The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июнь 10, 2022

Periodontitis is an infectious oral disease, which leads to the destruction of periodontal tissues and tooth loss. Although treatment periodontitis has improved recently, effective periodontitis-affected still a challenge. Therefore, it urgent explore new therapeutic strategies for periodontitis. Natural products show anti-microbial, anti-inflammatory, anti-oxidant bone protective effects most these natural are safe cost-effective. Among these, plant-derived exosome-like nanoparticles (PELNs), type nanocarriers repleted with lipids, proteins, RNAs, other active molecules, ability enter mammalian cells regulate cellular activities. Reports from literature indicate great potential PELNs in regulation immune functions, inflammation, microbiome, tissue regeneration. Moreover, can also be used as drug carriers enhance stability uptake vivo. Since function, regeneration key phenomena usually targeted during treatment, hold promising treatment. This review summarizes recent advances PELNs-related research that related periodontitis-destructed underlying mechanisms. We discuss existing challenges prospects application PELNs-based approaches

Язык: Английский

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Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Март 6, 2024

Abstract Background Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in pathogenesis alveolar bone defect caused by periodontitis. Unfortunately, there is still a lack ideal therapeutic strategies for periodontitis that can regenerate while remodeling microenvironment. Quercetin, as monomeric flavonoid, has multiple pharmacological activities, such pro-regenerative, anti-inflammatory, immunomodulatory effects. Despite its vast spectrum quercetin’s clinical application limited due to poor water solubility low bioavailability. Results In this study, we fabricated quercetin-loaded mesoporous bioactive glass (Quercetin/MBG) nano-delivery system with function continuously releasing quercetin, which could better promote regeneration regulate immune microenvironment compared pure MBG treatment. particular, effectively decreased injection frequency quercetin yielding favorable results. view above excellent effects achieved sustained release further investigated mechanisms. Our findings indicated under microenvironment, intervention restore osteo-/angiogenic capacity periodontal ligament stem cells (PDLSCs), induce regulation macrophages exert an osteoimmunomodulatory effect. Furthermore, also found via be partially blocked overexpression key microRNA——miR-21a-5p, worked through inhibiting expression PDCD4 activating NF-κB signaling pathway. Conclusion summary, our study shows potential approach reconstructing defects it offers new perspective treating miR-21a-5p thereby creating Graphical

Язык: Английский

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New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 4, 2024

Abstract Periodontitis is a chronic inflammatory disease caused by the local microbiome and host immune response, resulting in periodontal structure damage even tooth loss. Scaling root planning combined with antibiotics are conventional means of nonsurgical treatment periodontitis, but they insufficient to fully heal periodontitis due intractable bacterial attachment drug resistance. Novel effective therapeutic options clinical therapy remain scarce. Nanotherapeutics achieve stable cell targeting, oral retention smart release great flexibility changing chemical composition or physical characteristics nanoparticles. Meanwhile, protectiveness high surface area volume ratio nanoparticles enable loading, ensuring remarkable efficacy. Currently, combination advanced novel strategies most active research treatment. In this review, we first introduce pathogenesis then summarize state-of-the-art nanotherapeutic based on triple concerto antibacterial activity, immunomodulation periodontium regeneration, particularly focusing mechanism ingenious design nanomedicines. Finally, challenges prospects nano for discussed from perspective current problems future development trends. Graphical

Язык: Английский

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The role of microRNAs in the gastric cancer tumor microenvironment

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 20, 2024

Gastric cancer (GC) is one of the deadliest malignant tumors with unknown pathogenesis. Due to its treatment resistance, high recurrence rate, and lack reliable early detection techniques, a majority patients have poor prognosis. Therefore, identifying new tumor biomarkers therapeutic targets essential. This review aims provide fresh insights into enhancing prognosis GC by summarizing processes through which microRNAs (miRNAs) regulate microenvironment (TME) highlighting their critical role in TME. A comprehensive literature was conducted focusing on interactions among cells, extracellular matrix, blood vessels, cancer-associated fibroblasts, immune cells within The noncoding RNAs, known as miRNAs, modulating TME various signaling pathways, cytokines, growth factors, exosomes specifically examined. Tumor formation, metastasis, therapy are significantly influenced miRNAs progression these multiple exosomes. Dysregulation affects cellular such cell proliferation, differentiation, angiogenesis, contributing pathogenesis GC. play crucial regulation TME, influencing patient By understanding mechanisms control potential can be identified improve

