Advances in Redox Research, Год журнала: 2025, Номер unknown, С. 100126 - 100126
Опубликована: Март 1, 2025
Язык: Английский
Redox Report, Год журнала: 2022, Номер 27(1), С. 92 - 99
Опубликована: Апрель 17, 2022
Background: The cardiovascular crisis is advancing rapidly throughout the world. A large number of studies have shown that plant polyphenols affect major mechanisms involved in events through their action on antioxidant system, signaling, and transcription pathways. D-limonene, a monocyclic monoterpene obtained from citrus fruits, reported to possess many pharmacological activities.Methods: experiment was designed determine protective effect D-limonene against cardiac injury induced by CCl4 Wistar rats. Rats were treated with two doses CCl4. Serum toxicity markers, biomarker enzymes, inflammatory mediators, anti-oxidant armory, lipid peroxidation, profile, histology done.Results: intoxication resulted substantial rise FFA, TC, TG, PL, LDL, VLDL, reduction HDL, restoring these changes administration at dosage 200 mg/kg. also oxidation decreased activity. At same time, mg/kg body weight inhibited LPO restored vivo components normal. significant increase markers like IL-6, TNF-α, high sensitivity Corticotropin Releasing Factor (Hs-CRF), biomarkers alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), MB (CKMB), Troponin I & troponin-t activities. reversed all Histology further confirmed our results.Conclusion: These findings indicate can ameliorate dosage. Henceforth, D-Limonene intervenes mediating various signaling
Язык: Английский
Процитировано
25
Cardiovascular Diabetology, Год журнала: 2023, Номер 22(1)
Опубликована: Март 24, 2023
Abstract Background Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. Objective Main objectives were (1) study whether alcohol was associated with MVD assessed in the brain, retina, skin, blood; (2) investigate associations differed by history cardiovascular or sex. Design We used cross-sectional data from The Maastricht Study (N = 3,120 participants, 50.9% men, mean age 60 years, 27.5% type 2 diabetes [the latter oversampled design]). regression analyses association between total (per unit categories, i.e. none, light, moderate, high) MVD, where all measures combined into composite score (expressed SD). adjusted for potential confounders; tested interaction sex, Additionally we glucose metabolism status. Results non-linear, J-shaped. Moderate versus light significantly less after full adjustment (beta [95% confidence interval], -0.10 [-0.19; -0.01]). shape curve sex (P 0.03), < 0.001), status 0.02). Conclusions present cross-sectional, population-based found evidence that have effect on Hence, although increasing cannot recommended policy, this suggests prevention possible through dietary interventions.
Язык: Английский
Процитировано
15
Phytomedicine, Год журнала: 2023, Номер 115, С. 154808 - 154808
Опубликована: Апрель 6, 2023
Erchen decoction, a traditional Chinese medicine formula, can reduce the level of oxidative stress for treatment dyslipidemia phlegm-dampness retention syndrome (DPDRS); however, studies have not elucidated mechanism underlying its metabolic action. Here, liquid chromatography-mass spectrometry (LC-MS)-based metabolomic techniques were utilized to characterize in vivo effects decoction achieving reduction levels and understand potential mechanisms action.We constructed DPDRS animal model using multifactorial composite modeling approach, was administered by gavage. We employed LC-MS-based combination with serum-associated factors, gene transcription, methylation detection, hematoxylin eosin staining.In this study, had satisfactory quality. reduced low-density lipoprotein cholesterol, t total cholesterol riglyceride; it improved endothelial structure, increased serum β-nicotinamide adenine dinucleotide phosphate glutathione concentrations, aortic phosphoserine aminotransferase phosphatase expression levels, decreased phosphoglycerate dehydrogenase level. A 64 differential metabolites obtained LC-MS assay, 34 pathways after enrichment.Erchen mice reversed lipid indexes, vascular anti-oxidative factor concentration thereby reducing protecting endothelium. Tricarboxylic acid cycle glutamine, serine, tryptophan, pyrimidine, pyruvate most relevant involved during treatment; especially, mitochondrial redox homeostasis maintenance cells may be crucial. In work, therapeutic demonstrated; in-depth is worth further exploration.
Язык: Английский
Процитировано
12
Environmental Science & Technology, Год журнала: 2024, Номер 58(18), С. 7719 - 7730
Опубликована: Апрель 23, 2024
The relationship between phthalates, a group of chemical pollutants classified as endocrine disruptors, and oxidative stress is not fully understood. aim the present hospital-based study was to explore associations circulating levels 10 phthalate metabolites 8 biomarkers in adipose tissue. population (n = 143) recruited two hospitals province Granada (Spain). Phthalate metabolite concentrations were analyzed by isotope diluted online-TurboFlow-LC–MS/MS serum samples, while markers measured commercially available kits tissue collected during routine surgery. Statistical analyses performed MM estimators' robust linear regression weighted quantile sum regression. Mainly, positive observed monomethyl (MMP), monoiso-butyl (MiBP), mono-n-butyl (MnBP) (all low molecular weight phthalates) with glutathione peroxidase (GPx) thiobarbituric acid reactive substances (TBARS), an inverse association found monoiso-nonyl (MiNP) (high phthalate) same biomarkers. WQS showed significant effects mixture on GSH (β −30.089; p-value 0.025) GSSG −19.591; 0.030). Despite limitations inherent cross-sectional design, our novel underlines potential influence exposure redox homeostasis, which warrants confirmation further research.
