Biomolecules,
Год журнала:
2024,
Номер
14(2), С. 187 - 187
Опубликована: Фев. 4, 2024
LILRB4,
a
myeloid
inhibitory
receptor
belonging
to
the
family
of
leukocyte
immunoglobulin-like
receptors
(LILRs/LIRs),
plays
pivotal
role
in
regulation
immune
tolerance.
LILRB4
primarily
mediates
suppressive
responses
by
transmitting
signals
through
immunoreceptor
tyrosine-based
motifs
(ITIMs).
This
checkpoint
molecule
has
gained
considerable
attention
due
its
potent
regulatory
functions.
Its
ability
induce
effector
T
cell
dysfunction
and
promote
suppressor
differentiation
been
demonstrated,
indicating
therapeutic
potential
for
modulating
excessive
responses,
particularly
autoimmune
diseases
or
induction
transplant
Additionally,
intervening
with
molecules,
system
responsiveness
can
be
adjusted,
representing
significant
value
areas
such
as
cancer
treatment.
Thus,
emerged
key
player
addressing
diseases,
tolerance
induction,
other
medical
issues.
In
this
review,
we
provide
comprehensive
overview
encompassing
structure,
expression,
ligand
molecules
well
receptor.
By
exploring
involvement
various
significance
disease
progression
is
emphasized.
Furthermore,
propose
that
manipulation
represents
promising
immunotherapeutic
strategy
highlight
prevention,
treatment
diagnosis.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Июнь 19, 2023
T
cells
are
crucial
for
immune
functions
to
maintain
health
and
prevent
disease.
cell
development
occurs
in
a
stepwise
process
the
thymus
mainly
generates
CD4
Molecules,
Год журнала:
2022,
Номер
27(15), С. 4964 - 4964
Опубликована: Авг. 4, 2022
Since
the
early
1980s,
phosphodiesterase
4
(PDE4)
has
been
an
attractive
target
for
treatment
of
inflammation-based
diseases.
Several
scientific
advancements,
by
both
academia
and
pharmaceutical
companies,
have
enabled
identification
many
synthetic
ligands
this
target,
along
with
acquisition
precise
information
on
biological
requirements
linked
therapeutic
opportunities.
The
transition
from
pre-clinical
to
clinical
phase
was
not
easy
majority
these
compounds,
mainly
due
their
significant
side
effects,
it
took
almost
thirty
years
a
PDE4
inhibitor
become
drug
i.e.,
Roflumilast,
used
in
clinics
chronic
obstructive
pulmonary
disease.
then,
three
additional
compounds
reached
market
few
later:
Crisaborole
atopic
dermatitis,
Apremilast
psoriatic
arthritis
Ibudilast
Krabbe
aim
review
is
provide
overview
that
trials
last
ten
years,
focus
those
most
recently
developed
respiratory,
skin
neurological
disorders.
Molecular Biomedicine,
Год журнала:
2023,
Номер
4(1)
Опубликована: Окт. 16, 2023
Abstract
Ferroptosis,
a
regulated
form
of
cellular
death
characterized
by
the
iron-mediated
accumulation
lipid
peroxides,
provides
novel
avenue
for
delving
into
intersection
metabolism,
oxidative
stress,
and
disease
pathology.
We
have
witnessed
mounting
fascination
with
ferroptosis,
attributed
to
its
pivotal
roles
across
diverse
physiological
pathological
conditions
including
developmental
processes,
metabolic
dynamics,
oncogenic
pathways,
neurodegenerative
cascades,
traumatic
tissue
injuries.
By
unraveling
intricate
underpinnings
molecular
machinery,
contributors,
signaling
conduits,
regulatory
networks
governing
researchers
aim
bridge
gap
between
intricacies
this
unique
mode
multifaceted
implications
health
disease.
In
light
rapidly
advancing
landscape
ferroptosis
research,
we
present
comprehensive
review
aiming
at
extensive
in
origins
progress
human
diseases.
