Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method

Magnetic Resonance in Medical Sciences, Год журнала: 2024, Номер 23(3), С. 268 - 290

Опубликована: Янв. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Язык: Английский

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The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants

Alzheimer s Research & Therapy, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 20, 2024

Abstract Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel (CSVD) the most common pathogenesis We hypothesize that AD and CSVD could be associated glymphatic dysfunction, contributing to cognitive impairment. Method Participants completed amyloid PET, diffusion tensor imaging (DTI), T2 fluid-attenuated inversion-recovery (FLAIR) sequences were included from Disease Neuroimaging Initiative (ADNI). White matter hyperintensities (WMH), marker, was evaluated T2FLAIR images represented burden of CSVD. Amyloid PET used assess Aβ aggregation in brain. image analysis along perivascular space (DTI-ALPS) index, enlarged spaces (PVS), choroid plexus volume reflect function. The relationships between WMH burden/Aβ these markers as well correlations function investigated. Furthermore, we conducted mediation analyses explore potential mediating effects relationship cognition. Results One hundred thirty-three participants continuum included, consisting 40 CN − , 48 + 26 MCI 19 participants. Our findings revealed there negative associations whole-brain ( r = 0.249, p 0.022) 0.458, < 0.001) DTI-ALPS. Additionally, 0.223, 0.041) 0.294, 0.006) both positively volume. However, did not observe significant PVS enlargement severity. DTI-ALPS memory 0.470, FDR- 0.001), executive 0.358, visual-spatial 0.040), language 0.419, 0.001). Conversely, showed 0.315, 0.007), 0.321, 0.233, 0.031), 0.261, 0.021). There no severity performance. In analysis, found acted mediator accumulation performances. Conclusion study provided evidence pathology (Aβ) which further related These results may provide theoretical basis new targets treating AD.

Язык: Английский

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Perivascular Spaces, Diffusivity Along Perivascular Spaces, and Free Water in Cerebral Small Vessel Disease

Neurology, Год журнала: 2024, Номер 102(9)

Опубликована: Апрель 16, 2024

Previous studies have linked the MRI measures of perivascular spaces (PVSs), diffusivity along (DTI-ALPS), and free water (FW) to cerebral small vessel disease (SVD) SVD-related cognitive impairments. However, on longitudinal associations between three measures, SVD progression, decline are lacking. This study aimed explore how PVS, DTI-ALPS, FW contribute progression decline.

Язык: Английский

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The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle

Neurobiology of Disease, Год журнала: 2024, Номер 192, С. 106426 - 106426

Опубликована: Фев. 6, 2024

The term "glymphatic" emerged roughly a decade ago, marking pivotal point in neuroscience research. glymphatic system, glial-dependent perivascular network distributed throughout the brain, has since become focal of investigation. There is increasing evidence suggesting that impairment system appears to be common feature neurodegenerative disorders, and this exacerbates as disease progression. Nevertheless, factors contributing dysfunction across most disorders remain unclear. Inflammation, however, suspected play role. Dysfunction can lead significant accumulation protein waste products, which trigger inflammation. interaction between inflammation cyclical potentially synergistic. Yet, current research limited, there lack comprehensive models explaining association. In perspective review, we propose novel model inflammation, impaired function, interconnected vicious cycle. By presenting experimental from existing literature, aim demonstrate that: (1) aggravates dysfunction, (2) exacerbated progression, (3) progression promotes Finally, implication proposed discussed.

Язык: Английский

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Pathophysiology of cerebral small vessel disease: a journey through recent discoveries

Journal of Clinical Investigation, Год журнала: 2024, Номер 134(10)

Опубликована: Май 14, 2024

Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related pathologies that affect multiple regions. Disease manifestations range from lesions incidentally detected on neuroimaging (white matter hyperintensities, deep infarcts, microbleeds, or enlarged perivascular spaces) to severe disability and cognitive impairment. cSVD accounts for approximately 25% ischemic strokes the vast majority spontaneous intracerebral hemorrhage is also most important vascular contributor dementia. Despite its high prevalence potentially long therapeutic window, there are still no mechanism-based treatments. Here, we provide an overview recent advances in this field. We summarize data highlighting remarkable continuum between monogenic multifactorial cSVDs involving NOTCH3, HTRA1, COL4A1/A2 genes. Taking vessel-centric view, discuss possible cause-and-effect relationships risk factors, structural functional changes, manifestations, underscoring some major knowledge gaps. Although endothelial dysfunction rightly considered central feature cSVD, contributions smooth muscle cells, pericytes, other cells warrant continued investigation.

