The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

Cancer Cell, Journal Year: 2021, Volume and Issue: 39(7), P. 945 - 957.e10

Published: May 20, 2021

Language: Английский

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M1/M2 macrophages and their overlaps – myth or reality?

Clinical Science, Journal Year: 2023, Volume and Issue: 137(15), P. 1067 - 1093

Published: Aug. 1, 2023

Abstract Macrophages represent heterogeneous cell population with important roles in defence mechanisms and homoeostasis. Tissue macrophages from diverse anatomical locations adopt distinct activation states. M1 M2 are two polarized forms of mononuclear phagocyte vitro differentiation phenotypic patterns functional properties, but vivo, there is a wide range different macrophage phenotypes between depending on the microenvironment natural signals they receive. In human infections, pathogens use strategies to combat these include shaping polarization towards one or another phenotype. infiltrating tumours can affect patient’s prognosis. have been shown promote tumour growth, while provide both tumour-promoting anti-tumour properties. autoimmune diseases, prolonged activation, as well altered function contribute their onset activity. atherosclerotic lesions, expressing profiles detected potential factors affecting occurrence cardiovascular diseases. allergic inflammation, T2 cytokines drive profiles, which airway inflammation remodelling. transplantations seem acute rejection, fibrosis graft. The view pro-inflammatory suppressing seems be an oversimplification because cells exploit very high level plasticity large scale immunophenotypes overlapping this respect, it would more precise describe M1-like M2-like.

Language: Английский

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Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 7, 2021

Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response in the host may cause destruction of supporting periodontal tissue. Macrophages play variety roles PD, including regulatory and phagocytosis. Moreover, under induction different factors, macrophages polarize form functional phenotypes. Among them, M1-type with proinflammatory functions M2-type anti-inflammatory are most representative, both them can regulate tendency immune system to exert or functions. M1 M2 involved destructive reparative stages PD. Due complex microenvironment dynamic development various mediators, increasing attention has been given study macrophage polarization This review summarizes role PD its research progress.

Language: Английский

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CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours

Nature, Journal Year: 2023, Volume and Issue: 618(7967), P. 1033 - 1040

Published: June 14, 2023

Most clinically applied cancer immunotherapies rely on the ability of CD8

Language: Английский

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Trained Innate Immunity, Epigenetics, and Covid-19

New England Journal of Medicine, Journal Year: 2020, Volume and Issue: 383(11), P. 1078 - 1080

Published: Sept. 9, 2020

Training Innate Immunity A recent study of immunity in mice showed that the innate immune system can be primed to respond later bacterial infection through a process called epigenetic scarring, ...

Language: Английский

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Tumor-associated myeloid cells: diversity and therapeutic targeting

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 18(3), P. 566 - 578

Published: Jan. 20, 2021

Language: Английский

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Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 10, 2024

Abstract Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and immunosuppressive nature microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components TME. M2-like TAMs are in facilitating metastasis as well augmenting tumors. This review encapsulates mechanisms that use to promote resistance. We also describe emerging therapeutic strategies currently targeting combination with other antitumor drugs, some still undergoing clinical trial evaluation. Furthermore, we summarize analyze various existing approaches for developing novel drugs target overcome resistance, highlighting how can effectively stop growth, metastasis,

Language: Английский

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Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO

Cells, Journal Year: 2021, Volume and Issue: 10(11), P. 3194 - 3194

Published: Nov. 16, 2021

Nitric oxide and its production by iNOS is an established mechanism critical to tumor promotion or suppression. Macrophages have important roles in immunity, development, progression of cancer a controversial role pro- antitumoral effects. The microenvironment consists tumor-associated macrophages (TAM), among other cell types that influence the fate growing tumor. Depending on various cues, polarize into continuum represented M1-like pro-inflammatory phenotype anti-inflammatory M2-like phenotype; these two are predominant, while there subsets intermediates. Manipulating their plasticity through programming reprogramming phenotypes presents opportunity maximize tumoricidal defenses. dual iNOS-derived NO also influences TAM activity repolarization M1-type phenotype. Regulatory pathways immunomodulation achieve this miRNA may inhibit immunosuppressive microenvironment. This review summarizes classical physiology polarization, activities, evidence towards with current information glioblastoma melanoma models, immunomodulatory therapeutic options using NO-dependent strategies.

Language: Английский

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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: June 5, 2023

Abstract Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the response. Regarding metabolic reprogramming in tumor microenvironment, dysregulation of amino acid consumption is an important underlying mechanism leading to impaired anti-tumor immunity. Emerging studies have revealed that altered metabolism tightly linked outgrowth, metastasis, therapeutic resistance through governing fate various cells. During these processes, concentration free acids, their membrane bound transporters, key enzymes, sensors such as mTOR GCN2 play critical roles controlling cell differentiation function. As such, anti-cancer responses could be enhanced by supplement specific essential or targeting enzymes sensors, thereby developing novel adjuvant modalities. To further dissect regulation immunity, this review summarizes regulatory mechanisms effects on phenotypes functions tumor-infiltrating propose approaches exploited rewire enhance cancer immunotherapy.

Language: Английский

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CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: July 14, 2021

Cancer associated fibroblasts (CAFs) and tumor macrophages (TAMs) are among the most important abundant players of microenvironment. CAFs as well TAMs known to play pivotal supportive roles in growth progression. The number CAF or TAM cells is mostly correlated with poor prognosis. Both a reciprocal communication milieu . In addition such interactions, also involved dynamic interrelationship each other. capable altering other’s functions. Here, current understanding distinct mechanisms about complex interplay between summarized. addition, consequences mutual relationship especially for progression immune evasion highlighted, focusing on synergistic pleiotropic effects. crucial components microenvironment; thus, they may prove be potential therapeutic targets. A better tri-directional interactions CAFs, cancer terms will pave way identification novel theranostic cues order target carcinogenesis.

Language: Английский

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