Язык: Английский
Процитировано
4
Journal of Functional Foods, Год журнала: 2024, Номер 119, С. 106292 - 106292
Опубликована: Июнь 14, 2024
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11457 - 11457
Опубликована: Окт. 25, 2024
Reactive oxygen species (ROS) contribute to endothelial dysfunction, platelet activation, and coagulation abnormalities, promoting thrombus formation. Given the growing interest in non-pharmacological approaches modulate oxidative stress, we examine potential of various dietary interventions antioxidant supplementation reducing damage preventing thrombotic events. Key patterns, such as Mediterranean, Dietary Approaches Stop Hypertension (DASH), ketogenic diets, well antioxidant-rich supplements like curcumin, selenium, polyphenols, demonstrate promising effects improving stress markers, lipid profiles, inflammatory responses. This review highlights recent advances field, drawing from vitro, ex vivo, clinical studies, underscores importance integrating strategies into preventive therapeutic for managing thrombosis cardiovascular health. Further research is needed better understand long-term personalize these optimizing patient outcomes.
Язык: Английский
Процитировано
4
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 323 - 334
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Life, Год журнала: 2025, Номер 15(1), С. 87 - 87
Опубликована: Янв. 13, 2025
Background: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among older adults. Lifestyle modifications, including diet, physical activity, smoking cessation, are key to reducing cardiovascular risk. This study examines the combined effects these behaviors on outcomes their mediating mechanisms. Methods: A cross-sectional was conducted adults (aged ≥ 60 years) in Riyadh, Saudi Arabia. Data dietary quality, status were collected using validated questionnaires. outcomes, low-density lipoprotein cholesterol (LDL), systolic blood pressure (SBP), body mass index (BMI), measured. composite risk score computed. Path analysis employed assess direct indirect lifestyle factors outcomes. Results: Participants adhering healthy engaging regular avoiding had significantly lower scores. Non-smoking showed strongest effect (β = −0.20, p 0.006), while quality activity exhibited significant mediated by LDL, SBP, BMI. Combined adherence multiple resulted greatest reductions The path highlighted as critical mediators health improvements. Conclusions: modifications reduce adults, with cumulative benefits observed for behaviors. These findings emphasize importance comprehensive interventions targeting cessation promote aging populations.
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Erectile dysfunction (ED) is a common condition in men, driven by complex interplay of organic, relational, and psychological factors, necessitating an integrated treatment approach. Psychological such as anxiety, depression, stress, are significant contributors to erectile problems. can have severe consequences, including feelings emasculation, humiliation, reduced self-confidence, isolation, loneliness, decline overall well-being. A national advisory board comprising 12 experts from India, 9 urologists 3 psychiatrists, convened discuss multidisciplinary approach the ED. Using modified Delphi method literature review, 34 panels developed evidence-based insights. Experts highlighted importance thorough assessments sexual patients. Given frequent comorbidity mental health issues with ED, physicians should proactively explore patients' health. Creating secure welcoming environment crucial for these assessments. Physicians gather detailed information on symptoms, stressors, relationship dynamics, cognitive style, distractions. diagnostic recommended integrating pharmacological interventions (e.g., phosphodiesterase-5 inhibitors) psychometric therapy, tailored age, existing comorbidities, underlying causes balanced, interdisciplinary incorporating psychosexual lifestyle modifications, advanced therapies holistic management Key consensus recommendations also emphasized fostering open communication between patients healthcare providers, routine screenings early referrals specialists when necessary. Clinicians actively involve professionals ED prioritize individualized strategies each patient's needs. This multifactorial requires coordinated efforts address both organic psychogenic causes, restore quality life, promote communication. By engaging patients, addressing their concerns, facilitating needed, clinicians significantly improve outcomes
Язык: Английский
Процитировано
0
BMC Public Health, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 12, 2025
Imbalanced dietary patterns, sedentary behavior, and other unhealthy lifestyle behaviors are among the potentially modifiable risk factors most consistently linked to all-cause cardiovascular disease (CVD) mortality. This study aimed investigate joint association of antioxidant intakes from diet supplements behavior with CVD retrospective cohort included 16,019 adults National Health Nutrition Examination Survey (NHANES) 2007–2014. All-cause mortality was ascertained by linkage Death Index records through 31 December 2019. Participants were divided into four patterns based on their intake six antioxidants self-reported behavior: low-antioxidant prolonged nonprolonged high-antioxidant behavior. Multivariable Cox proportional hazards models utilized evaluate associations regards Over an average follow-up 8.5 years, a total 1,894 overall deaths 482 reported. Compared group, participants in group had significantly lower (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.50–0.72) (0.51; 0.34–0.77) Similarly, individuals following engaging also reduced (0.63; 0.52–0.75) (0.54; 0.38–0.76) On hand, there no significant reduction (0.83; 0.68–1.03), as well (0.87; 0.62–1.21). Subgroup sensitivity analyses yielded results that consistent analysis. both lowest Additionally, can help counteract harms diet, whereas fails offset deleterious effect
Язык: Английский
Процитировано
0