The Involvement of Oxidative Stress in Psoriasis: A Systematic Review

Antioxidants, Год журнала: 2022, Номер 11(2), С. 282 - 282

Опубликована: Янв. 29, 2022

Psoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by the appearance of erythematous plaques, covered white scales, occasionally pruritogenic, and distributed mainly on extensor areas. Oxidative stress defined as an imbalance or transient chronic increase in levels free oxygen/nitrogen radicals, either result exaggerated elevation their production decrease ability to be eliminated antioxidant systems. Although pathogenesis psoriasis remains far from elucidated, there are studies that delineate involvement oxidative this skin disorder. Thus, systematic search was computed PubMed/Medline, Web Science SCOPUS and, total, 1293 potentially eligible articles exploring research question were detected. Following removal duplicates exclusion irrelevant manuscripts based screening titles abstracts (n = 995), 298 original selected for full-text review. Finally, after we applied inclusion criteria, 79 included Overall, data analyzed review point out markers elevated share association with duration severity disease. The concentrations these biomarkers impacted anti-psoriasis therapy. In addition, crosstalk between influenced several polymorphisms arise genes encoding enzymes related redox balance. undisputable, future needed explore utility assessing circulating serum, plasma, urinary and/or studying regulating balance, well how can findings translated into management psoriasis, understanding its evolution.

Язык: Английский

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Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(17), С. 6206 - 6206

Опубликована: Авг. 27, 2020

This review discusses how oxidative stress (OS), an imbalance between oxidants and antioxidants in favor of the oxidants, increased production reactive oxygen species (ROS)/reactive nitrogen (RNS), decreased concentration/activity affect pathogenesis or cause enhancement psoriasis (Ps). Here, we also consider ROS/RNS-induced modulates activity transcriptional factors regulates numerous protein kinase cascades that participate regulation crosstalk autophagy, apoptosis, regeneration. Answers to these questions will likely uncover novel strategies for treatment Ps. Action field avoid destructive effects ROS/RNS-mediated OS resulting cellular dysfunction cell death. The combination fragmentary information on role can provide evidence extend full picture

Язык: Английский

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Total Oxidant and Antioxidant Capacity of Gingival Crevicular Fluid and Saliva in Patients with Periodontitis: Review and Clinical Study

Antioxidants, Год журнала: 2020, Номер 9(5), С. 450 - 450

Опубликована: Май 23, 2020

Periodontitis is inextricably linked to oxidative-reductive (redox) imbalance. However, little still known about the resultant ability scavenge oxygen free radicals in saliva and gingival crevicular fluid patients with periodontitis. The multitude of enzymatic non-enzymatic antioxidants their synergistic effects cause an interest evaluation total antioxidative capacity. Thus, our study aimed evaluate oxidative activity periodontitis, as well relate these biomarkers clinical indices periodontopathy. Additionally, by calculating stress index (OSI), intensity redox disturbances was also evaluated. Fifty-eight periodontitis were included divided into two subgroups depending on severity disease. In non-stimulated/stimulated a group, we found significantly higher OSI oxidant status (TOS) lower antioxidant capacity (TAC). reduce iron ions (FRAP) only stimulated non-stimulated examined parameters correlated periodontium’s condition, which indicates exacerbation inflammatory process. TAC, TOS, OSI, FRAP did not differentiate individual stages

Язык: Английский

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Psoriasis between Autoimmunity and Oxidative Stress: Changes Induced by Different Therapeutic Approaches

