International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(5), С. 2715 - 2715
Опубликована: Март 8, 2021
Cardiovascular
disease
is
the
leading
cause
of
mortality
and
morbidity
around
globe,
creating
a
substantial
socio-economic
burden
as
result.
Myocardial
infarction
significant
contributor
to
detrimental
impact
cardiovascular
disease.
The
death
cardiomyocytes
following
myocardial
causes
an
immune
response
which
leads
further
destruction
tissue,
subsequently,
results
in
formation
non-contractile
scar
tissue.
Macrophages
have
been
recognized
important
regulators
participants
inflammation
fibrosis
infarction.
are
generally
classified
into
two
distinct
groups,
namely,
classically
activated,
or
M1
macrophages,
alternatively
M2
macrophages.
phenotypic
profile
cardiac
however,
much
more
diverse
should
not
be
reduced
these
subsets.
In
this
review,
we
describe
phenotypes
functions
macrophages
present
healthy,
well
infarcted
heart,
analyze
them
with
respect
polarization
states.
Furthermore,
discuss
therapeutic
strategies
utilize
macrophage
towards
anti-inflammatory
reparative
phenotype
for
treatment
Annual Review of Pathology Mechanisms of Disease,
Год журнала:
2021,
Номер
16(1), С. 93 - 122
Опубликована: Янв. 24, 2021
Immunotherapy
has
revolutionized
cancer
treatment
over
the
past
decade.
Nonetheless,
prolonged
survival
is
limited
to
relatively
few
patients.
Cancers
enforce
a
multifaceted
immune-suppressive
network
whose
nature
progressively
shaped
by
systemic
and
local
cues
during
tumor
development.
Monocytes
bridge
innate
adaptive
immune
responses
can
affect
microenvironment
through
various
mechanisms
that
induce
tolerance,
angiogenesis,
increased
dissemination
of
cells.
Yet
monocytes
also
give
rise
antitumor
effectors
activate
antigen-presenting
This
yin-yang
activity
relies
on
plasticity
in
response
environmental
stimuli.
In
this
review,
we
summarize
current
knowledge
ontogeny,
heterogeneity,
functions
monocyte-derived
cells
cancer,
pinpointing
main
pathways
are
important
for
modeling
immunosuppressive
microenvironment.
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Дек. 7, 2021
Periodontitis
(PD)
is
a
common
chronic
infectious
disease.
The
local
inflammatory
response
in
the
host
may
cause
destruction
of
supporting
periodontal
tissue.
Macrophages
play
variety
roles
PD,
including
regulatory
and
phagocytosis.
Moreover,
under
induction
different
factors,
macrophages
polarize
form
functional
phenotypes.
Among
them,
M1-type
with
proinflammatory
functions
M2-type
anti-inflammatory
are
most
representative,
both
them
can
regulate
tendency
immune
system
to
exert
or
functions.
M1
M2
involved
destructive
reparative
stages
PD.
Due
complex
microenvironment
dynamic
development
various
mediators,
increasing
attention
has
been
given
study
macrophage
polarization
This
review
summarizes
role
PD
its
research
progress.
npj Precision Oncology,
Год журнала:
2024,
Номер
8(1)
Опубликована: Фев. 10, 2024
Abstract
Tumor
drug
resistance
emerges
from
the
interaction
of
two
critical
factors:
tumor
cellular
heterogeneity
and
immunosuppressive
nature
microenvironment
(TME).
Tumor-associated
macrophages
(TAMs)
constitute
essential
components
TME.
M2-like
TAMs
are
in
facilitating
metastasis
as
well
augmenting
tumors.
This
review
encapsulates
mechanisms
that
use
to
promote
resistance.
We
also
describe
emerging
therapeutic
strategies
currently
targeting
combination
with
other
antitumor
drugs,
some
still
undergoing
clinical
trial
evaluation.
Furthermore,
we
summarize
analyze
various
existing
approaches
for
developing
novel
drugs
target
overcome
resistance,
highlighting
how
can
effectively
stop
growth,
metastasis,
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Июнь 5, 2023
Abstract
Amino
acids
are
basic
nutrients
for
immune
cells
during
organ
development,
tissue
homeostasis,
and
the
response.