This
concludes
careful
analysis
potential
treatment
approaches
carefully
designed
either
inhibit
or
promote
ferroptosis.
Additionally,
succinctly
summarized
therapeutic
targets
compounds
that
hold
promise
targeting
within
various
facet
underscores
burgeoning
possibilities
manipulating
as
strategy.
summary,
enriched
insights
both
investigators
practitioners,
while
fostering
an
elevated
comprehension
latent
translational
utilities.
revealing
basic
processes
investigating
possibilities,
crucial
resource
scientists
medical
aiding
deep
understanding
effects
situations.
Multiple
sclerosis
(MS)
is
an
immune-inflammatory
disease
that
attacks
and
damages
myelinated
axons
in
the
central
nervous
system
(CNS)
causes
nontraumatic
neurological
impairment
young
people.
Historically,
Lidwina
of
Schiedam
documented
first
MS
case.
After
that,
Augustus
d'Este
wrote
for
years
about
how
his
symptoms
worsened.
Age,
sex,
genetics,
environment,
smoking,
injuries,
infections,
including
herpes
simplex
rabies,
are
risk
factors
MS.
According
to
epidemiology,
average
age
onset
between
20
40
years.
more
prevalent
women
common
Europe
America.
As
diagnostic
methods
criteria
change,
people
with
may
be
discovered
at
earlier
stages
disease.
therapy
has
advanced
dramatically
due
breakthroughs
our
knowledge
disease's
etiology
progression.
Therefore,
efficacy
treatment
medications
increased
exponentially.
Management
goals
include
reducing
lesion
activity
avoiding
secondary
Current
approaches
focus
on
managing
acute
episodes,
relieving
symptoms,
biological
activity.
Disease-modifying
drugs
such
as
fingolimod,
interferon-beta,
natalizumab,
dimethyl
fumarate
most
widely
used
treatments
For
proof
safety
these
medications,
investigations
real
world
necessary.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 29, 2024
Background
There
is
increasing
evidence
that
the
types
of
immune
cells
are
associated
with
various
neurodegenerative
diseases.
However,
it
currently
unclear
whether
these
associations
reflect
causal
relationships.
Objective
To
elucidate
relationship
between
and
diseases,
we
conducted
a
two-sample
Mendelian
randomization
(MR)
analysis.
Materials
methods
The
exposure
outcome
GWAS
data
used
in
this
study
were
obtained
from
an
open-access
database
(
https://gwas.mrcieu.ac.uk/
),
employed
MR
analysis
to
assess
731
cell
features
four
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
amyotrophic
lateral
sclerosis
(ALS)
multiple
(MS).
All
was
Multiple
minimize
bias
obtain
reliable
estimates
variables
interest
outcomes.
Instrumental
variable
selection
criteria
restricted
ensure
accuracy
effectiveness
species
risk
Results
identified
potential
relationships
different
Specifically,
found
8
have
AD,
1
type
has
PD,
6
ALS,
MS.
Conclusion
Our
study,
through
genetic
means,
demonstrates
close
specific
ALS
MS,
providing
useful
guidance
for
future
clinical
researches.
Overnutrition
is
a
risk
factor
for
various
human
diseases,
including
neurodegenerative
metabolic
disorders,
and
cancers.
Therefore,
targeting
overnutrition
represents
simple
but
attractive
strategy
the
treatment
of
these
increasing
public
health
threats.
Fasting
as
dietary
intervention
combating
has
been
extensively
studied.
practiced
millennia,
only
recently
have
its
roles
in
molecular
clock,
gut
microbiome,
tissue
homeostasis
function
emerged.
can
slow
aging
most
species
protect
against
These
centuried
unfading
adventures
explorations
suggest
that
fasting
potential
to
delay
help
prevent
treat
diseases
while
minimizing
side
effects
caused
by
chronic
interventions.
In
this
review,
recent
animal
studies
concerning
role
underlying
mechanism
physiology
pathology
are
summarized,
therapeutic
highlighted,
combination
pharmacological
discussed
new
regimen
diseases.