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 17

Опубликована: Март 12, 2022

Psoriasis is defined as chronic, immune-mediated disease. Regardless of the development new therapeutic approaches, precise etiology psoriasis remains unknown and speculative. The aim this review was to systematize results previous research on role oxidative stress aberrant immune response in pathogenesis psoriasis, well impact certain modalities status patients with psoriasis. Complex pathways both innate adaptive systems appear be major pathomechanisms Oxidative represents another important contributor pathophysiology disease, redox imbalance has been reported skin cells and, systemically, plasma blood cells, more recently, also saliva. Current model begins activation system susceptible person by some environmental factor loss tolerance autoantigens. Increased production IL-17 appears most prominent pathogenesis, while IL-23 recognized master regulator having a specific cross bridging acquired immunity. Other proinflammatory cytokines, including IFN-γ, TNF-α, IL-1β, IL-6, IL-22, IL-26, IL-29, or IL-36, have play roles can promote inflammation through several signaling pathways. noticeable powerful antioxidative effects exert various biologics compared convenient modalities, such methotrexate phototherapy. complex interaction redox, immune, inflammatory should focused further researches tackling supplementation could solution refractory cases

Язык: Английский

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Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 154, С. 113601 - 113601

Опубликована: Авг. 29, 2022

Skin, the largest vital organ of human body, provides first line defense against biological, non-biological and xenobiotics exposure. Over years, due to increased anthropogenic activities including industrialization pollution, a steep increase in cutaneous pathological conditions such as malignancies, dermatitis, psoriasis has been detected. Indeed, complex nature inflammatory diseases, further investigations are required produce better outcome patient care. However, research obtained over last few decades revolutionized understanding disease pathogenesis therapeutic developments. In this line, increasing data from pre-clinical clinical studies implicates crucial role oxidative stress complications atopic dermatitis psoriasis. Taking into consideration current challenge, review aims highlight novel updates exploring reactive oxygen species (ROS) induced mechanistic signaling mechanisms conjunction with pathways converging towards Additionally, an exploration importance natural products for management diseases included. Overall, highlights targeting pathogenesis, symptoms, skin.

Язык: Английский

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Pro-Oxidant Enzymes, Redox Balance and Oxidative Damage to Proteins, Lipids and DNA in Colorectal Cancer Tissue. Is Oxidative Stress Dependent on Tumour Budding and Inflammatory Infiltration?

Cancers, Год журнала: 2020, Номер 12(6), С. 1636 - 1636

Опубликована: Июнь 20, 2020

This study is the first to assess redox homeostasis in patients with colorectal cancer (CRC) respect histopathological parameters associated tumour microenvironment such as budding and inflammatory infiltration. Pro-oxidant enzymes (NADPH oxidase (NOX), xanthine (XO)), antioxidant barrier (Cu,Zn-superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reductase (GR), reduced (GSH)), status (total (TAC)/oxidant (TOS)) oxidative damage products (advanced glycation end (AGE), advanced oxidation protein (AOPP), malondialdehyde (MDA) 8-hydroxydeoxyguanosine (8-OHdG)) were determined both normal cancerous tissue of 29 CRC patients. The activity NOX (p < 0.01) XO = 0.01), well SOD 0.0001), CAT 0.0001) TAC level significantly higher than colon mucosa. Oxidative (AGE—p 0.01, AOPP—p 0.001, MDA—p 8-OHdG—p also tissue. Furthermore, we observed that 0.05) depends on intensity stress index (OSI) MDA values (TB) > 5 versus cases TB 5. However, OSI did not differ between Our results confirm enzymatic/non-enzymatic imbalance increased proteins, lipids DNA. determination these biomarkers could be useful for evaluation progression.

Язык: Английский

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Very low-calorie ketogenic diet (VLCKD) in patients with psoriasis and obesity: an update for dermatologists and nutritionists

Critical Reviews in Food Science and Nutrition, Год журнала: 2020, Номер 62(2), С. 398 - 414

Опубликована: Сен. 24, 2020

Psoriasis is a chronic skin immune-mediated disease with systemic pro-inflammatory activation; both genetic and lifestyles factors contribute to its pathogenesis severity. In this context, nutrition plays significant role, per se, in psoriasis' pathogenesis. Obesity another important risk factor for psoriasis, weight reduction may improve clinical The excess body weight, particularly visceral fat mass, can affect drug's pharmacokinetics pharmacodynamics. Therefore, psoriasis obesity share certain degree of synergy, the inflammatory state represents basis vicious cycle. Evidence reported that has different impact on severity though some specific diets have been more investigated studies compared others. Diets anti-inflammatory properties seem higher effect improving psoriasis. Of interest, very-low-calorie ketogenic diet (VLCKD), through production ketone bodies, associated state. VLCKD leading loss inflammation decrease exacerbation manifestations or even it block trigger psoriatic disease. This dietary pattern could represent potential first-line treatment patients obesity. review aims summarize current evidence regarding reference antioxidant effects pattern.