Язык: Английский

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Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease

Journal of Neuroradiology, Год журнала: 2025, Номер 52(3), С. 101322 - 101322

Опубликована: Янв. 31, 2025

Язык: Английский

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Relationship of Perivascular Space Markers With Incident Dementia in Cerebral Small Vessel Disease

Stroke, Год журнала: 2024, Номер 55(4), С. 1032 - 1040

Опубликована: Март 11, 2024

BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between PVS, measured DTI-ALPS and PVS volume, cognition incident dementia. METHODS: In patients with lacunar stroke confluent white matter hyperintensities, without dementia at baseline, recruited prospectively a single center, magnetic resonance imaging was performed annually for 3 years, cognitive assessments, including global, memory, executive function, processing speed, 5 years. volume disease markers (white hyperintensity lacunes, microbleeds) baseline changes markers. whether change over years predicted Analyses controlled conventional metrics 2 (median mean diffusivity [MD] peak width of skeletonized MD) adjusted age, sex, vascular risk factors. RESULTS: A total 120 patients, age 70.0 65.0% male, included. declined while no found. Neither nor associated marker progression. Baseline global (β=0.142, P =0.032), (β=0.287, =0.027), long-term memory (β=0.228, =0.027). Higher lower (hazard ratio, 0.328 [0.183–0.588]; <0.001), this remained significant after median MD as covariate 0.290 [0.139–0.602]; <0.001). Change conversion 0.630 [0.428–0.964]; =0.048), when entered covariates, association not significant. There or to CONCLUSIONS: predicts future strokes hyperintensities. However, weakening controlling suggests part signal may represent metrics. is predictor risk.

Язык: Английский

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Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements

NMR in Biomedicine, Год журнала: 2024, Номер 37(9)

Опубликована: Май 7, 2024

Abstract Cerebrospinal fluid (CSF) plays a critical role in metabolic waste clearance from the brain, requiring its circulation throughout various brain pathways, including ventricular system, subarachnoid spaces, para‐arterial interstitial and para‐venous spaces. The complexity of CSF has posed challenge obtaining noninvasive measurements dynamics. assessment dynamics circulatory pathways is possible using diffusion magnetic resonance imaging (MRI) with optimized sensitivity to incoherent water movement across brain. This review presents an overview both established emerging MRI techniques designed measure their potential clinical applications. discussion offers insights into optimization acquisition parameters enhance specificity metrics on underlying Lastly, we emphasize importance cautious interpretations diffusion‐based imaging, especially when differentiating between tissue‐ fluid‐related changes or elucidating structural versus functional alterations.

Язык: Английский

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Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Understanding how sleep affects the glymphatic system and human brain networks is crucial for elucidating neurophysiological mechanism underpinning aging-related memory declines. We analyzed a multimodal dataset collected through magnetic resonance imaging (MRI) polysomnographic recording from 72 older adults. A proxy of functioning was obtained Diffusion Tensor Image Analysis along Perivascular Space (DTI-ALPS) index. Structural functional were constructed based on MRI data, coupling between two (SC-FC coupling) also calculated. Correlation analyses revealed that DTI-ALPS negatively correlated with quality measures [e.g., Pittsburgh Sleep Quality Index (PSQI) apnea-hypopnea index]. Regarding networks, associated strength both connectivity (FC) structural (SC) involving regions such as middle temporal gyrus parahippocampal gyrus, well SC-FC rich-club connections. Furthermore, we found positively mediated association coupling. The further function in good sleepers but not poor sleepers. results suggest disrupted glymphatic-brain relationship sleepers, which underlies decline. Our findings add important evidence cognitive health underlying neural relationships interplay networks.

Язык: Английский

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Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease

Movement Disorders, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract Background The aim was to investigate if glymphatic function is impaired in patients with Huntington's disease (HD) and its clinical relevance. Methods Forty‐nine subjects carrying mutant Huntingtin (m HTT ), comprising 35 manifest (mHD) 14 pre‐manifest (PreHD), healthy controls (HC) were recruited this study. diffusion along perivascular spaces (ALPS) index the percentage of space basal ganglia (pPVS_BG) obtained different groups. discrimination effects ALPS detected using receiver operating characteristic (ROC) analysis, correlations features HD further analyzed. Results decreased m carriers compared HCs, it lower mHD PreHD patients. ROC analysis showed that could discriminate from HC (AUC [area under curve] = 0.903), 0.886), 0.755). Lower correlated greater burden, severity disease, lager pPVS_BG, brain volume thickness cortices. Regression predict performance motor cognitive functions. Mediation revealed partially mediated CAG repeat age on decline HD. Conclusions This study demonstrated impairment system, especially paraventricular white matter BG, manifestations, structural changes carriers. © 2025 Author(s). Movement Disorders published by Wiley Periodicals LLC behalf International Parkinson Disorder Society.

Язык: Английский

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