Journal of Taibah University Medical Sciences, Год журнала: 2024, Номер 19(6), С. 1098 - 1099
Опубликована: Ноя. 29, 2024
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(23), С. 4164 - 4164
Опубликована: Ноя. 30, 2024
The dietary index for gut microbiota (DI-GM) is a newly proposed metric assessing diet quality, and its relationship with biological age unclear. We hypothesize that consuming foods conducive to healthy environment may decelerate aging.
Язык: Английский
Процитировано
5
Molecular Biomedicine, Год журнала: 2024, Номер 5(1)
Опубликована: Авг. 19, 2024
Abstract Transcription, RNA splicing, translation, and post-translational protein modification are fundamental processes of gene expression. Epigenetic modifications, such as DNA methylation, play a crucial role in regulating The methyltransferase-like (METTL) family, constituent the 7-β-strand (7BS) methyltransferase subfamily, is broadly distributed across cell nucleus, cytoplasm, mitochondria. Members METTL through their S-adenosyl methionine (SAM) binding domain, can transfer methyl groups to DNA, RNA, or proteins, thereby impacting replication, transcription, mRNA participate maintenance normal function promote disease development. This review primarily examines involvement family differentiation, mitochondrial function, its association with tumor formation, nervous system, cardiovascular diseases. Notably, intricately linked cellular particularly regulation translation factors. represent important molecules development associated patient immunity tolerance radiotherapy chemotherapy. Moreover, future research directions could include drugs antibodies targeting structural domains, utilizing nanomaterials carry miRNA corresponding mRNA. Additionally, precise mechanisms underlying interactions between factors remain be clarified.
Язык: Английский
Процитировано
4
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Сен. 20, 2024
Oral cavity squamous cell carcinoma (OCSCC) predominantly affects the tongue and floor of mouth, primarily in patients over 50 years age. Incidence mortality rates vary significantly worldwide, influenced by geographic areas demographic characteristics. Epidemiological studies revealed an increase incidence OCSCC among young adults (YA) <44 old. This narrative review, provides updated information on incidence, risk factors, prognosis YA-OCSCC using data published from 2018 to 2023 different locations. The indicate that Asia is approximately twice US strongly linked factors such as betel quid chewing, tobacco use, high alcohol consumption. for YA-OCSCC, compared older patients, shows similar or better overall survival, even cases with relapses, but worse 5-year disease-free despite receiving treatments. Consequently, a concerted effort crucial raise awareness about cessation areca nut control, promotion healthy lifestyle behaviors. Recent molecular suggests potential profile characterized epidermal growth factor receptor overexpression, low tumor mutation burden attenuated immune response. Upon confirmation larger cohorts geographical areas, validated markers could aid selecting tailored
Язык: Английский
Процитировано
4
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Abstract Environmental exposure such as cigarette smoke induces epigenetic changes that can induce degenerative heterogeneity and accelerate aging. In early age-related macular degeneration (AMD), the leading worldwide cause of blindness among elderly, retinal pigment epithelial (RPE) cell is a key change. Since smoking strongest environmental risk factor for AMD, we hypothesized RPE through are distinct from aging, with becomes vulnerable to insult. We administered condensate (CSC) intravitreally young aged mice performed snRNA-seq snATAC-seq on RPE/choroid. This analysis identified separate clusters corresponding healthy abnormal, dedifferentiated in both vehicle-treated CSC-treated mice. The were characterized by global decrease chromatin accessibility decreased expression genes functional categories linked hallmarks Notably, young, also exhibited compensatory upregulation aging-related genes, specifically those related mitochondrial function proteostasis. contrast, did not express these changes, survive CSC treatment, experimentally verified TUNEL labeling. These relevant AMD because scRNA-seq, similar donor who smoked another but nonsmoker. Degenerative cellular include an abnormal cluster jeopardizes survival may represent additional hallmark ocular
Язык: Английский
Процитировано
0
British Journal of Hospital Medicine, Год журнала: 2025, Номер unknown, С. 1 - 6
Опубликована: Март 5, 2025
Tobacco is one of the great scourges modern health, and e-cigarettes are suggested to be a means smoking cessation harm reduction. This editorial shows that, far from being source reduction, they aggressively marketed children young people. The acute effects greater than those tobacco, thus we cannot complacent about long-term effects. There accumulating data that immunosuppressive, pro-inflammatory lead epigenetic pre-cancerous. an urgent need for legislation actually enforced protect next-generation nicotine addicts.