Язык: Английский

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Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Journal of Clinical Medicine, Год журнала: 2020, Номер 9(2), С. 497 - 497

Опубликована: Фев. 12, 2020

Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, Parkinson’s and Huntington’s are disorders, which cause irreversible progressive deterioration of the central nervous system. The pathophysiology NDDs is still not fully explained; nevertheless, oxidative stress considered a critical mediator cerebral degeneration, brain inflammation, well neuronal apoptosis. Therefore, it surprising that redox biomarkers increasingly used in diagnosis neurodegenerative diseases. As saliva very easy to obtain bioliquid, seems promising use this biomaterial NDDs. Saliva collection easy, cheap, stress-free, non-infectious, does require help specialised medical personnel. Additionally, concentrations many salivary correlate with their content blood serum degree disease progression, makes them non-invasive indicators This paper reviews latest knowledge concerning prognosis selected

Язык: Английский

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Salivary Oxidative Stress Increases with the Progression of Chronic Heart Failure

Journal of Clinical Medicine, Год журнала: 2020, Номер 9(3), С. 769 - 769

Опубликована: Март 12, 2020

The aim of the study was to evaluate rate reactive oxygen species (ROS) production, antioxidant barrier, and oxidative damage in non-stimulated (NWS) stimulated (SWS) saliva as well plasma/erythrocytes 50 patients with chronic heart failure (HF) divided into two subgroups: NYHA II (33 patients) III (17 patients). activity superoxide dismutase catalase statistically increased NWS HF compared healthy controls. free radical formation, total oxidant status, level uric acid, advanced glycation end products (AGE), oxidation protein malondialdehyde significantly elevated NWS, SWS, plasma We were first demonstrate that progression HF, disturbances enzymatic non-enzymatic defense, proteins lipids occur at both central (plasma/erythrocytes) local (saliva) levels. In group, we also observed a decrease secretion, salivary amylase age- gender-matched control which indicates secretory dysfunction glands HF. Salivary AGE may be potential biomarker differential diagnosis

Язык: Английский

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A Case-Control Study of Salivary Redox Homeostasis in Hypertensive Children. Can Salivary Uric Acid be a Marker of Hypertension?

Journal of Clinical Medicine, Год журнала: 2020, Номер 9(3), С. 837 - 837

Опубликована: Март 19, 2020

Oxidative stress plays a critical role in the pathogenesis of hypertension; however, there are no data on salivary redox homeostasis and gland function children with hypertension. A total 53 hypertension age- sex-matched controls were classified for study. The antioxidant barrier oxidative/nitrosative evaluated non-stimulated (NWS) stimulated (SWS) whole saliva, plasma, erythrocytes, Student’s t-test Mann–Whitney U-test used statistical analysis. We demonstrated that activities superoxide dismutase, catalase, peroxidase significantly higher NWS, SWS, erythrocytes hypertension, similar to oxidative damage proteins (advanced glycation end products) lipids (malondialdehyde) as well nitrosative markers (peroxynitrite nitrotyrosine). level uric acid (UA) was plasma UA concentration SWS correlated positively systolic diastolic blood pressure content plasma. This parameter differentiates from healthy (AUC = 0.98) high degree sensitivity (94%) specificity (94%). Stimulated flow lower group, protein amylase activity. In summary, childhood is associated hyposalivation disturbances defense enhanced both plasma/erythrocytes saliva. Salivary may be potential biomarker children.

Язык: Английский

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