Язык: Английский

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Topography-mediated immunomodulation in osseointegration; Ally or Enemy

Biomaterials, Год журнала: 2022, Номер 291, С. 121903 - 121903

Опубликована: Ноя. 9, 2022

Язык: Английский

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Inhibition of ROCK ameliorates pulmonary fibrosis by suppressing M2 macrophage polarisation through phosphorylation of STAT3

Clinical and Translational Medicine, Год журнала: 2022, Номер 12(10)

Опубликована: Сен. 30, 2022

Язык: Английский

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Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration

npj Regenerative Medicine, Год журнала: 2022, Номер 7(1)

Опубликована: Дек. 22, 2022

Abstract Reconstruction of complex cartilage defects has remained a great challenge for tissue engineering due to the lack stem cells and chronic inflammation within joint. In this study, we have developed an injectable pig cartilage-derived decellularized extracellular matrix (dECM) hydrogels repair defects, which shown sound biocompatibility immunomodulatory capacity both in vitro vivo. The dECM can enhance chondrogenic differentiation human urine-derived (USCs). As by experiment, USCs survived, proliferated, produced mass cartilage-specific containing collagen II aggrecan. And USCs-laden promote secretion matrix, modulate immune response regeneration rat model defect.

Язык: Английский

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Osteoimmunology in Periodontitis and Orthodontic Tooth Movement

Current Osteoporosis Reports, Год журнала: 2023, Номер 21(2), С. 128 - 146

Опубликована: Март 2, 2023

Язык: Английский

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Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114688 - 114688

Опубликована: Апрель 15, 2023

Periodontitis is a chronic inflammatory disease initiated by pathogenic biofilms and host immunity that damages tooth-supporting tissues, including the gingiva, periodontal ligament alveolar bone. The physiological functions of oral cavity, such as saliva secretion chewing, greatly reduce residence therapeutic drugs in area lesion. In addition, complex diverse mechanisms make effectively treating periodontitis difficult. Therefore, designing advanced local drug delivery systems rational strategies are basis for successful treatment. Hydrogels have attracted considerable interest field treatment due to their biocompatibility, biodegradability convenient administration pocket. recent years, focus hydrogel research has shifted smart stimuli-responsive hydrogels, which can undergo flexible sol-gel transitions situ control release response stimulation temperature, light, pH, ROS, glucose, or enzymes. this review, we systematically introduce development design emerging hydrogels We also discuss state-of-the-art based on pathogenesis periodontitis. Additionally, challenges future directions discussed from perspective developing efficient potential clinical applications.

Язык: Английский

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Genetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Март 30, 2023

Abstract Biofilm-related diseases are a group of that tolerate antimicrobial chemotherapies and therefore refractory to treatment. Periodontitis, non-device chronic biofilm disease induced by dental plaque, can serve as an excellent in vivo model study the important effects host factors on microenvironment. Macrophage activity is one key modulate progression inflammation-driven destruction periodontitis; it immunomodulatory factor. In this study, reduction microRNA-126 (miR-126) with recruitment macrophages periodontitis was confirmed clinical samples, strategy for targeted delivery miR-126 explored. Exosomes overexpressing C-X-C motif chemokine receptor 4 (CXCR4) loaded (CXCR4-miR126-Exo) successfully constructed, which reduced off-target regulated toward anti-inflammatory phenotype. local injection CXCR4-miR126-Exo into sites rats effectively bone resorption osteoclastogenesis inhibited periodontitis. These results provide new insights designing novel factor systems treat other biofilm-related diseases.

Язык: Английский

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