Regarding
metabolic
reprogramming
in
tumor
microenvironment,
dysregulation
of
amino
acid
consumption
is
an
important
underlying
mechanism
leading
to
impaired
anti-tumor
immunity.
Emerging
studies
have
revealed
that
altered
metabolism
tightly
linked
outgrowth,
metastasis,
therapeutic
resistance
through
governing
fate
various
cells.
During
these
processes,
concentration
free
acids,
their
membrane
bound
transporters,
key
enzymes,
sensors
such
as
mTOR
GCN2
play
critical
roles
controlling
cell
differentiation
function.
As
such,
anti-cancer
responses
could
be
enhanced
by
supplement
specific
essential
or
targeting
enzymes
sensors,
thereby
developing
novel
adjuvant
modalities.
To
further
dissect
regulation
immunity,
this
review
summarizes
regulatory
mechanisms
effects
on
phenotypes
functions
tumor-infiltrating
propose
approaches
exploited
rewire
enhance
cancer
immunotherapy.
New England Journal of Medicine,
Год журнала:
2020,
Номер
383(11), С. 1078 - 1080
Опубликована: Сен. 9, 2020
Training
Innate
Immunity
A
recent
study
of
immunity
in
mice
showed
that
the
innate
immune
system
can
be
primed
to
respond
later
bacterial
infection
through
a
process
called
epigenetic
scarring,
...
Cells,
Год журнала:
2021,
Номер
10(11), С. 3194 - 3194
Опубликована: Ноя. 16, 2021
Nitric
oxide
and
its
production
by
iNOS
is
an
established
mechanism
critical
to
tumor
promotion
or
suppression.
Macrophages
have
important
roles
in
immunity,
development,
progression
of
cancer
a
controversial
role
pro-
antitumoral
effects.
The
microenvironment
consists
tumor-associated
macrophages
(TAM),
among
other
cell
types
that
influence
the
fate
growing
tumor.
Depending
on
various
cues,
polarize
into
continuum
represented
M1-like
pro-inflammatory
phenotype
anti-inflammatory
M2-like
phenotype;
these
two
are
predominant,
while
there
subsets
intermediates.
Manipulating
their
plasticity
through
programming
reprogramming
phenotypes
presents
opportunity
maximize
tumoricidal
defenses.
dual
iNOS-derived
NO
also
influences
TAM
activity
repolarization
M1-type
phenotype.
Regulatory
pathways
immunomodulation
achieve
this
miRNA
may
inhibit
immunosuppressive
microenvironment.
This
review
summarizes
classical
physiology
polarization,
activities,
evidence
towards
with
current
information
glioblastoma
melanoma
models,
immunomodulatory
therapeutic
options
using
NO-dependent
strategies.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114985 - 114985
Опубликована: Июнь 11, 2023
The
gut
microbiota
is
indispensable
for
maintaining
host
health
by
enhancing
the
host's
digestive
capacity,
safeguarding
intestinal
epithelial
barrier,
and
preventing
pathogen
invasion.
Additionally,
exhibits
a
bidirectional
interaction
with
immune
system
promotes
of
to
mature.
Dysbiosis
microbiota,
primarily
caused
factors
such
as
genetic
susceptibility,
age,
BMI,
diet,
drug
abuse,
significant
contributor
inflammatory
diseases.
However,
mechanisms
underlying
diseases
resulting
from
dysbiosis
lack
systematic
categorization.
In
this
study,
we
summarize
normal
physiological
functions
symbiotic
in
healthy
state
demonstrate
that
when
occurs
due
various
external
factors,
are
lost,
leading
pathological
damage
lining,
metabolic
disorders,
barrier
damage.
This,
turn,
triggers
disorders
eventually
causes
systems.
These
discoveries
provide
fresh
perspectives
on
how
diagnose
treat
unrecognized
variables
might
affect
link
between
illnesses
need
further
studies
extensive
basic
clinical
research
will
still
be
required
investigate
relationship
future.