Язык: Английский
Процитировано
0
Cellular & Molecular Biology Letters, Год журнала: 2025, Номер 30(1)
Опубликована: Апрель 10, 2025
Язык: Английский
Процитировано
0
European Heart Journal Supplements, Год журнала: 2025, Номер 27(Supplement_3), С. iii25 - iii27
Опубликована: Март 1, 2025
Abstract E-cigarettes and heated tobacco products have been marketed as safer alternatives to traditional cigarettes, leading consumers believe that they will reduce health risks. However, the scientific evidence collected so far calls this hypothesis into question. Their use a means of smoking cessation has not only led unequivocal results on their effectiveness, but some studies even suggest could increase risk initiation or relapse nicotine addiction. Furthermore, research indicates both e-cigs contain toxic substances can consequently cause risks, such lung, cardiovascular, oncological diseases. The combination, so-called dual consumption, these with seems further amplify risks cancer other smoking-related It is important underline long-term effects new forms consumption are still being studied. information available suggests harmless at all. lack regulation variety market also make it difficult assess specific associated each device.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8554 - 8554
Опубликована: Авг. 5, 2024
Electronic cigarette (e-cig) use, otherwise known as “vaping”, is widespread among adolescent never-smokers and adult smokers seeking a less-harmful alternative to combustible tobacco products. To date, however, the long-term health consequences of vaping are largely unknown. Many toxicants carcinogens present in e-cig vapor smoke exert their biological effects through epigenetic changes that can cause dysregulation disease-related genes. Long non-coding RNAs (lncRNAs) have emerged prime regulators gene expression disease states. A large body research has shown lncRNAs regulate genes involved pathogenesis smoking-associated diseases; utility for assessing disease-causing potential remains be fully determined. limited but growing number studies mediate cells tissues vapers well treated vitro with aerosol extract. This review article provides an overview evolution technology, trends controversies on safety, efficacy, risks or benefits relative smoking. While highlighting importance cell biology disease, it summarizes current ongoing modulatory regulation users experimental settings. The gaps knowledge identified, priorities future highlighted, empirical data products public underscored.
Язык: Английский
Процитировано
2
PeerJ, Год журнала: 2024, Номер 12, С. e18559 - e18559
Опубликована: Ноя. 22, 2024
Lung cancer (LC) remains one of the most prevalent and lethal malignancies globally, with a 5-year survival rate for advanced cases persistently below 10%. Despite significant advancements in immunotherapy, substantial proportion patients LC fail to respond effectively these treatments, highlighting an urgent need novel immunotherapeutic targets. The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway has gained prominence as potential target improving immunotherapy due its pivotal role enhancing anti-tumor immune responses, augmenting tumor antigen presentation, promoting T cell infiltration. However, emerging evidence also suggests that cGAS-STING may have pro-tumorigenic effects context LC. This review aims provide comprehensive analysis pathway, including biological composition, activation mechanisms, physiological functions, well dual roles current treatment strategies pathway. By addressing aspects, we intend highlight target, while considering challenges future directions clinical application.
Язык: Английский
Процитировано
2
Journal of Dental Sciences, Год журнала: 2024, Номер 19(4), С. 1919 - 1923
Опубликована: Авг. 3, 2024
Many people have associated e-cigarettes with adjectives such as trendy and cool, regarded vaping "a safer alternative to cigarette smoking". Compared the conventional cigarettes, public is less familiar dangers of e-cigarettes. E-cigarettes produce an aerosol by heating e-liquid (usually comprising nicotine, flavorings, propylene glycol, vegetable glycerin, other additives). Harmful substances are generated during vaporization, formaldehyde. Cellular damages DNA hypermethylation also found be vaping. We reviewed clinical neoplastic cases patients history (three oral squamous cell carcinomas, one conjunctival intraepithelial neoplasia, thoracic NUT-midline carcinoma). These tend younger than average cancer patients. Although exact relations between cellular or still need further investigations, we should very careful about using aids for smoking cessation.
Язык: Английский
Процитировано
1