Pesticide Biochemistry and Physiology, Год журнала: 2023, Номер 198, С. 105739 - 105739
Опубликована: Дек. 10, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Март 11, 2024
Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies
Язык: Английский
Процитировано
65
Current Obesity Reports, Год журнала: 2025, Номер 14(1)
Опубликована: Янв. 11, 2025
This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.
Язык: Английский
Процитировано
7
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(18), С. 10391 - 10405
Опубликована: Апрель 26, 2024
Metabolic-associated fatty liver disease (MAFLD) is witnessing a global surge; however, it still lacks effective pharmacological interventions. Fucoxanthin, natural bioactive metabolite derived from marine brown algae, exhibits promising functions, particularly in ameliorating metabolic disorders. However, the mechanisms underlying its therapeutic efficacy addressing MAFLD remain elusive. Our present findings indicated that fucoxanthin significantly alleviated palmitic acid (PA)-induced hepatic lipid deposition
Язык: Английский
Процитировано
15
Alimentary Pharmacology & Therapeutics, Год журнала: 2024, Номер 59(S1)
Опубликована: Май 30, 2024
Summary Background The current obesity pandemic has given rise to associated comorbidities and complications, including type 2 diabetes metabolic dysfunction‐associated steatotic liver disease (MASLD). During the last decade, certain glucagon‐like peptide 1 receptor agonists (GLP‐1RA), originally developed as antihyperglycemic drugs, also demonstrated efficacy for weight loss. Aims To review shared pathophysiologic features of common diseases compare therapeutic strategies reduce body related complications. Methods We performed an extensive literature research describe effects lifestyle modification, first‐generation anti‐obesity GLP‐1RA on loss in humans with obesity, MASLD. Results Until recently, treatment been limited which offer moderate degree sustainability few approved drugs are either short term use or forms obesity. Some significantly decrease caloric intake weight. Liraglutide semaglutide have therefore treating people They lead a reduction hepatic fat content inflammation biopsy‐confirmed Possible limitations comprise adverse effects, adherence persistence. Conclusion Certain superior modification inducing markedly changed portfolio additional beneficial disease.
Язык: Английский
Процитировано
12
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Янв. 25, 2024
Objective To compare the effects of four intermittent fasting regimens on blood glucose and insulin sensitivity in people with type 2 diabetes. Methods Randomized controlled trials treatment patients diabetes mellitus PubMed, Cochrane Library, Embase, ScienceDirect, Web Science, CNKI, VIP Database, WANFANG Database were searched for from library to September 2023. review authors independently screened studies extracted data. RevMan 5.4 was used direct comparison meta-results. Network meta-analysis performed using Stata16 software. Results 13 a total 867 included. The intervention twice-per-week fasting, fasting-mimicking diet, time-restricted eating, peridic better than that conventional diet. results network showed there no significant difference effect regimens. SUCRA ranking best comprehensive interventions improvement. Conclusion From perspective glucose, glycated hemoglobin resistance, has good effect, which can be as reference inter-type choose regimen. However, more clinical are needed verify this at later stage.
Язык: Английский
Процитировано
9
Science, Год журнала: 2024, Номер 386(6722), С. 673 - 677
Опубликована: Ноя. 7, 2024
Circadian desynchrony induced by shiftwork or jet lag is detrimental to metabolic health, but how synchronous desynchronous signals are transmitted among tissues unknown. We report that liver molecular clock dysfunction signaled the brain through hepatic vagal afferent nerve (HVAN), leading altered food intake patterns corrected ablation of HVAN. Hepatic branch vagotomy also prevents disruptions high-fat diet feeding and reduces body weight gain. Our findings reveal a homeostatic feedback signal relies on communication between control circadian patterns. This identifies vagus as potential therapeutic target for obesity in setting chronodisruption.
Язык: Английский
Процитировано
9
Acta Physiologica, Год журнала: 2023, Номер 239(2)
Опубликована: Авг. 8, 2023
The circadian timing system enables organisms to adapt their physiology and behavior the cyclic environmental changes including light-dark cycle or food availability. Misalignment between endogenous rhythms external cues is known as chronodisruption closely associated with development of metabolic gastrointestinal disorders, cardiovascular diseases, cancer. Time-restricted eating (TRE, in human) an emerging dietary approach for weight management. Recent studies have shown that TRE time-restricted feeding (TRF, when referring animals) has several beneficial health effects, which, however, are not limited This review summarizes effects TRE/TRF on regulating energy metabolism, gut microbiota homeostasis, diseases Furthermore, we will address role clocks propose ways optimize a strategy obtain maximal benefits.
