Monocytes in the Tumor Microenvironment

Annual Review of Pathology Mechanisms of Disease, Год журнала: 2021, Номер 16(1), С. 93 - 122

Опубликована: Янв. 24, 2021

Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature progressively shaped by systemic and local cues during tumor development. Monocytes bridge innate adaptive immune responses can affect microenvironment through various mechanisms that induce tolerance, angiogenesis, increased dissemination of cells. Yet monocytes also give rise antitumor effectors activate antigen-presenting This yin-yang activity relies on plasticity in response environmental stimuli. In this review, we summarize current knowledge ontogeny, heterogeneity, functions monocyte-derived cells cancer, pinpointing main pathways are important for modeling immunosuppressive microenvironment.

Язык: Английский

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The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

Cancer Cell, Год журнала: 2021, Номер 39(7), С. 945 - 957.e10

Опубликована: Май 20, 2021

Язык: Английский

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Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Дек. 7, 2021

Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response in the host may cause destruction of supporting periodontal tissue. Macrophages play variety roles PD, including regulatory and phagocytosis. Moreover, under induction different factors, macrophages polarize form functional phenotypes. Among them, M1-type with proinflammatory functions M2-type anti-inflammatory are most representative, both them can regulate tendency immune system to exert or functions. M1 M2 involved destructive reparative stages PD. Due complex microenvironment dynamic development various mediators, increasing attention has been given study macrophage polarization This review summarizes role PD its research progress.

Язык: Английский

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Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance

npj Precision Oncology, Год журнала: 2024, Номер 8(1)

Опубликована: Фев. 10, 2024

Abstract Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and immunosuppressive nature microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components TME. M2-like TAMs are in facilitating metastasis as well augmenting tumors. This review encapsulates mechanisms that use to promote resistance. We also describe emerging therapeutic strategies currently targeting combination with other antitumor drugs, some still undergoing clinical trial evaluation. Furthermore, we summarize analyze various existing approaches for developing novel drugs target overcome resistance, highlighting how can effectively stop growth, metastasis,

Язык: Английский

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CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours

Nature, Год журнала: 2023, Номер 618(7967), С. 1033 - 1040

Опубликована: Июнь 14, 2023

Most clinically applied cancer immunotherapies rely on the ability of CD8

Язык: Английский

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Tumor-associated myeloid cells: diversity and therapeutic targeting

Cellular and Molecular Immunology, Год журнала: 2021, Номер 18(3), С. 566 - 578

Опубликована: Янв. 20, 2021

Язык: Английский

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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)

Опубликована: Июнь 5, 2023

Abstract Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the response. Regarding metabolic reprogramming in tumor microenvironment, dysregulation of amino acid consumption is an important underlying mechanism leading to impaired anti-tumor immunity. Emerging studies have revealed that altered metabolism tightly linked outgrowth, metastasis, therapeutic resistance through governing fate various cells. During these processes, concentration free acids, their membrane bound transporters, key enzymes, sensors such as mTOR GCN2 play critical roles controlling cell differentiation function. As such, anti-cancer responses could be enhanced by supplement specific essential or targeting enzymes sensors, thereby developing novel adjuvant modalities. To further dissect regulation immunity, this review summarizes regulatory mechanisms effects on phenotypes functions tumor-infiltrating propose approaches exploited rewire enhance cancer immunotherapy.

Язык: Английский

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Trained Innate Immunity, Epigenetics, and Covid-19

New England Journal of Medicine, Год журнала: 2020, Номер 383(11), С. 1078 - 1080

Опубликована: Сен. 9, 2020

Training Innate Immunity A recent study of immunity in mice showed that the innate immune system can be primed to respond later bacterial infection through a process called epigenetic scarring, ...

Язык: Английский

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Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO

Cells, Год журнала: 2021, Номер 10(11), С. 3194 - 3194

Опубликована: Ноя. 16, 2021

Nitric oxide and its production by iNOS is an established mechanism critical to tumor promotion or suppression. Macrophages have important roles in immunity, development, progression of cancer a controversial role pro- antitumoral effects. The microenvironment consists tumor-associated macrophages (TAM), among other cell types that influence the fate growing tumor. Depending on various cues, polarize into continuum represented M1-like pro-inflammatory phenotype anti-inflammatory M2-like phenotype; these two are predominant, while there subsets intermediates. Manipulating their plasticity through programming reprogramming phenotypes presents opportunity maximize tumoricidal defenses. dual iNOS-derived NO also influences TAM activity repolarization M1-type phenotype. Regulatory pathways immunomodulation achieve this miRNA may inhibit immunosuppressive microenvironment. This review summarizes classical physiology polarization, activities, evidence towards with current information glioblastoma melanoma models, immunomodulatory therapeutic options using NO-dependent strategies.

Язык: Английский

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Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114985 - 114985

Опубликована: Июнь 11, 2023

The gut microbiota is indispensable for maintaining host health by enhancing the host's digestive capacity, safeguarding intestinal epithelial barrier, and preventing pathogen invasion. Additionally, exhibits a bidirectional interaction with immune system promotes of to mature. Dysbiosis microbiota, primarily caused factors such as genetic susceptibility, age, BMI, diet, drug abuse, significant contributor inflammatory diseases. However, mechanisms underlying diseases resulting from dysbiosis lack systematic categorization. In this study, we summarize normal physiological functions symbiotic in healthy state demonstrate that when occurs due various external factors, are lost, leading pathological damage lining, metabolic disorders, barrier damage. This, turn, triggers disorders eventually causes systems. These discoveries provide fresh perspectives on how diagnose treat unrecognized variables might affect link between illnesses need further studies extensive basic clinical research will still be required investigate relationship future.

Язык: Английский

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