HCC,
providing
more
evidence
HCC.
This
aberrant
signaling
drives
cell
proliferation,
initiates
angiogenesis
invasion,
imparts
drug
resistance.
As
result,
this
master
regulator
may
promising
target
addition,
common
effect
contributes
pathogenesis,
development,
chronicity
infection.
However,
certain
suppress
activity,
helpful
maintaining
cellular
homeostasis.
paper,
we
discussed
influence
deregulation
on
life
cycle
associated
HCV.
We
summed
up
mechanisms
modulation
deregulated
viruses.
Moreover,
describe
molecular
mechanism
modulated
cancer,
stem
cells
(LCSCs),
caused
Frontiers in Molecular Biosciences,
Год журнала:
2023,
Номер
10
Опубликована: Июнь 1, 2023
The
emergence
and
re-emergence
of
viral
diseases,
which
cause
significant
global
mortality
morbidity,
are
the
major
concerns
this
decade.
Of
these,
current
research
is
focused
majorly
on
etiological
agent
COVID-19
pandemic,
SARS-CoV-2.
Understanding
host
response
metabolic
changes
during
infection
may
provide
better
therapeutic
targets
for
proper
management
pathophysiological
conditions
associated
with
SARS-CoV-2
infection.
We
have
achieved
control
over
most
emerging
diseases;
however,
a
lack
understanding
underlying
molecular
events
prevents
us
from
exploring
novel
targets,
leaving
forced
to
witness
re-emerging
infections.
usually
accompanied
by
oxidative
stress,
leads
an
overactive
immune
response,
release
inflammatory
cytokines,
increasing
lipid
production,
also
alterations
in
endothelial
mitochondrial
functions.
PI3K/Akt
signaling
pathway
confers
protection
against
injury
various
cell
survival
mechanisms
including
Nrf2-ARE
mediated
antioxidant
transcriptional
response.
reported
hijack
its
within
few
studies
suggested
role
antioxidants
modulating
Nrf2
manage
disease
severity.
This
review
highlights
interrelated
PI3K/Akt/Nrf2
pathways
that
can
help
ameliorate
severity
effective
antiviral