Язык: Английский
Процитировано
14
PLoS ONE, Год журнала: 2024, Номер 19(1), С. e0296950 - e0296950
Опубликована: Янв. 29, 2024
Nonalcoholic steatohepatitis (NASH) occurs worldwide and is characterized by lipid accumulation in hepatocytes, hepatic inflammation, fibrosis, an increased risk of cirrhosis. Although a major proportion NASH patients exhibit obesity insulin resistance, 20% lack high body mass are categorized as “non-obese NASH”. Time-restricted feeding (TRF), limiting daily food intake within certain hours, improves obesity, metabolism, liver inflammation. Here, we determined whether TRF affects pathology induced choline-deficient high-fat diet (CDAHFD), which does not involve obesity. ameliorated the increase epididymal white adipose tissue plasma alanine transaminase aspartate levels after 8 weeks CDAHFD. gene expression TNF alpha was suppressed TRF, it did suppressive effect on accumulation, cytokines macrophage markers ( Mcp1 , IL1b F4/80 ), or evaluated Sirius red staining western blot analysis alpha-smooth muscle actin. A CDAHFD-induced related to fibrogenesis Collagen 1a1 TGFβ ) neither nor that actin but TRF. Our results indicated has limited pathology.
Язык: Английский
Процитировано
5
Nutrients, Год журнала: 2024, Номер 16(5), С. 722 - 722
Опубликована: Март 1, 2024
Background: The concept of time-restricted eating (TRE) or feeding (TRF) promotes daily periods and fasting to determine whole-body physiology. Chronic misalignment circadian rhythms chrono-disruption is related an increased risk diverse metabolic disorders. progression non-communicable diseases seems be affected by the timing meals. As a result, intermittent promising approach for their management. aim present literature review examine scrutinize TRE protocols in fields prevention management Methods: This thorough reported associations among rhythm, disorders, diabetes mellitus, obesity, TRE, TRF, dietary habits, disruption, cardiovascular diseases, atherosclerosis, non-alcoholic fatty liver find already existing clinical studies from last decade (2014–2024) most precise scientific online databases, using relevant specific keywords. Several inclusion exclusion criteria were applied only longitudinal, cross-sectional, descriptive, prospective human studies. Results: currently available findings remain scarce suggest that chrononutrition behaviors such as TRF may promote several benefits, mainly body weight control fat loss. Improvements glucose levels lipid profiles are quite controversial since some show little no effect. far concerned, efficacy stronger disease due decline Conclusions: Even if there has been gradual increase few years, providing perspectives, currently, conclusive evidence role Future should well-designed with longer duration larger sample sizes. Moreover, it important best window its feasibility.
Язык: Английский
Процитировано
5
Nutrients, Год журнала: 2023, Номер 15(17), С. 3724 - 3724
Опубликована: Авг. 25, 2023
Alternate-day fasting (ADF) is becoming more popular since it may be a promising diet intervention for human health. Our study aimed to conduct comprehensive bibliometric analysis investigate current publication trends and hotspots in the field of ADF. Publications regarding ADF were identified from Web Science Core Collection (WOSCC) database. VOSviewer 1.6.16 Online Analysis Platform used analyze hotspots. In total, there 184 publications 362 institutions 39 countries/regions, which published 104 journals. The most productive institutions, authors, journals USA, University Illinois Chicago, Krista A. Varady, Nutrients, respectively. first high-cited was PNAS authored by R. Michael Anson, also article about top five keywords with highest frequency as follows: calorie restriction, weight loss, intermittent fasting, obesity, body weight. conclusion, this related main research frontiers are obesity cardiometabolic risk, several different population groups including healthy adults patients diabetes, nonalcoholic fatty liver disease (NAFLD), cancer. number studies relatively small, needed extend our knowledge ADF, improve
Язык: Английский
Процитировано
11