Rho GTPase signaling in cancer progression and dissemination

Physiological Reviews, Год журнала: 2021, Номер 102(1), С. 455 - 510

Опубликована: Сен. 20, 2021

Rho GTPases are a family of small G proteins that regulate wide array cellular processes related to their key roles controlling the cytoskeleton. Cancer is multistep disease caused by accumulation genetic mutations and epigenetic alterations, from initial stages cancer development when cells in normal tissues undergo transformation, acquisition invasive metastatic traits, responsible for large number deaths. In this review, we discuss role GTPase signaling every step progression. contribute tumor initiation progression, regulating proliferation apoptosis, but also metabolism, senescence, cell stemness. play major migration process. They involved interactions with microenvironment inflammation, contributing After years intensive research, highlight importance relevant models field, reflect on therapeutic opportunities arising patients.

Язык: Английский

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Combined Photodynamic and Photothermal Therapy and Immunotherapy for Cancer Treatment: A Review

International Journal of Nanomedicine, Год журнала: 2022, Номер Volume 17, С. 6427 - 6446

Опубликована: Дек. 1, 2022

Photoactivation therapy based on photodynamic (PDT) and photothermal (PTT) has been identified as a tumour ablation modality for numerous cancer indications, with photosensitisers conversion agents playing important roles in the phototherapy process, especially recent decades.In addition, iteration of nanotechnology strongly promoted development treatment.PDT can increase sensitivity cells to PTT by interfering microenvironment, whereas heat generated blood flow, improve oxygen supply enhance PDT therapeutic effect.In cell debris serve tumour-associated antigens, evoking antitumor immune responses.In this review, research progress phototherapy, its effects combination immunotherapy treatment tumours are mainly outlined, issues that may need continued attention future raised.

Язык: Английский

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Biodegradable NIR‐II Pseudo Conjugate Polymeric Nanoparticles Amplify Photodynamic Immunotherapy via Alleviation of Tumor Hypoxia and Tumor‐Associated Macrophage Reprogramming

Advanced Materials, Год журнала: 2023, Номер 35(31)

Опубликована: Июнь 7, 2023

Photodynamic therapy (PDT) has achieved great success in cancer treatment. Despite its promise, the efficacy of photodynamic immunotherapy can be limited by hypoxia solid tumors which is closely related to abnormal tumor vasculature. These vasculatures are a hallmark most and facilitate immune evasion. Therefore, vascular normalization developed as promising strategy overcome hypoxia, resulting improved therapy. Here, NIR-II bio-degradable pseudo-conjugate polymer (PSP)-based designed deliver agent, i.e., regorafenib (Reg) nanoparticles (NP-PDT@Reg). NP-PDT@Reg under 808 nm laser irradiation (NP-PDT@Reg + L) efficiently release Reg improve via normalization, making more oxygen enter tumors. Moreover, L further result generation reactive species (ROS) eradicate cells while inducing immunogenic cell death (ICD) activate anti-tumor responses. In addition, reprogram TAM from pro-tumor M2 phenotype tumor-killing M1 well, thereby reversing immunosuppressive microenvironment. Taken together, current study provides an innovative perspective on development novel nanomaterials limitations immunotherapy.

Язык: Английский

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Preclinical to clinical utility of ROCK inhibitors in cancer

Trends in cancer, Год журнала: 2023, Номер 9(3), С. 250 - 263

Опубликована: Янв. 2, 2023

ROCK belongs to the AGC family of Ser/Thr protein kinases that are involved in many cellular processes. ROCK-driven actomyosin contractility regulates cytoskeletal dynamics underpinning cell migration, proliferation, and survival cancer types. ROCK1/2 play key protumorigenic roles several subtypes stages development. Therefore, successfully targeting its downstream effectors presents an interesting avenue for treatment. Because local use inhibitors will reduce side effects systemic administration, we propose different therapeutic strategies latest-generation clinic.

Язык: Английский

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Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(8), С. 3432 - 3456

Опубликована: Май 13, 2024

The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.

Язык: Английский

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The use of photodynamic therapy in medical practice

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Май 8, 2024

Cancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT’s efficacy, utilizing ROS generation induce cell death. With history spanning over decades, dynamic evolution has expanded its application across dermatology, oncology, dentistry. aims dissect principles, from inception contemporary medical applications, highlighting role in modern treatment strategies.

Язык: Английский

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How to improve photodynamic therapy-induced antitumor immunity for cancer treatment?

Theranostics, Год журнала: 2022, Номер 12(10), С. 4629 - 4655

Опубликована: Янв. 1, 2022

Photodynamic therapy (PDT) is a promising method of tumor ablation and function-preserving oncological intervention, which minimally invasive, repeatable, has excellent function cosmetic effect, with no cumulative toxicity.More importantly, PDT can induce immunogenic cell death local inflammation, thus stimulating the body's immune response.However, weak immunity induced by alone insufficient to trigger systemic response towards cancer cells.To overcome this obstacle, multiple strategies have been investigated, including microenvironment remodeling, vaccines, subcellular-targeted PDT, synergistic therapies.This review summarizes latest progress in development improve PDT-induced effect for enhanced treatment.

Язык: Английский

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Rho-Kinase as a Target for Cancer Therapy and Its Immunotherapeutic Potential

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(23), С. 12916 - 12916

Опубликована: Ноя. 29, 2021

Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment, harnessing the immune system to fight against numerous types cancer. Rho-kinase (ROCK) pathway involved in diverse cellular activities, and therefore target interest various diseases at level including Indeed, ROCK well-known for its involvement tumor cell microenvironment, especially ability enhance progression, migration, metastasis, extracellular matrix remodeling. Importantly, also considered be novel effective modulator cells, although further studies are needed. In this review article, we describe activities potential utilized particularly immunotherapy, by shining light on system.

Язык: Английский

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Oxidative Stress Amplifiers as Immunogenic Cell Death Nanoinducers Disrupting Mitochondrial Redox Homeostasis for Cancer Immunotherapy

Advanced Healthcare Materials, Год журнала: 2022, Номер 12(9)

Опубликована: Дек. 17, 2022

Abstract Reactive oxygen species (ROS)‐induced oxidative stress in the endoplasmic reticulum (ER) is generally believed to be an important prerequisite for immunogenic cell death (ICD) which can trigger antitumor immune responses cancer immunotherapy. However, thus far, little known between a certain organelle other than ER and ICD. Herein, polymers preparing ROS‐responsive nanoparticles (NP‐I‐CA‐TPP) with mitochondrial targeting performance as ICD nanoinducers are designed. It that NP‐I‐CA‐TPP target mitochondria extremely organelles intimately involved cellular signaling play role induction of amplify cinnamaldehyde (CA)‐induced ROS damage by iodo–thiol click chemistry‐mediated glutathione depletion cells. Finally, shown disrupt redox homeostasis, stress, promote apoptosis via inducing ICD, triggering body's response

Язык: Английский

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Recent advances in light-triggered cancer immunotherapy

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(11), С. 2650 - 2669

Опубликована: Янв. 1, 2024

Combining phototherapies, particularly PDT and PTT, with immunotherapy synergistically stimulates immune responses, offering promising strategies for effective cancer treatment prevention of recurrence.

Язык: Английский

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